CARBIDOPA

Carbidopa is a peripheral dopa-decarboxylase inhibitor widely used in combination with Levodopa for the treatment of Parkinson’s disease and dopamine-responsive dystonia. It enhances the therapeutic efficacy of Levodopa by preventing its peripheral metabolism, allowing more of the active drug to reach the brain and thus reducing motor symptoms and side effects such as nausea and hypotension.

At Bluepill Express, we are a WHO-GMP, ISO, and cGMP-certified API manufacturer and exporter, offering high-purity Carbidopa API that meets IP, BP, USP, and EP specifications. Our product is developed under strict quality control protocols to ensure high assay value (≥99%), low impurities, and consistent physicochemical characteristics for formulation stability.

Therapeutic Applications:

• Used in combination with Levodopa for Parkinson’s disease treatment
• Reduces nausea, vomiting, and cardiovascular side effects associated with Levodopa alone
• Improves dopamine availability in the central nervous system
• Enhances motor control and daily function in Parkinson’s patients

Mechanism of Action:

Carbidopa inhibits the enzyme aromatic L-amino acid decarboxylase (AADC) outside the central nervous system. This prevents the premature conversion of Levodopa to dopamine in peripheral tissues, ensuring that a higher concentration of Levodopa reaches the brain, where it can be converted into dopamine and exert its therapeutic effect.

Technical Specifications:

• Chemical Name: (2S)-3-(3,4-Dihydroxyphenyl)-2-hydrazino-2-methylpropanoic acid monohydrate
• Molecular Formula: C₁₀H₁₄N₂O₄·H₂O
• Molecular Weight: 244.24 g/mol
• CAS Number: 38821-49-7
• Appearance: White or off-white crystalline powder
• Assay (on dried basis): NLT 98.0% and NMT 101.0%
• Solubility: Slightly soluble in water; insoluble in ethanol and ether
• Melting Point: 203°C – 210°C
• Storage Conditions: Store in a cool, dry place below 25°C, protected from moisture and light

Pharmacological Classification:

• Therapeutic Class: Antiparkinson Agent
• Pharmacopoeial Standards: IP / BP / USP / EP
• Dosage Form Applications:
  • Tablets (with Levodopa)
  • Controlled-release combinations
  • Dispersible and extended-release formulations

Manufacturing & Quality Standards – Bluepill Express:

• Produced under WHO-GMP, ISO 9001:2015, and cGMP certified conditions
• High assay purity (≥99%) with minimal impurity profile
• Comprehensive analytical validation: HPLC, GC, FTIR, and LC-MS testing
• Batch reproducibility with optimized particle size distribution
• DMF-ready documentation for regulatory submissions
• Complies with ICH Q7 and Q3A/B impurity guidelines

Advantages of Bluepill Express Carbidopa API:

• Pharmacopeial-grade quality with high stability
• Regulatory-compliant documentation (COA, MSDS, DMF)
• Consistent particle morphology ensuring better blend uniformity
• Flexible export packaging and global logistics support
• Customized bulk supply options for large-scale formulations

Packaging & Export Details:

• Packaging Sizes: 1 kg, 5 kg, and 25 kg HDPE drums with double LDPE liners
• Labeling: As per international export and pharmacopeial norms
• Shelf Life: 36 months under recommended conditions
• Export Regions: Africa, Asia, Middle East, Europe, and Latin America
• Documentation Support:
  • Certificate of Analysis (COA)
  • Material Safety Data Sheet (MSDS)
  • Stability Data
  • Drug Master File (DMF)