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Nortriptyline Hydrochloride API is a potent tricyclic antidepressant (TCA) active pharmaceutical ingredient widely used in the formulation of medications designed to treat depression, anxiety disorders, and neuropathic pain. It works primarily by inhibiting the reuptake of norepinephrine and serotonin in the brain, helping to restore the balance of natural neurotransmitters and improve mood, energy levels, and mental well-being.
Nortriptyline Hydrochloride is also utilized in managing chronic pain conditions, migraine prevention, and nocturnal enuresis (bedwetting) in children. It is the active demethylated metabolite of Amitriptyline, offering better tolerability and fewer sedative effects. The API is suitable for use in tablet, capsule, and oral suspension formulations, providing reliable pharmacological activity and consistent therapeutic outcomes.
At Bluepill Express, Nortriptyline Hydrochloride API is produced under WHO-GMP, ISO, and cGMP-certified facilities, ensuring the highest standards of purity, stability, and assay precision. Each batch undergoes rigorous quality control testing and complies with USP / BP / IP pharmacopoeial specifications.
Therapeutic Applications:
- Treatment of major depressive disorders (MDD)
- Management of chronic neuropathic pain
- Used for migraine prophylaxis
- Helps manage generalized anxiety and panic disorders
- Treatment support in nocturnal enuresis (in specific cases under medical supervision)
Technical Specifications:
- Chemical Name: Nortriptyline Hydrochloride
- Molecular Formula: C₁₉H₂₁N·HCl
- Molecular Weight: 299.84 g/mol
- CAS Number: 894-71-3
- Appearance: White to off-white crystalline powder
- Solubility: Freely soluble in water and alcohol
- Assay (on dried basis): NLT 99.0%
- Storage: Store in a cool, dry place below 30°C, protected from light and moisture
Pharmacological Action:
Nortriptyline Hydrochloride works by blocking the reuptake of norepinephrine and serotonin at the presynaptic neuron. This enhances neurotransmission in the central nervous system, alleviating depressive symptoms and improving mood. Its secondary amine structure makes it less sedating and better tolerated than other tricyclic antidepressants like Amitriptyline.
Manufacturing & Quality Assurance (by Bluepill Express):
- Produced in WHO-GMP, ISO 9001:2015, and cGMP certified manufacturing units
- Supported with COA, MSDS, and DMF documentation for global registration
- Complies with USP / BP / IP pharmacopoeial standards
- Batch-to-batch consistency and analytical purity validated by HPLC and IR spectroscopy
- Supplied for global formulations including tablets, capsules, and liquid orals
