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Paracetamol Powder (Acetaminophen) is one of the world’s most widely used analgesic (pain reliever) and antipyretic (fever reducer) active pharmaceutical ingredients (API). It is an essential drug in both prescription and over-the-counter (OTC) formulations, used for managing mild to moderate pain and reducing fever in patients of all age groups.
At Bluepill Express, we manufacture and export premium-grade Paracetamol Powder that complies with IP, BP, USP, and EP standards. Our product is widely demanded by formulators, contract manufacturers, and pharmaceutical companies globally for its consistent assay value, excellent flow properties, and low impurities.
Therapeutic Uses
- Relief of fever and pain in colds, flu, and infections
- Treatment of headache, migraine, toothache, backache, and menstrual pain
- Adjunct therapy in post-surgical and musculoskeletal pain
- Commonly used in combination with caffeine, ibuprofen, or codeine for enhanced efficacy
Mechanism of Action
Paracetamol acts primarily on the central nervous system by inhibiting the cyclooxygenase (COX-3) enzyme, which decreases prostaglandin synthesis. This results in:
- Reduction in pain perception at the central level
- Decrease in body temperature through action on the hypothalamic heat-regulating center
Unlike NSAIDs, Paracetamol does not cause gastric irritation or platelet aggregation, making it a safe and preferred antipyretic for sensitive patients.
Pharmacological Information
- Chemical Name: N-(4-hydroxyphenyl)acetamide
- Synonyms: Acetaminophen, p-Hydroxyacetanilide
- Molecular Formula: C8H9NO2
- Molecular Weight: 151.16 g/mol
- CAS Number: 103-90-2
- Therapeutic Class: Analgesic / Antipyretic
- Pharmacopoeial Standards: IP / BP / USP / EP
Physical & Chemical Properties
| Property | Description |
|---|---|
| Appearance | White to almost white crystalline powder |
| Odor | Odorless |
| Taste | Slightly bitter |
| Melting Point | 168°C – 172°C |
| Solubility | Freely soluble in alcohol and acetone; slightly soluble in water |
| pH (1% solution) | 5.5 – 7.5 |
| Bulk Density | 0.35 – 0.55 g/cm³ |
| Tapped Density | 0.50 – 0.70 g/cm³ |
| Storage Conditions | Store below 25°C, away from moisture and direct sunlight |
Technical Specifications
| Parameter | Specification |
|---|---|
| Appearance | White crystalline powder |
| Identification | IR, UV – Complies |
| Assay (Purity) | 99.0% – 101.0% (on dried basis) |
| Loss on Drying | ≤ 0.5% |
| Residue on Ignition | ≤ 0.1% |
| p-Aminophenol (Impurity A) | ≤ 50 ppm |
| 4′-Nitrophenol | ≤ 50 ppm |
| Sulphated Ash | ≤ 0.1% |
| Chloride & Sulphate | Within IP/BP/USP limits |
| Particle Size Distribution | Custom grades – Fine, Semi-Fine, Granular, DC grades |
Applications
- Tablets & Capsules formulations
- Syrups and Suspensions for pediatric use
- Effervescent and dispersible tablets
- Suppositories and topical formulations
- Used in pharma, nutraceutical, and veterinary formulations
Documentation Provided
- Certificate of Analysis (COA)
- Material Safety Data Sheet (MSDS)
- Technical Data Sheet (TDS)
- Stability Data (ICH compliant)
- Regulatory Dossier / DMF (on request)
Packaging & Export Details
| Packaging Type | Net Weight |
|---|---|
| HDPE Drum | 25 kg |
| Fiber Drum | 25 kg |
| LDPE Bag | 1 kg / 5 kg / 10 kg (sample or bulk) |
- Labeling: Product Name, Batch No., MFG & EXP Date, Net Weight, Storage Conditions
- Shelf Life: 5 years (when stored properly)
- Export Regions: Asia, Africa, Middle East, Latin America, CIS, and Europe
