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Propranolol Hydrochloride is a non-selective beta-adrenergic receptor blocking agent (beta-blocker) widely used in the treatment of hypertension, angina pectoris, cardiac arrhythmias, anxiety disorders, and migraine prophylaxis.
At Bluepill Express, we manufacture and export high-purity Propranolol Hydrochloride API that complies with IP, BP, USP, and EP pharmacopeial standards. Our API is known for its excellent stability, purity, and bioavailability, making it suitable for use in a variety of solid oral dosage forms such as tablets and capsules.
Manufactured in WHO-GMP, ISO 9001:2015, and cGMP certified facilities, Bluepill Express ensures every batch undergoes stringent HPLC and spectrophotometric testing, ensuring international quality and consistency.
Therapeutic Uses
- Management of high blood pressure (hypertension)
- Treatment of angina pectoris (chest pain)
- Control of cardiac arrhythmias
- Prevention of myocardial infarction (heart attack)
- Management of essential tremor
- Control of anxiety and panic disorders
- Migraine prophylaxis and relief
Mechanism of Action
Propranolol Hydrochloride works by blocking beta-1 and beta-2 adrenergic receptors in the heart and peripheral tissues. This reduces the effects of adrenaline (epinephrine) and noradrenaline, leading to decreased heart rate, cardiac output, and blood pressure.
Additionally, it suppresses renin release from the kidneys, further supporting blood pressure control. The drug’s central nervous system penetration also contributes to its efficacy in treating anxiety and migraine.
Pharmacological Information
- Chemical Name: 1-(Isopropylamino)-3-(1-naphthyloxy)-2-propanol hydrochloride
- Molecular Formula: C16H21NO2·HCl
- Molecular Weight: 295.8 g/mol
- CAS Number: 318-98-9
- Therapeutic Class: Beta-Adrenergic Blocker
- Pharmacological Class: Non-selective Beta-Blocker
- ATC Code: C07AA05
Physical & Chemical Properties
| Property | Description |
|---|---|
| Appearance | White or almost white crystalline powder |
| Odor | Odorless |
| Taste | Slightly bitter |
| Solubility | Soluble in water, ethanol, and methanol |
| Melting Point | 163°C – 165°C |
| pH (1% solution) | 4.5 – 5.5 |
| Storage | Store below 25°C in a tightly closed container, protected from light and moisture |
Technical Specifications
| Parameter | Specification |
|---|---|
| Description | White crystalline powder |
| Identification | Positive (IR, UV absorption) |
| Assay (on dry basis) | 98.5% – 101.0% |
| Loss on Drying | ≤ 0.5% |
| Residue on Ignition | ≤ 0.1% |
| Heavy Metals | ≤ 10 ppm |
| Specific Rotation | +9.5° to +11.0° |
| Related Substances | ≤ 0.3% (individual impurity) |
| Optical Purity | Meets pharmacopeial standards |
| Bulk Density | 0.35 – 0.50 g/mL |
| Tapped Density | 0.50 – 0.65 g/mL |
Applications
Propranolol Hydrochloride API is used in:
- Antihypertensive formulations
- Cardiac and anti-arrhythmic tablets
- Anxiolytic and anti-tremor medications
- Migraine prophylactic drugs
- Post-myocardial infarction treatment combinations
Advantages of Bluepill Express Propranolol Hydrochloride
- Pharmacopeial-grade purity (IP / BP / USP / EP)
- Excellent solubility and stability profile
- Batch-to-batch consistency verified through analytical QC
- Complies with WHO-GMP and cGMP international manufacturing norms
- Suitable for both immediate and extended-release formulations
- Fully traceable documentation and technical support available
Documentation Provided
- Certificate of Analysis (COA)
- Material Safety Data Sheet (MSDS)
- Technical Data Sheet (TDS)
- Method of Analysis (MOA)
- Stability Data (available on request)
- Regulatory Dossier / DMF (on request)
Packaging & Export Details
- Available Packs: 1 kg | 5 kg | 10 kg | 25 kg HDPE drums with double liners
- Labeling: As per international export norms (includes product name, batch number, Mfg./Exp. date, and storage instructions)
- Shelf Life: 36 months under recommended storage conditions
- Export Destinations: Africa, Asia, Latin America, Europe, and the Middle East
