CAFFEINE ANHYDROUS

Caffeine Anhydrous is a pharmaceutically active xanthine derivative known for its central nervous system (CNS) stimulant properties. It enhances alertness, reduces fatigue, and improves mental focus and physical endurance. It is widely used in pharmaceutical formulations, nutraceuticals, energy supplements, and analgesic combinations.

At Bluepill Express, we manufacture and export high-purity Caffeine Anhydrous API that meets IP, BP, USP, and EP standards. Our production facilities are WHO-GMP, ISO 9001:2015, and cGMP-certified, ensuring exceptional assay purity (≥99%), uniform particle size, and excellent solubility characteristics for superior formulation performance.

Caffeine Anhydrous is a dehydrated crystalline form of caffeine, making it more potent and stable than regular caffeine. It is a key ingredient in pain relievers, weight management tablets, sports nutrition supplements, and energy formulations.

Therapeutic Applications:

• Used as a CNS stimulant to reduce drowsiness and improve alertness
• Enhances mental and physical performance
• Component in analgesic formulations for headache and migraine relief
• Used in combination with painkillers like Paracetamol and Aspirin
• Ingredient in weight-loss and pre-workout supplements

Mechanism of Action:

Caffeine Anhydrous acts as a competitive antagonist of adenosine receptors in the brain, preventing adenosine-induced drowsiness. It also stimulates the release of dopamine and norepinephrine, increasing energy, focus, and alertness. Additionally, it promotes lipolysis, aiding in fat metabolism and thermogenesis.

Technical Specifications:

• Chemical Name: 1,3,7-Trimethylxanthine
• Molecular Formula: C₈H₁₀N₄O₂
• Molecular Weight: 194.19 g/mol
• CAS Number: 58-08-2
• Appearance: White or off-white crystalline powder
• Assay (on dried basis): NLT 98.5% and NMT 101.0%
• Solubility: Slightly soluble in water; freely soluble in chloroform and ethanol
• Melting Point: 235°C – 238°C (decomposes)
• Storage Conditions: Store below 25°C in a cool, dry place, protected from light and moisture

Pharmacological Classification:

• Therapeutic Class: Central Nervous System Stimulant / Analgesic Adjunct
• Pharmacopoeial Standards: IP / BP / USP / EP
• Dosage Form Applications: Tablets, Capsules, Energy Drinks, Powders, Nutraceuticals

Manufacturing Excellence – Bluepill Express:

• Manufactured under WHO-GMP, ISO, and cGMP certifications
• High assay purity (≥99%) with consistent crystal morphology
• Validated analytical methods using HPLC and GC
• DMF-ready documentation available for regulatory submissions
• Low moisture content ensuring extended shelf life
• Suitable for pharmaceutical and nutraceutical formulations

Advantages of Bluepill Express Caffeine Anhydrous API:

• Pharmacopeial-grade compliant with global standards
• Excellent flowability and compressibility for direct tablet compression
• Custom particle size options (micronized/non-micronized)
• Low residue and solvent-free manufacturing process
• DMF, COA, and MSDS documentation support for exports

Packaging & Export Details:

• Standard Pack Sizes: 5 kg, 10 kg, 25 kg HDPE drums with double LDPE liners
• Labeling: In accordance with pharmacopeial and export norms
• Shelf Life: 36 months from date of manufacture
• Export Markets: Africa, Asia, Europe, Latin America, Middle East
• Documentation Provided:
  • Certificate of Analysis (COA)
  • Material Safety Data Sheet (MSDS)
  • Stability Data
  • Technical Data Sheet (TDS)
  • Drug Master File (DMF) upon request