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Aspirin (Acetylsalicylic Acid, Crystal Grade 2080-C) is a widely used non-steroidal anti-inflammatory drug (NSAID) with analgesic, antipyretic, and anti-inflammatory properties. It is also extensively employed in cardiovascular therapy for its antiplatelet (blood-thinning) effect, reducing the risk of heart attacks, strokes, and blood clots.
Bluepill Express manufactures high-purity Aspirin Crystal Grade 2080-C API under WHO-GMP, ISO 9001:2015, and cGMP-certified facilities, ensuring consistent quality, stability, and pharmacopoeial compliance for pharmaceutical formulations. This grade is ideal for tablet and capsule production, offering excellent solubility, uniformity, and compressibility.
Therapeutic Uses
- Pain relief: Mild to moderate headaches, muscle pain, and joint pain
- Fever reduction: Antipyretic effect for common colds and flu
- Anti-inflammatory: Reduces inflammation in arthritis and musculoskeletal disorders
- Cardiovascular protection: Low-dose therapy for prevention of heart attacks, strokes, and thromboembolic events
- Combination therapy: Used in combination with other cardiovascular or pain management drugs
Mechanism of Action
Aspirin irreversibly inhibits cyclooxygenase enzymes (COX-1 and COX-2), preventing the conversion of arachidonic acid to prostaglandins and thromboxanes. This reduces pain, inflammation, and fever. The antiplatelet effect is due to inhibition of thromboxane A2 synthesis, decreasing platelet aggregation and promoting cardiovascular protection.
Pharmacological Information
- Chemical Name: 2-Acetoxybenzoic acid
- Molecular Formula: C9H8O4
- Molecular Weight: 180.16 g/mol
- CAS Number: 50-78-2
- Therapeutic Class: Non-Steroidal Anti-Inflammatory Drug (NSAID)
- Pharmacological Class: Analgesic, Antipyretic, Anti-inflammatory
- ATC Code: N02BA01
Physical & Chemical Properties
| Property | Description |
|---|---|
| Appearance | White crystalline powder |
| Solubility | Slightly soluble in water; soluble in ethanol, acetone, and chloroform |
| Melting Point | 135°C – 136°C |
| pH (1% aqueous solution) | 3.5 – 4.5 |
| Storage | Store below 25°C in a dry, ventilated area, protected from light and moisture |
Technical Specifications
| Parameter | Specification |
|---|---|
| Appearance | White crystalline powder |
| Identification | IR and UV analysis positive |
| Assay (Purity) | ≥ 99.0% (HPLC/UV) |
| Loss on Drying | ≤ 0.5% |
| Residue on Ignition | ≤ 0.1% |
| Heavy Metals | ≤ 10 ppm |
| Related Substances | ≤ 0.5% (individual impurity) |
| Bulk Density | 0.40 – 0.55 g/mL |
| Tapped Density | 0.55 – 0.70 g/mL |
Applications
Aspirin Crystal Grade 2080-C API is used in:
- Tablet formulations (immediate and controlled-release)
- Capsule formulations
- Cardiovascular combination therapies
- Pain relief and anti-inflammatory formulations
- Bulk pharmaceutical preparations
Documentation Provided
- Certificate of Analysis (COA)
- Material Safety Data Sheet (MSDS)
- Technical Data Sheet (TDS)
- Method of Analysis (MOA)
- Stability Data (ICH-compliant)
- Regulatory Dossier / DMF (on request)
Packaging & Export Details
- Available Packs: 1 kg | 5 kg | 10 kg | 25 kg HDPE drums with double poly liners
- Labeling: Product name, batch number, manufacturing/expiry dates, storage instructions
- Shelf Life: 36 months under recommended storage conditions
- Export Markets: Africa, Asia, Latin America, Europe, Middle East
