FUROSEMIDE

Furosemide API is a highly effective loop diuretic widely used for the treatment of edema, hypertension, and congestive heart failure. It acts primarily on the ascending loop of Henle in the kidneys, inhibiting the sodium-potassium-chloride (Na⁺/K⁺/2Cl⁻) co-transporter, leading to rapid excretion of sodium, chloride, and water. This action helps in reducing fluid overload and controlling blood pressure.

Furosemide is a first-line therapy for edema associated with heart failure, liver cirrhosis, and kidney disorders, and is also used in hypertensive patients requiring potent diuretic action. At Bluepill Express, Furosemide API is manufactured under WHO-GMP, ISO, and cGMP-certified facilities, ensuring high purity, precise assay, and consistent stability, making it suitable for tablet, oral solution, and injectable formulations.

Therapeutic Applications:

• Management of edema due to heart failure, renal impairment, or liver cirrhosis
• Treatment of hypertension requiring loop diuretic therapy
• Relief of fluid retention in acute pulmonary edema
• Used in hypercalcemia to promote calcium excretion
• Formulated in tablets, oral liquids, and injectable dosage forms

Technical Specifications:

• Chemical Name: Furosemide
• Molecular Formula: C₁₂H₁₁ClN₂O₅S
• Molecular Weight: 330.74 g/mol
• CAS Number: 54-31-9
• Appearance: White to off-white crystalline powder
• Assay (on dried basis): NLT 99.0%
• Solubility: Freely soluble in sodium hydroxide, slightly soluble in water
• Melting Point: 222–223°C
• Storage Conditions: Store below 30°C in a dry, light-protected environment

Pharmacological Action:

Furosemide inhibits the Na⁺/K⁺/2Cl⁻ co-transporter in the thick ascending limb of the loop of Henle, causing rapid diuresis and natriuresis. By reducing blood volume and venous pressure, it helps alleviate edema, lower blood pressure, and prevent fluid accumulation in lungs and extremities. Its rapid onset of action makes it highly effective in acute conditions requiring immediate diuretic effect.

Manufacturing & Quality Assurance (by Bluepill Express):

• Produced in WHO-GMP, ISO, and cGMP-certified facilities
• Complies with USP / BP / IP pharmacopoeial standards
• Supported with COA, MSDS, and DMF documentation for global export compliance
• Each batch validated for assay, impurity profile, and particle size distribution
• High purity, stable, and suitable for large-scale pharmaceutical production
• Exported to regulated and semi-regulated international markets

Advantages of Bluepill Express Furosemide API:

• High-quality crystalline API with consistent performance
• Ideal for oral and parenteral dosage forms
• Ensures batch-to-batch uniformity for industrial formulations
• Compliant with international regulatory requirements
• Reliable global supply chain with regulatory documentation support