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Caffeine Anhydrous Granular is a high-purity stimulant API derived from xanthine alkaloids, widely used in pharmaceutical, nutraceutical, and energy formulations. It acts as a central nervous system (CNS) stimulant, reducing fatigue, improving alertness, and enhancing concentration.
At Bluepill Express, we manufacture and export Caffeine Anhydrous Granular that meets IP / BP / USP / EP pharmacopeial standards. Our granular-grade caffeine provides excellent flowability, compressibility, and uniform particle size, making it ideal for tablet and capsule formulations, as well as sports nutrition and dietary supplement products.
Produced under WHO-GMP, ISO 9001:2015, and cGMP guidelines, our Caffeine Anhydrous Granular is recognized globally for its purity, consistency, and superior performance across pharmaceutical and nutraceutical applications.
Therapeutic & Functional Uses
- Pharmaceutical Applications:
- Treatment of migraine and tension-type headaches (with aspirin or ergotamine)
- Used in combination with analgesics and antihistamines
- Improves mental alertness and combats fatigue
- Nutraceutical & Sports Applications:
- Included in energy drinks, pre-workout blends, and weight management products
- Supports endurance and performance enhancement
Mechanism of Action
Caffeine acts as a non-selective adenosine receptor antagonist, blocking the A1 and A2A receptors in the brain. This reduces the sedative effects of adenosine and stimulates the release of neurotransmitters such as dopamine, norepinephrine, and acetylcholine, promoting wakefulness, focus, and increased energy metabolism.
Pharmacological Information
- Chemical Name: 1,3,7-Trimethylxanthine
- Synonyms: Caffeine, Methyltheobromine, Guaranine
- Molecular Formula: C8H10N4O2
- Molecular Weight: 194.19 g/mol
- CAS Number: 58-08-2
- Appearance: White or off-white granular crystalline powder
- Taste: Slightly bitter
- Odor: Odorless
- Solubility: Soluble in water and alcohol; slightly soluble in chloroform
- Storage: Store below 25°C, in a cool, dry, and well-ventilated area away from moisture
Technical Specifications
| Parameter | Specification |
|---|---|
| Appearance | White granular crystalline powder |
| Identification | Positive for caffeine by UV/IR |
| Assay (Purity) | 98.5% – 101.0% (on anhydrous basis, HPLC) |
| Loss on Drying | ≤ 0.5% |
| Residue on Ignition | ≤ 0.1% |
| pH (1% solution) | 5.0 – 7.0 |
| Heavy Metals | ≤ 10 ppm |
| Related Substances | ≤ 0.2% (individual impurity) |
| Particle Size | Granular grade (optimized for tablet compression) |
| Bulk Density | 0.45 – 0.55 g/mL |
| Tapped Density | 0.60 – 0.70 g/mL |
Pharmacological Category
- Therapeutic Class: CNS Stimulant / Analgesic Adjuvant
- Pharmacological Class: Xanthine Derivative
- ATC Code: N06BC01
Applications
Caffeine Anhydrous Granular API is extensively used in:
- Pharmaceutical tablets (with Paracetamol, Aspirin, or Ibuprofen)
- Energy and pre-workout supplements
- Effervescent tablets and sports nutrition powders
- Pain relief combinations for tension and migraine headaches
- Alertness and focus-enhancing formulations
Manufacturing Excellence at Bluepill Express
- Manufactured in WHO-GMP and ISO-certified facilities
- High-purity synthesis with controlled granulation process
- HPLC and GC analytical validation for every batch
- Complies with IP, BP, USP, and EP standards
- Non-GMO, allergen-free, BSE/TSE-free product
- Full traceability and regulatory documentation provided
Documentation Provided
- Certificate of Analysis (COA)
- Material Safety Data Sheet (MSDS)
- Technical Data Sheet (TDS)
- Stability Study Report (on request)
- Method of Analysis (MOA)
- Regulatory Dossier / DMF (available upon request)
Packaging & Export Details
- Available Packs: 1 kg | 5 kg | 10 kg | 25 kg HDPE drums with double poly liners
- Labeling: Batch number, manufacturing & expiry date, storage instructions, and net weight
- Shelf Life: 36 months (under recommended storage conditions)
- Export Markets: Africa, Asia, Latin America, Europe, and the Middle East
