CIMETIDINE

Cimetidine is a potent H₂ receptor antagonist (H₂ blocker) used to reduce stomach acid production. It is widely prescribed for the treatment and prevention of gastric ulcers, duodenal ulcers, gastroesophageal reflux disease (GERD), and Zollinger-Ellison syndrome. Cimetidine effectively decreases acid secretion in the stomach lining, promoting healing of ulcers and providing lasting relief from acid-related discomfort.

At Bluepill Express, we manufacture and export pharma-grade Cimetidine API with superior assay purity, consistent stability, and pharmacopeial compliance. Produced under WHO-GMP, ISO, and cGMP-certified facilities, our Cimetidine API conforms to IP, BP, USP, and EP standards — ensuring suitability for regulated and semi-regulated global markets.

Our advanced purification technology guarantees low impurity levels, uniform particle size, and excellent flow properties, making it ideal for both solid oral and injectable dosage formulations.

Therapeutic Applications:

• Peptic and Duodenal Ulcers
• Gastroesophageal Reflux Disease (GERD)
• Zollinger-Ellison Syndrome
• Acid Indigestion and Heartburn
• Prevention of Stress-Induced Ulcers

Mechanism of Action:

Cimetidine works by selectively blocking H₂ receptors on gastric parietal cells, reducing both basal and stimulated gastric acid secretion. This helps maintain balanced stomach acidity and supports mucosal healing, effectively preventing ulcer recurrence.

Technical Specifications:

• Chemical Name: N”-Cyano-N-methyl-N’-[2-[[(5-methyl-1H-imidazol-4-yl)methyl]thio]ethyl]guanidine
• Molecular Formula: C₁₀H₁₆N₆S
• Molecular Weight: 252.34 g/mol
• CAS Number: 51481-61-9
• Appearance: White to off-white crystalline powder
• Assay (on dried basis): NLT 98.0% and NMT 102.0%
• Solubility: Freely soluble in water and alcohol; slightly soluble in chloroform
• Melting Point: 140°C – 145°C
• Storage Conditions: Store below 30°C, away from light and moisture

Pharmacological Classification:

• Therapeutic Class: H₂ Receptor Antagonist / Anti-Ulcer Agent
• Pharmacopoeial Standards: IP / BP / USP / EP
• Common Formulations: Tablets (200 mg, 400 mg, 800 mg), Syrups, Injections

Manufacturing Excellence – Bluepill Express:

• Manufactured under WHO-GMP, ISO 9001:2015, and cGMP-certified units
• Analytical testing performed using HPLC, FTIR, and UV methods
• Low impurity and solvent residue profile
• Batch-to-batch consistency and verified stability data
• Regulatory-ready export documentation available on demand

Advantages of Bluepill Express Cimetidine API:

• Complies with IP/BP/USP/EP pharmacopeias
• High assay value (≥99%) and superior purity
• Low hygroscopicity and enhanced stability
• Suitable for solid, liquid, and parenteral formulations
• COA, MSDS, TDS, and DMF available for all shipments

Packaging & Export Details:

• Packaging Sizes: 5 kg, 10 kg, 25 kg HDPE drums with double inner liners
• Labeling: Export-compliant, batch traceable
• Shelf Life: 36 months from manufacturing date
• Export Markets: Africa, Asia, Middle East, Europe, and Latin America
• Documentation Provided:
  • Certificate of Analysis (COA)
  • Material Safety Data Sheet (MSDS)
  • Stability Data
  • Technical Data Sheet (TDS)
  • Drug Master File (DMF) available upon request