IRBESARTAN

Irbesartan API is a highly effective angiotensin II receptor blocker (ARB) used in the formulation of medicines for hypertension (high blood pressure) and diabetic nephropathy (kidney disease associated with diabetes). It works by blocking the binding of angiotensin II to its receptor (AT₁ subtype), resulting in vasodilation, reduced secretion of aldosterone, and overall lowering of blood pressure.

Irbesartan is widely used as a first-line therapy in managing hypertension and protecting kidney function in patients with Type 2 Diabetes Mellitus. It provides 24-hour blood pressure control with a single daily dose, offering superior patient compliance and minimal side effects.

At Bluepill Express, Irbesartan API is manufactured under WHO-GMP, ISO, and cGMP-certified facilities, ensuring high purity, consistent assay values, and low impurity levels. The API complies with USP / BP / IP pharmacopoeial standards and is suitable for tablet and capsule formulations, both as a monotherapy and in combination with other antihypertensive agents such as Hydrochlorothiazide.

Therapeutic Applications:

• Management of essential hypertension (high blood pressure)
• Treatment of diabetic nephropathy in Type 2 diabetes
• Reduction of cardiovascular risk and kidney damage
• Effective in monotherapy or combination therapy (e.g., Irbesartan + HCTZ)
• Long-lasting 24-hour blood pressure control

Technical Specifications:

• Chemical Name: Irbesartan
• Molecular Formula: C₂₅H₂₈N₆O
• Molecular Weight: 428.53 g/mol
• CAS Number: 138402-11-6
• Appearance: White to off-white crystalline powder
• Assay (on dried basis): NLT 99.0%
• Solubility: Practically insoluble in water; soluble in methanol and alcohol
• Storage Conditions: Store below 30°C, protected from light and moisture

Pharmacological Action:

Irbesartan acts by selectively blocking angiotensin II type 1 (AT₁) receptors, preventing vasoconstriction and aldosterone secretion. This leads to vasodilation, decreased sodium and water retention, and a reduction in systemic blood pressure. Its long half-life provides consistent therapeutic activity over 24 hours, improving cardiovascular and renal outcomes in hypertensive patients.

Manufacturing & Quality Assurance (by Bluepill Express):

• Manufactured in WHO-GMP, ISO, and cGMP certified facilities
• Complies with USP / BP / IP pharmacopoeial standards
• Supported by COA, MSDS, and DMF documentation
• High purity and low impurity profile suitable for global export
• Tested using advanced analytical methods such as HPLC and IR spectroscopy
• Exported to regulated and semi-regulated markets