IndiaMart
FIEO
Clobetasol Propionate & Neomycin Sulfate is a powerful dermatological combination used for treating a variety of inflammatory skin conditions complicated by secondary bacterial infections. Clobetasol Propionate, a potent corticosteroid, reduces inflammation, itching, and redness, while Neomycin Sulfate, an aminoglycoside antibiotic, combats skin infections caused by susceptible bacteria. Together, they offer a synergistic effect that effectively relieves symptoms and prevents complications in chronic dermatoses, eczema, psoriasis, and infected dermatitis.
At BluepillExpress, we provide WHO-GMP and ISO 9001:2015 certified third-party manufacturing services for Clobetasol Propionate & Neomycin Sulfate formulations. Our advanced dermatological production infrastructure, experienced formulation teams, and stringent quality control protocols ensure high-efficacy, market-ready products tailored for domestic and global markets.
What is Clobetasol Propionate & Neomycin Sulfate?
Clobetasol Propionate is a super-high-potency corticosteroid that works by inhibiting multiple inflammatory cytokines, thereby reducing redness, swelling, and skin irritation.
Neomycin Sulfate is a broad-spectrum topical antibiotic that acts by inhibiting bacterial protein synthesis, making it effective against a range of gram-positive and gram-negative bacteria.
Therapeutic Class: Topical corticosteroid + antibacterial combination
Mechanism of Action:
- Clobetasol Propionate binds to cytoplasmic glucocorticoid receptors and modifies the inflammatory response.
- Neomycin Sulfate interferes with bacterial protein synthesis by binding to the 30S ribosomal subunit.
Route of Administration: Topical
Therapeutic Indications
The Clobetasol + Neomycin combination is primarily indicated in corticosteroid-responsive dermatoses complicated by secondary bacterial infections.
Common Conditions Treated:
- Infected eczema and dermatitis
- Psoriasis with secondary infection
- Lichen planus
- Seborrheic dermatitis
- Contact dermatitis (irritant or allergic)
- Infected insect bites
- Pruritic skin conditions
- Atopic dermatitis
- Intertrigo with infection
- Chronic skin conditions aggravated by bacteria
The combination is widely used in dermatology, general medicine, and pediatric practice due to its dual-action therapeutic benefits.
Why Choose BluepillExpress?
At BluepillExpress, we offer world-class third-party manufacturing services for topical preparations, catering to multinational brands, private labels, hospital supply chains, and NGOs.
Our Key Strengths:
- WHO-GMP & ISO certified manufacturing plants
- Specialization in dermatological ointments, creams, and lotions
- Dedicated production zones for corticosteroid and antibiotic products
- State-of-the-art homogenizers and filling lines
- IP/BP/USP/EP compliant formulations
- Customization in formulation type, strength, and packaging
- Private label and OEM solutions with multilingual support
- Full regulatory documentation and fast export processing
We ensure consistency, efficacy, and compliance in every batch delivered to our partners.
Available Formulations and Strengths
We manufacture Clobetasol Propionate & Neomycin Sulfate in various topical dosage forms for prescription and over-the-counter (OTC) markets.
Common Formulations:
- Clobetasol Propionate 0.05% w/w + Neomycin Sulfate 0.5% w/w Cream
- Clobetasol Propionate 0.05% w/w + Neomycin Sulfate 0.5% w/w Ointment
- Clobetasol Propionate 0.05% w/w + Neomycin Sulfate 0.5% w/w Lotion (available on request)
- With or without excipients like glycerin, aloe vera, or urea based on client preference
We also provide alcohol-free, pediatric, and fragrance-free variations suitable for specialized patient groups.
Product Composition
Each formulation is developed using high-purity APIs, dermatologically safe excipients, and emollients to ensure optimal efficacy and skin tolerance.
Example Composition – Cream Base:
- Active Ingredients:
- Clobetasol Propionate IP/BP/USP 0.05% w/w
- Neomycin Sulfate IP/BP/USP equivalent to 0.5% w/w
- Base Ingredients:
- White soft paraffin, cetostearyl alcohol, propylene glycol, light liquid paraffin, purified water, emulsifying wax
- Preservatives (if required): Methylparaben, Propylparaben
All ingredients are selected to promote stability, smooth texture, and rapid skin absorption.
Manufacturing Process
We follow a validated and quality-assured process for all topical formulations, ensuring consistency in texture, spreadability, and drug release.
Key Manufacturing Steps:
- Raw Material Verification & Weighing
- Aqueous and Oil Phase Preparation
- Emulsification under vacuum homogenization
- Cooling and homogenizing to ensure uniformity
- Addition of actives and preservatives under controlled conditions
- Filling into tubes or containers using automatic filling lines
- Batch coding, labeling, and packaging
Our manufacturing zones are classified for semi-solid and hormone-based product safety, ensuring contamination-free production.
Quality Control and Testing
At BluepillExpress, we maintain strict in-process and finished-product quality testing, backed by modern instrumentation and experienced QA professionals.
QC Parameters Include:
- Assay of active ingredients
- pH and viscosity
- Microbial limit and preservative efficacy
- Homogeneity and texture analysis
- Water content and spreadability
- Stability testing (ICH guidelines for temperature and humidity)
- Packaging integrity and tube compatibility tests
Each batch is released only after QC, QA, and documentation verification, and is supported by a Certificate of Analysis (COA).
Packaging Options
We offer flexible, brand-oriented packaging options to meet your market and customer demands.
Packaging Formats:
- Aluminum tubes (5 g, 10 g, 15 g, 20 g, 30 g)
- Laminated tubes (Lami Tubes) with tamper-evident seals
- Plastic tubes with nozzle caps for precise application
- Carton box packaging with or without patient leaflet
- Multilingual printing and custom foil/label design
We support full private label development, including logo, color, font, design layouts, and regulatory compliance information.
Regulatory Documentation and Compliance
We provide a complete set of regulatory documents to help you register, market, and export Clobetasol + Neomycin formulations worldwide.
Available Documentation:
- WHO-GMP Certificate
- Certificate of Pharmaceutical Product (COPP)
- Certificate of Analysis (COA)
- Stability Data (real-time and accelerated)
- Free Sale Certificate (FSC)
- Product Dossier (CTD/ACTD format)
- Batch Manufacturing Records (BMR)
- Master Formula Records (MFR)
- Method of Analysis (MOA)
- Safety Data Sheet (SDS)
- Product Inserts and Label Mockups
We support regulatory filings in semi-regulated and regulated markets, including tender submissions and MOH approvals.
Export and Global Supply Chain Capabilities
BluepillExpress exports Clobetasol Propionate & Neomycin Sulfate formulations to over 40 countries, ensuring timely and safe product delivery through well-managed supply chains.
Major Export Regions:
- Africa: Nigeria, Kenya, Ghana, Ethiopia, Zambia
- Middle East: Iraq, Yemen, UAE, Saudi Arabia
- Asia-Pacific: Philippines, Vietnam, Myanmar, Sri Lanka
- CIS Countries: Uzbekistan, Georgia, Armenia
- Latin America & Caribbean: Peru, Bolivia, Dominican Republic
- Island Nations: Papua New Guinea, Maldives
We assist with all shipping documentation, including bill of lading, MSDS, COA, and insurance.
Ideal Clients for Clobetasol + Neomycin Manufacturing
This product is ideal for companies and institutions such as:
- Dermatology product marketers
- Government health departments and NGOs
- OTC and prescription drug retailers
- Hospital and clinical procurement agencies
- Exporters and international tender participants
- E-commerce or telemedicine platforms
- Private label dermatology brands
Why Partner with BluepillExpress?
- WHO-GMP Certified and export-ready production
- Decades of experience in topical formulation manufacturing
- Customizable strengths, bases, and pack sizes
- Regulatory and dossier support for global registrations
- Low MOQ with rapid production timelines
- Full private labeling and brand support
- Compliant with IP/BP/USP/EP standards
At BluepillExpress, we deliver high-quality topical formulations that help brands grow, patients recover, and health systems succeed.
