IBUPROFEN

Ibuprofen API is a widely used non-steroidal anti-inflammatory drug (NSAID) indicated for the treatment of pain, inflammation, and fever. It is effective in mild to moderate pain relief, including headache, dental pain, musculoskeletal pain, menstrual cramps, and post-operative pain, as well as reducing inflammation in arthritis and other inflammatory disorders.

At Bluepill Express, we are a WHO-GMP, ISO 9001:2015, and cGMP-certified manufacturer and exporter of Ibuprofen Active Pharmaceutical Ingredient (API). Our Ibuprofen API meets USP, BP, IP, and EP pharmacopeial standards, ensuring high purity, excellent stability, and consistent particle size for use in tablets, capsules, suspensions, and combination formulations.

Ibuprofen works by inhibiting cyclooxygenase (COX-1 and COX-2) enzymes, which reduces the synthesis of prostaglandins responsible for pain, fever, and inflammation. Its dual action ensures rapid and effective symptom relief with minimal side effects when used according to recommended doses.

Therapeutic Applications:

• Pain relief: headache, dental pain, musculoskeletal pain
• Anti-inflammatory: rheumatoid arthritis, osteoarthritis, and other inflammatory disorders
• Antipyretic: fever reduction in adults and children
• Dysmenorrhea: relief from menstrual cramps
• Post-operative pain management
• Combination therapies with paracetamol or other analgesics

Mechanism of Action:

Ibuprofen is a non-selective inhibitor of COX enzymes (COX-1 and COX-2). By blocking prostaglandin synthesis, it reduces pain perception, inflammation, and fever. It is rapidly absorbed orally and exhibits high bioavailability, making it suitable for oral solid and liquid formulations.

Technical Specifications:

• Chemical Name: (RS)-2-(4-(2-methylpropyl)phenyl)propanoic acid
• Molecular Formula: C₁₃H₁₈O₂
• Molecular Weight: 206.28 g/mol
• CAS Number: 15687-27-1
• Description: White to off-white crystalline powder
• Assay (on dried basis): NLT 98.0% and NMT 102.0%
• Melting Point: 75°C – 78°C
• Solubility: Slightly soluble in water; freely soluble in ethanol, methanol, and acetone
• Storage Conditions: Store in a cool, dry place below 30°C, protected from light and moisture

Pharmacological Classification:

• Therapeutic Class: Non-Steroidal Anti-Inflammatory Drug (NSAID)
• Pharmacopoeial Standards: IP / BP / USP / EP
• Dosage Form Applications:
  • Tablets (200 mg, 400 mg, 600 mg, 800 mg)
  • Capsules and soft gels
  • Oral suspensions and syrups
  • Topical gels and combination formulations

Quality & Manufacturing – Bluepill Express Standards:

• Produced in WHO-GMP and ISO-certified facilities
• High assay purity (≥99%) with controlled impurity levels
• Verified using HPLC, UV, and IR spectroscopy
• Batch-to-batch reproducibility ensuring consistent quality
• Full regulatory documentation: COA, MSDS, and DMF available
• Controlled environment production ensures long-term stability and compliance

Advantages of Bluepill Express Ibuprofen API:

• High purity and crystallinity for effective formulation
• Regulatory-ready API suitable for global markets
• Consistent particle size and flow properties for tableting and encapsulation
• Bulk supply capability with flexible packaging options
• Long shelf-life under recommended storage

Packaging & Export Details:

• Packaging Sizes: 1 kg / 5 kg / 25 kg HDPE drums with LDPE inner liner
• Shelf Life: 3 years under recommended storage conditions
• Labeling: Compliant with pharmacopeial and international export regulations
• Export Markets: Europe, Africa, Asia-Pacific, Middle East, Latin America
• Documentation Provided:
  • Certificate of Analysis (COA)
  • Material Safety Data Sheet (MSDS)
  • Drug Master File (DMF – on request)
  • Stability and regulatory compliance certificates