Description

TOPASIGN 50 TABLET is a prescription medication comprising Topiramate 50 mg, an antiepileptic drug (AED) with proven efficacy in managing seizures and preventing migraines. Topiramate belongs to the sulfamate-substituted monosaccharide class and works through multiple mechanisms, including enhancing GABA activity, inhibiting glutamate receptors, and blocking voltage-gated sodium and calcium channels.

This multi-action mechanism makes TOPASIGN suitable for a wide range of seizure disorders, including partial-onset seizures, generalized tonic-clonic seizures, and seizures associated with Lennox-Gastaut syndrome. It is also clinically approved for migraine prophylaxis in adults and adolescents.

Manufactured and supplied by Bluepill Express, a globally recognized third-party pharmaceutical exporter, TOPASIGN 50 TABLET is produced in WHO-GMP certified facilities and is available for international markets, including bulk exports and private labelling.

• Contains Topiramate 50 mg – broad-spectrum antiepileptic

• Effective in controlling a wide range of seizure types

• Used in migraine prevention therapy

• Manufactured under international quality certifications

• Globally exported by Bluepill Express

• Partial-onset seizures in adults and children

• Primary generalized tonic-clonic seizures

• Lennox-Gastaut syndrome (as adjunctive therapy)

• Prophylaxis of migraine headaches

• Enhances the activity of GABA (gamma-aminobutyric acid) – an inhibitory neurotransmitter

• Inhibits AMPA/kainate subtype of glutamate receptors (excitatory neurotransmission)

• Blocks voltage-gated sodium channels, stabilizing neuronal membranes

• Inhibits certain calcium channels, reducing neurotransmitter release

• Dosage depends on the indication and patient profile

• Typically initiated at low doses and titrated gradually to minimize side effects

• Should be taken orally with or without food

• Always follow the dosage as prescribed by a physician

• Not recommended during pregnancy unless clearly needed (risk of birth defects)

• Use caution in patients with renal or hepatic impairment

• May cause drowsiness, dizziness, or cognitive disturbances

• Adequate hydration is advised to prevent kidney stones

• Sudden withdrawal may lead to seizure recurrence

• Fatigue, dizziness, drowsiness

• Loss of appetite, weight loss

• Cognitive issues (memory, attention)

• Nausea, tingling in limbs

• Mood changes or depression (rare)

• Store at room temperature (below 30°C)

• Protect from moisture and direct sunlight

• Keep out of reach of children

• Produced in WHO-GMP, ISO, and other certified facilities

• Complies with global export documentation and regulations

• Available for bulk orders, custom packaging, and third-party branding

• Trusted by healthcare providers and pharmaceutical distributors worldwide

• Backed by Bluepill Express, a leader in global medicine exports