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Bendroflumethiazide is a high-quality thiazide diuretic Active Pharmaceutical Ingredient (API) primarily used for the management of hypertension and edema associated with heart failure, renal, or hepatic disorders. It acts by inhibiting sodium reabsorption in the distal convoluted tubules of the kidneys, leading to increased excretion of sodium and water, while preserving potassium balance to a certain extent.
Bluepill Express manufactures Bendroflumethiazide under WHO-GMP, ISO, and cGMP-certified facilities, ensuring exceptional purity, stability, and batch-to-batch consistency. The API is widely used in tablet and capsule formulations and meets IP, BP, USP, and EP pharmacopoeial standards.
Therapeutic Classification
- Thiazide diuretic
- Antihypertensive agent
- Edema management
- Cardiovascular and renal therapy
Mechanism of Action
Bendroflumethiazide inhibits the sodium-chloride symporter in the distal convoluted tubule, reducing sodium and water reabsorption. This decreases blood volume and blood pressure, reduces peripheral edema, and enhances renal excretion of chloride and bicarbonate.
Chemical & Composition Information
| Parameter | Details |
|---|---|
| Chemical Name | 3-benzyl-1,2-dihydro-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide |
| Molecular Formula | C14H20ClN3O4S2 |
| Molecular Weight | 364.88 g/mol |
| CAS Number | 73-38-9 |
| Form | Crystalline powder |
| Pharmacopoeial Standards | IP / BP / USP / EP |
| Therapeutic Class | Thiazide diuretic |
Physical & Chemical Properties
- Appearance: White to off-white crystalline powder
- Solubility: Slightly soluble in water; soluble in dimethylformamide and ethanol
- Melting Point: 267–272°C
- Stability: Chemically stable under recommended storage conditions
Technical Specifications (Bluepill Express Standards)
| Parameter | Specification |
|---|---|
| Assay | 98.0% – 102.0% |
| Identification | IR and HPLC spectra match reference standard |
| Water Content (KF) | ≤ 1.0% |
| Residue on Ignition | ≤ 0.1% |
| Related Substances | ≤ 0.5% individual impurity, ≤ 1.0% total impurities |
| Bulk Density | 0.35 – 0.55 g/ml |
| Particle Size Distribution | D90 < 250 μm (customizable) |
| Heavy Metals | ≤ 10 ppm |
| Microbial Limits | Complies with pharmacopeial standards |
Pharmacological Applications
- Management of hypertension
- Treatment of edema due to congestive heart failure
- Secondary therapy in renal and hepatic disorders
- Used in combination therapy with other antihypertensive agents
Dosage Forms
- Tablets: 2.5 mg, 5 mg, 10 mg
- Combination tablets with beta-blockers or other antihypertensives
Manufacturing Excellence – Bluepill Express
- WHO-GMP, ISO 9001:2015, and cGMP certified
- Controlled crystallization to ensure high purity
- Batch-to-batch uniformity in particle size and moisture content
- Full documentation: COA, MSDS, TDS, and DMF-ready dossiers
- Global export-ready API with reliable delivery
Packaging & Storage
- Packaged in HDPE drums / fiber containers with PE liners
- Pack sizes: 5 kg / 10 kg / 25 kg
- Shelf Life: 36 months
- Storage: Store below 25°C in a dry, cool environment, away from light and moisture
Safety & Handling
- Use gloves, mask, and goggles while handling
- Avoid inhalation, ingestion, and direct skin or eye contact
- Follow GMP and EHS guidelines for handling and disposal
