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Metoprolol Tartrate is a selective β1-adrenergic receptor blocker (beta-blocker) widely used in the management of hypertension, angina pectoris, and heart failure, as well as for the prevention of myocardial infarction. It reduces heart rate, cardiac output, and blood pressure by selectively inhibiting β1-receptors in cardiac tissue without significant effect on β2-receptors in the lungs.
Bluepill Express offers high-purity Metoprolol Tartrate API, manufactured under WHO-GMP, ISO 9001:2015, and cGMP-certified facilities, ensuring consistent quality, stability, and compliance with pharmacopoeial standards (IP, BP, USP, EP). This API is suitable for tablet and oral solid formulations intended for global markets.
Therapeutic Uses
- Hypertension: Lowers blood pressure and reduces cardiovascular risk
- Angina Pectoris: Reduces frequency and severity of chest pain
- Heart Failure: Improves survival and symptoms in chronic heart failure
- Post-Myocardial Infarction: Reduces risk of recurrent heart attacks
- Arrhythmias: Management of certain supraventricular and ventricular arrhythmias
Mechanism of Action
Metoprolol selectively blocks β1-adrenergic receptors in the heart, reducing heart rate (negative chronotropic effect) and contractility (negative inotropic effect). This decreases myocardial oxygen demand, lowers blood pressure, and stabilizes cardiac rhythm. Its cardioselectivity minimizes bronchoconstriction, making it safer in patients with respiratory concerns compared to non-selective beta-blockers.
Pharmacological Information
- Chemical Name: (RS)-1-(Isopropylamino)-3-[4-(2-methoxyethyl)phenoxy]propan-2-ol L-(+)-tartrate (1:1)
- Molecular Formula: C15H25NO3·C4H6O6
- Molecular Weight: 684.8 g/mol (tartrate salt)
- CAS Number: 37350-58-6
- Therapeutic Class: Beta-1 Selective Adrenergic Blocker
- Pharmacological Class: Antihypertensive / Antianginal
- ATC Code: C07AB02
Physical & Chemical Properties
| Property | Description |
|---|---|
| Appearance | White to off-white crystalline powder |
| Solubility | Freely soluble in water; soluble in ethanol; slightly soluble in chloroform |
| Melting Point | 122°C – 126°C (decomposition) |
| pH (1% aqueous solution) | 4.5 – 6.5 |
| Storage | Store below 25°C in a dry, ventilated area, protected from light and moisture |
Technical Specifications
| Parameter | Specification |
|---|---|
| Appearance | White to off-white crystalline powder |
| Identification | IR, UV, and HPLC positive |
| Assay (Purity) | ≥ 99.0% (HPLC) |
| Loss on Drying | ≤ 0.5% |
| Residue on Ignition | ≤ 0.1% |
| Heavy Metals | ≤ 10 ppm |
| Related Substances | ≤ 0.3% (individual impurity) |
| Bulk Density | 0.35 – 0.50 g/mL |
| Tapped Density | 0.50 – 0.65 g/mL |
Applications
Metoprolol Tartrate API is used in:
- Immediate-release and sustained-release tablet formulations
- Combination antihypertensive therapy
- Cardiovascular therapeutic preparations
- Bulk pharmaceutical formulations for export markets
Documentation Provided
- Certificate of Analysis (COA)
- Material Safety Data Sheet (MSDS)
- Technical Data Sheet (TDS)
- Method of Analysis (MOA)
- Stability Data (ICH-compliant)
- Regulatory Dossier / DMF (on request)
Packaging & Export Details
- Available Packs: 1 kg | 5 kg | 10 kg | 25 kg HDPE drums with double poly liners
- Labeling: Product name, batch number, manufacturing/expiry dates, storage instructions
- Shelf Life: 36 months under recommended storage conditions
- Export Markets: Africa, Asia, Latin America, Europe, Middle East
