Neomycin & polymixin B sulfates & Bacitracin zinc

The combination of Neomycin, Polymyxin B Sulfates, and Bacitracin Zinc represents a highly effective topical triple antibiotic therapy, widely used for the prevention and treatment of superficial skin infections, minor wounds, cuts, abrasions, and burns. Each component targets a different spectrum of bacteria, ensuring comprehensive protection against gram-positive and gram-negative pathogens.

At BluepillExpress, we specialize in the third-party manufacturing of high-quality topical antibiotic formulations, including this potent triple-antibiotic ointment and cream. Our facilities meet WHO-GMP and ISO standards, and we offer comprehensive services ranging from formulation development and packaging customization to regulatory documentation and global export.

Product Composition

Active Ingredients (per gram of formulation):

• Neomycin Sulfate: Equivalent to 3.5 mg of Neomycin base
• Polymyxin B Sulfate: Equivalent to 5,000 units
• Bacitracin Zinc: 400 units

Formulation Types:

• Topical Ointment (petroleum-based)
• Topical Cream (water-soluble base available upon request)
• Single-use sachets, tubes, or jars

Excipients:

• White soft paraffin, liquid paraffin, emulsifying wax, preservatives, or customized excipients based on client requirements

Therapeutic Uses and Applications

This triple antibiotic formulation is widely indicated for:

• Prevention of infection in minor cuts, scrapes, and burns
• Treatment of superficial bacterial skin infections
• Post-surgical wound dressing support
• Skin ulcers, bedsores, and diabetic wound care (adjunctive)
• Insect bites or rashes at risk of infection
• Dermatological infections of bacterial origin

This product is suitable for over-the-counter (OTC) and prescription-based markets, including clinical, dermatological, first-aid, and consumer healthcare channels.

Mechanism of Action

Each ingredient in the combination plays a unique antimicrobial role:

• Neomycin Sulfate:
  An aminoglycoside that inhibits bacterial protein synthesis by binding to the 30S ribosomal subunit. Effective against gram-negative and some gram-positive bacteria.
• Polymyxin B Sulfate:
  Disrupts the bacterial cell membrane integrity, leading to cell lysis. Highly effective against gram-negative organisms, including Pseudomonas aeruginosa.
• Bacitracin Zinc:
  Interferes with bacterial cell wall synthesis, especially targeting gram-positive bacteria, including Staphylococcus and Streptococcus species.

The synergistic effect provides broad-spectrum, bactericidal activity, ideal for topical infection control.

Formulation and Dosage Forms

At BluepillExpress, we offer:

Topical Ointment

• Neomycin + Polymyxin B + Bacitracin Zinc
• Base: White petrolatum
• Sizes: 5g, 10g, 15g, 20g, 30g, 50g tubes or jars
• Single-dose sachets available on request

Topical Cream

• Optional for clients preferring a non-greasy, easily absorbed base
• Suitable for hot/humid climates or patient preference
• Custom excipient profile for sensitive skin

Packaging Options

We provide full packaging flexibility for local and global markets:

• Aluminum laminated tubes with inner sealing & tamper-evident caps
• HDPE jars with or without outer cartons
• Laminated sachets for institutional or travel use
• Multilingual cartons and labels
• Private label & customized brand identity

All packaging complies with pharmaceutical-grade specifications, including compatibility testing, leakage testing, and stability under shipping conditions.

Why Choose BluepillExpress for Triple Antibiotic Manufacturing?

1. WHO-GMP Certified Manufacturing Facilities

Our production units are equipped with:

• Stainless steel manufacturing vessels with homogenizers
• Cleanroom zones for ointment and cream manufacturing
• Tube and jar filling machines with batch coding
• In-process controls and real-time monitoring systems
• Controlled temperature and humidity environments

We maintain stringent hygiene and environmental standards suitable for dermatological and topical preparations.

2. Custom Formulation Development

Our formulation experts can develop tailored variations of:

• Hydrophilic or lipophilic base (cream vs. ointment)
• Pediatric-friendly formulations (fragrance-free, low-irritant)
• Extended-shelf-life versions with optimized preservatives
• Combination creams with additional antifungals or corticosteroids (on request)
• Oil-free or aloe-based creams for cosmetic markets

We also support pilot batches, stability trials, and lab-scale development for brand innovation.

Quality Control and Testing

BluepillExpress upholds the highest quality assurance protocols for every product:

• Assay of active ingredients (Neomycin, Polymyxin B, Bacitracin)
• Microbial contamination and preservative efficacy
• Homogeneity and consistency of base
• pH, spreadability, and physical appearance testing
• Packaging integrity and compatibility testing
• Stability studies under Zone II & IVa/IVb conditions

All processes are validated and documented as per IP, BP, USP specifications and international standards.

Regulatory and Documentation Support

We provide comprehensive regulatory support, including:

• Certificate of Analysis (CoA)
• Batch Manufacturing Record (BMR)
• Free Sale Certificate (FSC)
• Product Dossier (CTD / ACTD format)
• Stability Data (accelerated and real-time)
• Certificate of Origin (CoO)
• Material Safety Data Sheet (MSDS)
• Method of Analysis (MoA)
• WHO-GMP and ISO 9001:2015 Certification

We assist clients in registering products with health ministries and drug regulatory bodies across Africa, Latin America, Asia, CIS, and the Middle East.

Private Label and Brand Customization Services

Our third-party manufacturing model is built for private label success, offering:

• Customizable brand names and design
• Multilingual labeling for country-specific compliance
• Branded marketing kits, trial packs, and physician samples
• Eco-friendly or recyclable packaging options
• Regulatory artwork review and proofing
• Serialization and tamper-evidence support

Whether you’re building a new OTC range or supplying tenders, we support end-to-end brand development.

Export and Global Supply Chain

We are export-ready with a proven track record of international pharmaceutical shipments to over 35 countries:

• Air and sea freight coordination
• Logistics support and shipping documentation
• Pre-shipment inspection (SGS, Bureau Veritas, Intertek)
• Assistance with customs clearance and MoH approvals
• Temperature-controlled storage and supply chain on demand

We handle large-volume orders, hospital supply, and NGO procurement with speed, safety, and compliance.

Manufacturing Process and Client Collaboration

Our third-party manufacturing process includes:

1. Initial Consultation & Requirement Finalization
   • Product specs, packaging, documentation needs
2. Quotation & Agreement Signing
   • MOQs, pricing, and commercial terms confirmed
3. Sample Submission (if required)
   • Product prototype sent for client testing and feedback
4. Artwork and Packaging Approval
   • Brand identity, labels, inserts, and language finalized
5. Batch Manufacturing & QA Testing
   • GMP-compliant batch production with CoA
6. Dispatch & Delivery
   • Final shipment with regulatory and export documentation

Lead Time: 30–45 business days from artwork and payment confirmation

Client Profiles and Market Segments

BluepillExpress offers tailored manufacturing services to:

• Generic pharmaceutical companies
• OTC personal care brands
• Dermatology and skincare distributors
• Hospitals and institutional pharmacies
• Aid organizations and health NGOs
• National and regional tender suppliers

We support both low MOQ private-label launches and bulk production for government or export projects.

Key Advantages of Partnering with BluepillExpress

• WHO-GMP certified infrastructure
• Comprehensive product customization
• Affordable and scalable manufacturing model
• Expertise in semi-solid formulations
• Reliable regulatory and technical support
• End-to-end private label solutions
• International shipping and distribution management
• On-time delivery and dedicated client support

Conclusion

The combination of Neomycin, Polymyxin B Sulfates, and Bacitracin Zinc remains a trusted and effective treatment for topical bacterial infections, offering reliable protection and healing across all age groups and clinical settings.

At BluepillExpress, we provide turnkey manufacturing solutions for this essential medicine—backed by modern technology, strict quality control, international documentation, and client-focused customization. Whether you’re launching a retail skincare brand, fulfilling a hospital supply tender, or expanding into global pharmaceutical markets, we deliver solutions tailored to your business goals.