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Hyoscine Hydrobromide API, also known as Scopolamine Hydrobromide, is a potent anticholinergic and antispasmodic active pharmaceutical ingredient (API) used for the prevention of motion sickness, nausea, vomiting, and smooth muscle spasms of the gastrointestinal and genitourinary tracts. It acts by blocking the action of acetylcholine at parasympathetic sites in smooth muscles, secretory glands, and the central nervous system, providing relief from spasmodic and motion-related symptoms.
At Bluepill Express, Hyoscine Hydrobromide API is produced under WHO-GMP, ISO 9001:2015, and cGMP certified manufacturing standards. Our high-purity API conforms to USP / BP / IP pharmacopoeial specifications and is available in both anhydrous and trihydrate forms, making it suitable for a range of oral, injectable, and transdermal formulations.
This API is globally demanded for use in antiemetic tablets, motion sickness patches, preoperative medication, and gastrointestinal disorder treatments. Bluepill Express ensures the product is chemically stable, pharmaceutically active, and fully supported with DMF, COA, and MSDS documentation for international regulatory submissions.
Therapeutic Applications:
- Prevention and control of motion sickness (nausea and vomiting)
- Relief from gastrointestinal, biliary, and urinary tract spasms
- Used in pre-anesthetic medication to reduce salivation and secretions
- Management of Parkinsonism symptoms and irritable bowel syndrome (IBS)
- Employed in ophthalmic formulations for mydriasis and cycloplegia
Technical Specifications:
- Chemical Name: Hyoscine Hydrobromide (Scopolamine Hydrobromide)
- Molecular Formula: C₁₇H₂₂BrNO₄
- Molecular Weight: 384.27 g/mol
- CAS Number: 6533-68-2
- Appearance: White or almost white crystalline powder
- Assay (on dried basis): NLT 98.0%
- Solubility: Freely soluble in water and alcohol
- Melting Point: 200°C (decomposes)
- pH (1% aqueous solution): 4.5 – 6.5
- Storage Conditions: Store in a cool, dry, light-protected place below 30°C
Pharmacological Action:
Hyoscine Hydrobromide acts as a competitive antagonist of acetylcholine at muscarinic receptors, inhibiting parasympathetic nerve impulses. By reducing activity in the vestibular system and vomiting center, it effectively prevents motion-induced nausea and vomiting. Its antispasmodic action helps relax smooth muscles in the GI and urinary tracts, reducing cramping and discomfort.
It also crosses the blood-brain barrier, exerting central anticholinergic effects, which make it useful in pre-anesthetic sedation and certain neurological disorders.
Manufacturing & Quality Assurance (by Bluepill Express):
- Manufactured under WHO-GMP, ISO, and cGMP-certified facilities
- Meets USP / BP / IP pharmacopoeial standards
- Supplied with Certificate of Analysis (COA), MSDS, and DMF
- Stringent testing via HPLC, IR spectroscopy, and UV analysis
- Superior stability and assay uniformity across all batches
- Exported to regulated and semi-regulated markets across Asia, Africa, and the Middle East
Advantages of Bluepill Express Hyoscine Hydrobromide API:
- High-purity crystalline API for oral, parenteral, and transdermal dosage forms
- Consistent potency, solubility, and bioavailability
- Excellent stability under storage and formulation conditions
- Compliant with global pharmacopoeial and regulatory requirements
- Reliable bulk supply and documentation support for export partners
