ATENOLOL

Atenolol is a selective beta-1 adrenergic receptor blocker (β1-blocker) widely used in the treatment of hypertension, angina pectoris, and cardiac arrhythmias. As a cornerstone medication in cardiovascular therapy, Atenolol effectively reduces heart rate, cardiac output, and blood pressure, improving cardiac efficiency and reducing the risk of heart attacks.

At Bluepill Express, we manufacture and export pharma-grade Atenolol API conforming to IP, BP, USP, and EP standards. Our advanced manufacturing units are WHO-GMP, ISO 9001:2015, and cGMP-certified, ensuring superior purity, uniform particle size, and high stability suitable for both oral solid and liquid dosage formulations.

Atenolol is a white crystalline powder, practically insoluble in chloroform and ether but freely soluble in water and methanol. It is one of the most prescribed beta-blockers globally, known for its cardioselective action and minimal central nervous system side effects.

Therapeutic Applications:

• Management of hypertension (high blood pressure)
• Treatment of angina pectoris (chest pain)
• Control of cardiac arrhythmias (irregular heartbeat)
• Prevention of secondary myocardial infarction
• Used in combination antihypertensive formulations

Mechanism of Action:

Atenolol selectively blocks β1-adrenergic receptors in cardiac tissue, reducing sympathetic stimulation of the heart. This results in decreased heart rate, cardiac output, and myocardial oxygen demand. It helps maintain a stable rhythm and lowers blood pressure without significant effect on β2 receptors in the bronchi and vasculature.

Technical Specifications:

• Chemical Name: (RS)-2-[4-[2-Hydroxy-3-(propan-2-ylamino)propoxy]phenyl]acetamide
• Molecular Formula: C₁₄H₂₂N₂O₃
• Molecular Weight: 266.34 g/mol
• CAS Number: 29122-68-7
• Appearance: White or almost white crystalline powder
• Assay (on dried basis): NLT 98.0% and NMT 101.0%
• Solubility: Freely soluble in water, sparingly soluble in ethanol
• Melting Point: 155°C – 158°C
• Storage Conditions: Store below 25°C, protected from light and moisture

Pharmacological Classification:

• Therapeutic Class: Cardioselective Beta-Blocker
• Pharmacopoeial Standards: IP / BP / USP / EP
• Common Formulations: Tablets (25 mg, 50 mg, 100 mg), Oral solutions

Manufacturing Excellence – Bluepill Express:

• Manufactured under WHO-GMP, ISO, and cGMP certified facilities
• High assay purity with validated analytical control methods (HPLC, IR)
• Consistent particle size distribution for uniform blending
• Stable crystalline form for extended shelf life
• Comprehensive documentation support including DMF and COA

Advantages of Bluepill Express Atenolol API:

• Global pharmacopeial compliance (IP/BP/USP/EP)
• Low impurity profile and high batch consistency
• Suitable for fixed-dose combination products
• Regulatory-ready export documentation (DMF, MSDS, TDS)
• Trusted by leading pharmaceutical formulators worldwide

Packaging & Export Details:

• Packaging Sizes: 5 kg, 10 kg, 25 kg HDPE drums with double liners
• Labeling: As per export and pharmacopeial regulations
• Shelf Life: 36 months from manufacturing date
• Export Markets: Africa, Asia, Middle East, Europe, Latin America
• Documentation Provided:
  • Certificate of Analysis (COA)
  • Material Safety Data Sheet (MSDS)
  • Stability Data
  • Technical Data Sheet (TDS)
  • Drug Master File (DMF) on request