TRIMETHOPRIM

Trimethoprim is a broad-spectrum antibacterial agent primarily used to treat bacterial infections of the urinary tract, respiratory system, and gastrointestinal tract. It acts as a dihydrofolate reductase inhibitor, preventing bacterial DNA synthesis and replication, making it highly effective against both Gram-positive and Gram-negative organisms.

At Bluepill Express, we manufacture and export Trimethoprim Active Pharmaceutical Ingredient (API) with superior purity, consistent assay values, and compliance with international pharmacopeial standards — including IP, BP, USP, and EP. Our manufacturing facilities are WHO-GMP, ISO, and cGMP-certified, ensuring global-standard quality suitable for regulated and semi-regulated markets.

Trimethoprim is often formulated alone or in combination with Sulfamethoxazole (as Co-trimoxazole) for enhanced antibacterial efficacy. The API exhibits excellent stability, uniform particle size distribution, and high solubility for versatile pharmaceutical applications.

Therapeutic Applications:

• Urinary Tract Infections (UTIs)
• Respiratory Tract Infections (RTIs)
• Gastrointestinal Bacterial Infections
• Skin and Soft Tissue Infections
• Prophylaxis and treatment of Pneumocystis jirovecii pneumonia (PCP)

Mechanism of Action:

Trimethoprim selectively inhibits bacterial dihydrofolate reductase (DHFR) — an enzyme crucial for the synthesis of tetrahydrofolic acid, a component required for bacterial DNA and protein synthesis. This inhibition stops bacterial growth, providing bacteriostatic action.

Technical Specifications:

• Chemical Name: 5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-diamine
• Molecular Formula: C₁₄H₁₈N₄O₃
• Molecular Weight: 290.32 g/mol
• CAS Number: 738-70-5
• Appearance: White to off-white crystalline powder
• Assay (on dried basis): NLT 98.0% and NMT 102.0%
• Solubility: Slightly soluble in water; freely soluble in alcohol
• Melting Point: 200°C – 203°C
• Storage Conditions: Store below 30°C, protected from light and moisture

Pharmacological Classification:

• Therapeutic Class: Antibacterial Agent / Dihydrofolate Reductase Inhibitor
• Pharmacopoeial Standards: IP / BP / USP / EP
• Common Formulations: Tablets, Oral Suspensions, Injections, Co-trimoxazole combinations

Manufacturing Excellence – Bluepill Express:

• WHO-GMP, ISO 9001:2015, and cGMP-certified manufacturing
• Analytical testing using HPLC and FTIR for purity assurance
• Low residual solvents and impurity profile
• Stable crystalline form ensuring extended shelf life
• Regulatory-compliant documentation for global registrations

Advantages of Bluepill Express Trimethoprim API:

• High assay purity (≥99%)
• Complies with IP/BP/USP/EP standards
• Low microbial contamination and moisture content
• Suitable for oral and injectable formulations
• Available with DMF, COA, MSDS, and Stability Data

Packaging & Export Details:

• Packaging Sizes: 5 kg, 10 kg, 25 kg HDPE drums with double inner liners
• Labeling: Export-compliant and batch traceable
• Shelf Life: 36 months from date of manufacture
• Export Markets: Africa, Asia, Middle East, Latin America, and Europe
• Documentation Provided:
  • Certificate of Analysis (COA)
  • Material Safety Data Sheet (MSDS)
  • Stability Data
  • Technical Data Sheet (TDS)
  • Drug Master File (DMF) on request