Celecoxib is a selective cyclooxygenase-2 (COX-2) inhibitor belonging to the class of nonsteroidal anti-inflammatory drugs (NSAIDs). It is widely used for pain relief, inflammation reduction, and management of arthritis without significantly affecting the gastrointestinal tract, making it a preferred alternative to traditional NSAIDs.
At Bluepill Express, we manufacture high-quality Celecoxib API with exceptional purity, particle uniformity, and consistent potency, ensuring superior performance in formulations. Our production follows WHO-GMP, ISO 9001:2015, and cGMP guidelines to meet IP/BP/USP/EP standards for global pharmaceutical markets.
Therapeutic Uses
- Relief from pain and inflammation in osteoarthritis and rheumatoid arthritis
- Treatment of ankylosing spondylitis
- Management of acute pain and primary dysmenorrhea
- Useful in juvenile idiopathic arthritis
- Reduces postoperative and musculoskeletal pain
Mechanism of Action
Celecoxib works by selectively inhibiting the cyclooxygenase-2 (COX-2) enzyme, responsible for prostaglandin synthesis during inflammation.
This selective inhibition results in:
- Decreased inflammation and pain
- Minimal impact on COX-1 enzyme (thus less gastric irritation and ulcers)
- Improved tolerability and safety profile compared to traditional NSAIDs
Pharmacological Information
| Parameter | Details |
|---|---|
| Chemical Name | 4-[5-(4-Methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl] benzenesulfonamide |
| Molecular Formula | C17H14F3N3O2S |
| Molecular Weight | 381.38 g/mol |
| CAS Number | 169590-42-5 |
| Therapeutic Category | NSAID / COX-2 Inhibitor / Analgesic |
| Pharmacopoeial Standards | IP / BP / USP / EP |
Physical & Chemical Properties
| Property | Description |
|---|---|
| Appearance | White to off-white crystalline powder |
| Odor | Odorless |
| Melting Point | 157°C – 159°C |
| Solubility | Practically insoluble in water, freely soluble in methanol and ethanol |
| Assay (on dried basis) | 98.0% – 102.0% |
| pH (1% suspension) | 6.0 – 8.0 |
Technical Specifications
| Test | Specification |
|---|---|
| Appearance | White crystalline powder |
| Identification | IR / UV / HPLC – Complies |
| Assay (Purity) | 98.0% – 102.0% |
| Loss on Drying | ≤ 1.0% |
| Residue on Ignition | ≤ 0.1% |
| Related Substances | ≤ 0.3% (individual), ≤ 0.5% (total) |
| Heavy Metals | ≤ 10 ppm |
| Storage | Store below 25°C in airtight containers, away from light and moisture |
Applications
- Used in capsules, tablets, and suspension formulations for pain and inflammation relief
- Combines well with paracetamol or tramadol for enhanced pain management
- Formulated for acute and chronic arthritis conditions
- Ideal for post-surgical pain formulations
Documentation Provided
- Certificate of Analysis (COA)
- Material Safety Data Sheet (MSDS)
- Technical Data Sheet (TDS)
- Stability Data (ICH guidelines)
- Drug Master File (DMF) – available upon request
Packaging & Export Details
| Packaging Type | Net Weight |
|---|---|
| HDPE Drum | 25 kg |
| Fiber Drum | 25 kg |
| LDPE Inner Bag | 1 kg / 5 kg / 10 kg |
Labeling Includes: Product name, batch number, manufacturing & expiry date, net weight, and storage instructions.
Shelf Life: 5 years (stored below 25°C)
Export Markets: Africa, Middle East, Asia, CIS, and South America
