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Doxazosin Mesilate is a selective alpha-1 adrenergic receptor blocker used for the treatment of hypertension and benign prostatic hyperplasia (BPH). It helps relax vascular smooth muscles and the muscles of the prostate and bladder neck, improving blood flow and urinary function.
At Bluepill Express, we specialize in the manufacturing and export of high-purity Doxazosin Mesilate API under WHO-GMP, ISO 9001:2015, and cGMP certified facilities. Our API is produced using advanced synthesis and purification technologies to ensure excellent purity, stability, and batch consistency. It conforms to global pharmacopeial standards — IP, BP, USP, and EP — making it suitable for international pharmaceutical formulations.
Bluepill Express provides Doxazosin Mesilate API to regulated and semi-regulated markets worldwide, supporting formulation of film-coated tablets, extended-release tablets, and combination drugs for cardiovascular and urological applications.
Therapeutic Uses
- Treatment of hypertension (high blood pressure)
- Management of benign prostatic hyperplasia (BPH)
- Improves urinary flow rate and relieves bladder outlet obstruction
- Used as part of combination therapy with other antihypertensives
Mechanism of Action
Doxazosin Mesilate selectively inhibits postsynaptic alpha-1 adrenergic receptors in vascular smooth muscle and prostate tissues. This blockade reduces vascular resistance, leading to vasodilation and decreased blood pressure, while also relaxing the bladder neck and prostate to improve urine flow in BPH patients.
Pharmacological Information
- Chemical Name: Doxazosin Mesilate
- Molecular Formula: C₂₃H₂₅N₅O₅·CH₄O₃S
- Molecular Weight: 547.6 g/mol
- CAS Number: 77883-43-3
- Therapeutic Category: Antihypertensive / Alpha-1 Blocker
- Pharmacopoeial Grade: IP / BP / USP / EP
- Appearance: White to off-white crystalline powder
- Solubility: Soluble in methanol; slightly soluble in water
- Melting Point: 272°C – 274°C
- Storage: Store below 25°C in a cool, dry place, protected from light and moisture
Technical Specifications
| Test | Specification |
|---|---|
| Appearance | White to off-white powder |
| Identification | IR spectrum matches standard |
| Assay (Purity) | ≥ 99.0% (HPLC) |
| Related Substances | ≤ 0.2% (individual impurity) |
| Loss on Drying | ≤ 0.5% |
| Residue on Ignition | ≤ 0.1% |
| pH (1% solution) | 5.0 – 6.0 |
| Heavy Metals | ≤ 10 ppm |
| Specific Rotation | Conforms to standard |
Pharmacological Category
- Therapeutic Class: Antihypertensive / Urological Agent
- Pharmacological Class: Selective Alpha-1 Adrenergic Antagonist
- ATC Code: C02CA04
Applications in Formulations
Doxazosin Mesilate API from Bluepill Express is ideal for:
- Tablets (1 mg, 2 mg, 4 mg, 8 mg)
- Extended-release formulations
- Fixed-dose combinations with other antihypertensives
Its excellent compressibility and flow properties make it highly suitable for direct compression or wet granulation processes in tablet manufacturing.
Manufacturing & Quality Assurance
Bluepill Express ensures world-class manufacturing under:
- WHO-GMP, ISO 9001:2015, and cGMP-certified facilities
- Validated synthesis and crystallization processes
- In-process quality control (IPQC) for every batch
- HPLC, GC, and IR-based analytical validation
- Comprehensive documentation support for global regulatory submissions
Documentation Provided
- Certificate of Analysis (COA)
- Material Safety Data Sheet (MSDS)
- Technical Data Sheet (TDS)
- Stability Data (as per ICH guidelines)
- Method of Analysis (MOA)
- Non-GMO / BSE / TSE / Allergen-free declaration
Packaging & Export Details
- Packaging Sizes: 1 kg | 5 kg | 10 kg | 25 kg HDPE drums with inner poly liners
- Labeling: As per international export norms with batch and expiry details
- Shelf Life: 3 years (36 months) under recommended storage conditions
- Export Markets: Africa, Asia, Latin America, Middle East, Europe
