IndiaMart
FIEO
Etoricoxib is a potent, selective COX-2 inhibitor belonging to the NSAID class. It is widely used for pain management, inflammation reduction, and treatment of arthritis, offering gastrointestinal safety compared to traditional NSAIDs.
At Bluepill Express, we produce high-purity Etoricoxib API under WHO-GMP, ISO 9001:2015, and cGMP-certified facilities, compliant with IP/BP/USP/EP standards. Our Etoricoxib API features excellent stability, high assay value, and low impurity content, making it ideal for global pharmaceutical formulations.
Therapeutic Uses
- Relief of pain and inflammation in osteoarthritis and rheumatoid arthritis
- Treatment of ankylosing spondylitis
- Management of acute musculoskeletal pain
- Reduces postoperative pain
- Effective in gout flare-ups
Mechanism of Action
Etoricoxib selectively inhibits cyclooxygenase-2 (COX-2) enzyme, reducing prostaglandin synthesis at sites of inflammation.
Key effects include:
- Anti-inflammatory and analgesic action
- Minimal effect on COX-1, reducing gastrointestinal irritation
- Provides targeted pain relief with improved tolerability
Pharmacological Information
| Parameter | Details |
|---|---|
| Chemical Name | 5-chloro-6’-methyl-3-[4-(methylsulfonyl)phenyl]-2,3’-bipyridine |
| Molecular Formula | C18H15ClN2O2S |
| Molecular Weight | 358.84 g/mol |
| CAS Number | 222627-90-4 |
| Therapeutic Category | NSAID / COX-2 Inhibitor / Analgesic |
| Pharmacopoeial Standards | IP / BP / USP / EP |
Physical & Chemical Properties
| Property | Description |
|---|---|
| Appearance | White to off-white crystalline powder |
| Odor | Odorless |
| Melting Point | 140°C – 142°C |
| Solubility | Practically insoluble in water; soluble in DMSO, ethanol, and methanol |
| Assay (on dried basis) | 98.0% – 102.0% |
| pH (1% suspension) | 5.5 – 7.0 |
Technical Specifications
| Test | Specification |
|---|---|
| Appearance | White crystalline powder |
| Identification | IR / UV / HPLC – Complies |
| Assay (Purity) | 98.0% – 102.0% |
| Loss on Drying | ≤ 1.0% |
| Residue on Ignition | ≤ 0.1% |
| Related Substances | ≤ 0.3% (individual), ≤ 0.5% (total) |
| Heavy Metals | ≤ 10 ppm |
| Storage | Store below 25°C, protected from moisture and light |
Applications
- Formulation of tablets and capsules for arthritis and pain management
- Used in acute pain relief formulations
- Can be combined with Paracetamol or other analgesics for synergistic effect
- Suitable for generic and branded pharmaceutical products
Documentation Provided
- Certificate of Analysis (COA)
- Material Safety Data Sheet (MSDS)
- Technical Data Sheet (TDS)
- Stability Data (ICH guidelines)
- Drug Master File (DMF) – available on request
Packaging & Export Details
| Packaging Type | Net Weight |
|---|---|
| HDPE Drum | 25 kg |
| Fiber Drum | 25 kg |
| LDPE Inner Bag | 1 kg / 5 kg / 10 kg |
Labeling Includes: Product name, batch number, manufacturing & expiry date, net weight, and storage instructions.
Shelf Life: 5 years (stored below 25°C)
Export Markets: Africa, Asia, Middle East, Latin America, CIS
