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Paracetamol Granular API, also known as Acetaminophen Granular, is a widely used analgesic (pain reliever) and antipyretic (fever reducer) active pharmaceutical ingredient. It is formulated in granular form to ensure excellent flowability, compressibility, and uniform blending, making it ideal for tablet and capsule formulations in large-scale pharmaceutical manufacturing.
Paracetamol works by inhibiting prostaglandin synthesis in the central nervous system and blocking pain impulses, thereby providing fast and effective relief from headache, fever, toothache, cold, muscular pain, backache, and arthritis-related discomfort. It is one of the safest and most effective over-the-counter (OTC) APIs globally, suitable for adults and children.
At Bluepill Express, Paracetamol Granular API is produced under WHO-GMP, ISO, and cGMP-certified manufacturing standards. The API is characterized by high assay purity, controlled moisture content, and uniform particle size distribution, ensuring superior performance during compression and formulation. It complies fully with USP / BP / IP pharmacopoeial standards, and each batch is validated through advanced analytical methods including HPLC and UV spectrophotometry.
Therapeutic Applications
- Relief from fever (antipyretic action)
- Reduces mild to moderate pain (headache, toothache, joint pain, back pain, etc.)
- Used in formulations for common cold and flu
- Suitable for single-ingredient or combination analgesic formulations
- Preferred choice for paediatric, adult, and geriatric dosage forms
Technical Specifications:
- Chemical Name: Paracetamol (Acetaminophen)
- Molecular Formula: C₈H₉NO₂
- Molecular Weight: 151.16 g/mol
- CAS Number: 103-90-2
- Appearance: White or almost white crystalline granular powder
- Assay (on dried basis): NLT 99.0%
- Loss on Drying: NMT 0.5%
- Solubility: Sparingly soluble in water; soluble in alcohol
- Bulk Density: 0.45–0.55 g/ml (typical range for granular form)
- Storage Conditions: Store below 30°C in a cool, dry place, protected from light and moisture.
Pharmacological Action:
Paracetamol exerts its analgesic and antipyretic effects by inhibiting cyclooxygenase (COX) enzymes, particularly COX-3 in the central nervous system. This inhibition reduces prostaglandin synthesis, leading to decreased pain perception and body temperature regulation. Unlike NSAIDs, Paracetamol has minimal gastrointestinal or antiplatelet side effects, making it safe for long-term use under medical supervision.
Manufacturing & Quality Assurance (by Bluepill Express):
- Manufactured under WHO-GMP, ISO 9001:2015, and cGMP standards
- Complies with USP / BP / IP pharmacopoeial specifications
- Supported with COA, MSDS, and DMF documentation for global export
- High purity and superior compressibility for direct compression use
- Each batch undergoes HPLC, GC, and IR testing for quality verification
- Exported to regulated and semi-regulated markets worldwide
Advantages of Paracetamol Granular Form:
- Improved flow and blending properties
- Ideal for high-speed tablet compression
- Reduced dust formation during manufacturing
- Ensures uniform content distribution in solid dosage forms
- Suitable for film-coated, effervescent, and dispersible tablets
