Chloroquine Phosphate

Chloroquine Phosphate is a well-established antimalarial and anti-inflammatory agent used extensively in the treatment and prevention of malaria, particularly Plasmodium vivax, Plasmodium ovale, and Plasmodium malariae infections. In addition to its antimalarial use, Chloroquine Phosphate is also utilized as a disease-modifying antirheumatic drug (DMARD) in the treatment of autoimmune disorders like rheumatoid arthritis and systemic lupus erythematosus (SLE). Its broad pharmacological utility and inclusion on the WHO Model List of Essential Medicines underscores its significance in global public health.

At BluepillExpress, we offer third-party manufacturing services for Chloroquine Phosphate that are driven by strict adherence to WHO-GMP standards, global regulatory compliance, and affordable large-scale production. Whether you’re supplying national healthcare programs, building a generic brand, or distributing to emerging markets, our pharmaceutical manufacturing solutions are designed to support your goals efficiently and reliably.

About BluepillExpress

BluepillExpress is a reputed global pharmaceutical manufacturer, exporter, and third-party partner for a wide array of formulations, therapeutic classes, and market segments. With a footprint in over 25 countries, and facilities certified under WHO-GMP, ISO 9001:2015, and GLP, we are equipped to handle bulk manufacturing of essential medicines and specialty pharmaceuticals.

Our third-party services include:

• End-to-end product manufacturing
• API sourcing and formulation development
• Custom labeling and private branding
• Regulatory document support
• International logistics and export documentation

We work closely with government tenders, NGOs, private healthcare firms, and institutional buyers across Africa, Asia, Middle East, CIS, and Latin America to provide cost-effective, high-quality solutions.

Product Overview: Chloroquine Phosphate

Chloroquine Phosphate is a 4-aminoquinoline compound primarily used as an antimalarial. It interferes with the parasite’s ability to detoxify heme in the red blood cells, ultimately killing the parasite. Aside from malaria, its immunomodulatory properties have made it a useful agent in the treatment of autoimmune diseases.

Key Indications:

• Treatment and prophylaxis of uncomplicated malaria caused by susceptible strains
• Adjunctive therapy in rheumatoid arthritis
• Management of systemic lupus erythematosus
• Off-label use in certain viral infections during outbreak control (subject to government approval)

Chloroquine Phosphate is especially valuable in regions with limited access to newer antimalarials and is frequently included in public health emergency kits and malaria control programs.

Mechanism of Action

Chloroquine acts by:

• Entering red blood cells infected with the Plasmodium parasite
• Accumulating in the parasite’s acidic food vacuole
• Preventing the biocrystallization of heme, a toxic byproduct of hemoglobin digestion
• Causing buildup of free heme, which is toxic to the parasite and leads to its death

Its anti-inflammatory mechanism is believed to involve:

• Inhibition of lysosomal activity
• Reduction in cytokine production (TNF, IL-6)
• Interference with antigen presentation

These diverse actions make Chloroquine Phosphate a multi-indication drug with significant utility across medical disciplines.

Available Dosage Forms

At BluepillExpress, we manufacture Chloroquine Phosphate in a variety of dosage forms and strengths, customized for different treatment settings, age groups, and market requirements:

1. Chloroquine Phosphate Tablets

• 150 mg base (equivalent to 250 mg salt)
• 300 mg base (custom)
• Film-coated or uncoated
• Scored tablets for flexible dosing
• Available in blister or strip packs

2. Chloroquine Phosphate Oral Suspension (on request)

• 50 mg/5 ml or 100 mg/5 ml
• Pediatric-friendly formulations
• Sugar-free and flavored options

3. Chloroquine Phosphate Injection (contract basis)

• 40 mg/ml, 2 ml ampoules
• For severe malaria cases under hospital supervision
• Sterile, pyrogen-free, in amber ampoules

Our dosage forms are manufactured in accordance with international pharmacopeias including USP, BP, IP, and Ph. Eur.

Packaging Formats

We provide international-standard packaging that ensures product stability, compliance, and brand identity.

Tablet Packaging Options:

• Blister packs: PVC/Alu or Alu-Alu
• Strip packaging: Paper or foil
• Mono-cartons with multilingual inserts
• Bulk packaging for institutional supply

Oral Suspension Packaging:

• HDPE bottles with child-resistant caps
• Dosing spoon or oral syringe
• Tamper-evident seals and shrink bands

Injection Packaging:

• Ampoules in 10×2 ml or 5×2 ml trays
• Cartons with labeling as per regulatory needs

Custom packaging designs, color coding by dosage, and barcoding can be included for improved traceability and patient safety.

Manufacturing Infrastructure

BluepillExpress operates WHO-GMP compliant facilities built to handle both solid oral and liquid formulations for domestic and export markets. Our infrastructure includes:

• Dedicated granulation, compression, and coating units
• Fully automated filling and sealing lines
• High-speed blister and strip packing machines
• Sterile zones for parenterals
• In-house water purification and air-handling systems
• Analytical testing and microbiology labs

All equipment is validated and maintained to meet international regulatory and environmental standards, ensuring batch-to-batch consistency, product safety, and regulatory compliance.

Quality Control and Assurance

We follow a multi-tiered quality assurance program to ensure that Chloroquine Phosphate products meet or exceed global expectations for safety, efficacy, and stability.

Quality Assurance Highlights:

• API and excipient identity and purity testing
• In-process quality control (IPQC)
• Finished product analysis including:
  • Assay (active content)
  • Uniformity of weight and content
  • Dissolution and disintegration
  • Microbial limit tests
  • Stability testing under ICH guidelines (Zone I–IVb)

Documentation is maintained in full compliance with Good Laboratory Practices (GLP), ICH Q10, and ISO 9001:2015 standards.

Regulatory Support and Documentation

BluepillExpress provides comprehensive regulatory documentation support to assist clients in product registration and market entry. Our documentation packages include:

• Certificate of Pharmaceutical Product (CoPP)
• Certificate of Analysis (CoA)
• Stability data and shelf-life report
• Manufacturing license and WHO-GMP certification
• Common Technical Document (CTD or eCTD) dossiers
• Batch Manufacturing Records (BMRs)
• Material Safety Data Sheet (MSDS)
• Free Sale Certificate

Our regulatory team ensures timely preparation and delivery of dossiers for both regulated and semi-regulated markets.

Export and Global Supply Chain Support

BluepillExpress has established reliable supply chains and export networks across the globe. We offer:

• Timely delivery via air and sea freight
• Export documentation and customs clearance
• Labeling and artwork customization for destination country
• Track and trace capability for international shipments
• Temperature-controlled shipping (if required)

We support governments and NGOs in malaria control programs, emergency relief, and global tenders, supplying Chloroquine Phosphate in compliance with national and international guidelines.

Target Clients

Our third-party manufacturing of Chloroquine Phosphate caters to:

• Government procurement agencies
• Malaria control initiatives and health NGOs
• Pharmaceutical companies building antimalarial brands
• Hospitals and infectious disease centers
• Private label supplement and drug companies
• Emergency response organizations and disaster aid distributors

We are capable of handling custom formulations, low MOQs, and bulk production to meet varying market needs.

Why Partner with BluepillExpress?

1. WHO-GMP Certified Facilities
   International-grade manufacturing systems that ensure high quality.
2. Wide Range of Formulations and Packaging
   Tablets, suspensions, and injectables with customizable branding options.
3. Complete Regulatory and Technical Support
   CTD dossiers, CoPP, and global compliance documentation provided.
4. Affordable Pricing with Low MOQs
   Making essential medicines accessible and profitable for partners.
5. Global Export Experience
   Proven track record in over 25 countries with full logistic and clearance support.
6. Scalable Production and Fast Turnaround
   Agile systems to handle emergency tenders and scheduled program deliveries.

Conclusion

Chloroquine Phosphate continues to be a vital antimalarial agent and immunomodulatory drug used globally in both preventive and therapeutic applications. Its relevance in endemic regions and its cost-effectiveness make it a cornerstone of public health pharmacotherapy.

BluepillExpress is proud to offer scalable, high-quality third-party manufacturing for Chloroquine Phosphate, ensuring our partners can access the best of pharmaceutical manufacturing—backed by scientific rigor, regulatory compliance, and logistical expertise.