Levodopa & Carbidopa

Levodopa & Carbidopa is a clinically significant combination therapy used primarily for the treatment of Parkinson’s disease and Parkinsonism-related disorders. This medication acts by replenishing dopamine in the brain—a critical neurotransmitter responsible for movement control—making it a cornerstone of modern Parkinson’s therapy.

At BluepillExpress, we offer third-party manufacturing of Levodopa & Carbidopa with GMP-compliant processes, high-quality raw materials, and customizable branding solutions. Our state-of-the-art infrastructure, regulatory expertise, and commitment to therapeutic excellence make us a global leader in the formulation, production, and supply of combination drugs for neurological and movement disorders.

Understanding Levodopa & Carbidopa

Levodopa is a dopamine precursor that crosses the blood-brain barrier, where it is converted into dopamine, helping alleviate motor symptoms of Parkinson’s disease. However, when administered alone, a significant portion of Levodopa is metabolized peripherally before reaching the brain. Carbidopa acts as a peripheral dopa-decarboxylase inhibitor, preventing the premature conversion of Levodopa, allowing more of it to reach the brain and improving its efficacy while reducing side effects such as nausea and vomiting.

Clinical Indications:

• Idiopathic Parkinson’s disease
• Post-encephalitic Parkinsonism
• Symptomatic Parkinsonism following carbon monoxide or manganese intoxication
• Restless leg syndrome (off-label)
• Dopa-responsive dystonia (off-label)

This combination improves bradykinesia, tremors, rigidity, and muscle stiffness, enhancing quality of life and mobility for patients.

Why Choose BluepillExpress for Levodopa & Carbidopa Manufacturing?

BluepillExpress brings technical expertise, regulatory strength, and flexible third-party manufacturing capabilities to the table. As a WHO-GMP certified, ISO 9001:2015 accredited pharmaceutical manufacturing company, we offer our clients:

• Customizable formulations with various strength combinations
• Private label and white label manufacturing
• Global export and compliance documentation
• End-to-end service from API sourcing to final dispatch
• Scalable production with small and large batch capabilities
• Quick turnaround time with strict adherence to timelines
• Dedicated regulatory and technical support team

We work with global partners including pharmaceutical marketing firms, hospitals, public health agencies, and institutional buyers, ensuring efficient market launch and compliance.

Formulations Offered

We provide multiple dosage strengths and customized formulations for different clinical and market needs. Our production is aligned with international pharmacopeial standards (USP, BP, IP, EP).

1. Levodopa 100 mg + Carbidopa 25 mg Tablets

• Standard immediate-release tablet
• Suitable for mild to moderate Parkinson’s disease
• Packaging: 10×10 alu-alu or blister packs
• Shelf Life: 24–36 months

2. Levodopa 250 mg + Carbidopa 25 mg Tablets

• Preferred strength for moderate to severe cases
• Available in scored tablet format
• Packaging: Strip or blister format
• Storage: Ambient conditions

3. Levodopa + Carbidopa Controlled Release Tablets

• Strengths: 200 mg + 50 mg
• Designed to maintain steady plasma concentration
• Benefits: Reduces “off” episodes, improves motor fluctuations
• Dosage Form: Film-coated sustained-release tablets

4. Orally Disintegrating Tablets (ODTs)

• For patients with swallowing difficulties
• Flavored and fast-melting
• Available on custom order

5. Combination Variants

• Levodopa + Carbidopa + Entacapone (on request)
• Other tailored ratios per market demand

Our production is designed to serve neurology departments, clinics, and home-care patients, and supports both institutional supply and retail distribution.

Manufacturing Capabilities

Our advanced pharmaceutical manufacturing plants are equipped with cutting-edge machinery, designed to maintain product quality and regulatory compliance across all stages of production.

Facility Highlights:

• Automated granulation, drying, blending, and compression lines
• Dedicated oral solid dosage areas with strict cross-contamination controls
• In-house laboratory for analytical and microbiological testing
• Packaging machines for strip, alu-alu, and bottle formats
• HVAC-controlled cleanrooms (ISO Class 8 or better)
• Water purification systems (RO and WFI compliant)
• Capacity for both small and high-volume batches

We follow validated SOPs, maintain Batch Manufacturing Records (BMR), and employ trained personnel to ensure consistency, purity, and accuracy.

Quality Assurance and Quality Control (QA/QC)

At BluepillExpress, quality is not just a promise—it is a system. Every batch of Levodopa & Carbidopa is subjected to rigorous quality testing protocols at each critical point in the manufacturing cycle.

QA/QC Testing Includes:

• Assay and content uniformity
• Dissolution and disintegration
• Microbial contamination testing
• Heavy metals and residual solvent analysis
• Accelerated and long-term stability studies (ICH guidelines)
• Packaging integrity and label verification
• Compliance with USP/BP/IP/EP specifications

We provide the following standard documents with each batch:

• Certificate of Analysis (COA)
• Material Safety Data Sheet (MSDS)
• Certificate of Origin (COO)
• Stability Data and Validation Reports
• Method of Analysis (MOA)
• Product Specification File (PSF)

Packaging & Custom Branding

Packaging plays a vital role in patient compliance, product shelf life, and market success. BluepillExpress offers tailor-made packaging options for both export and domestic markets.

Packaging Options:

• Blister packs (PVC, PVDC, alu-alu)
• Strip packs (paper/aluminum foil)
• Bottled tablets with desiccant and moisture barrier
• Outer cartons with brand-specific designs
• Patient information leaflets (PIL)
• Serialization, barcoding, holograms, and anti-counterfeit solutions

We help clients with graphic design, multilingual labeling, and country-specific regulatory label templates.

Regulatory Support

Our regulatory affairs team offers full support for registration, licensing, and compliance in both regulated and semi-regulated markets.

We provide:

• WHO-GMP Certificate
• Certificate of Pharmaceutical Product (CoPP)
• Free Sale Certificate
• CTD/ACTD/eCTD Dossiers
• Site Master File
• Stability and BE/Bioequivalence study support (as applicable)
• Audit assistance and prequalification documentation

We ensure seamless coordination with health authorities in Africa, Asia, CIS, Middle East, and Latin America, assisting in fast-track registration.

Private Label & White Label Solutions

Whether you’re a startup entering the neurology segment or an established brand seeking expansion, our private and white label solutions offer complete support from product selection to market launch.

Our Services Include:

• Custom brand name and packaging design
• Confidentiality agreements (NDAs)
• Low MOQ for initial batch trials
• Custom promotional material (on request)
• Dedicated account manager for project oversight
• Fast turnaround on development and dispatch

Our white-label inventory is also available for urgent orders, helping clients save time and capture market opportunities.

Global Export & Logistics

As an established global exporter, BluepillExpress serves clients across more than 30 countries, including markets in:

• Africa (Nigeria, Ghana, Kenya, Ethiopia)
• Middle East (UAE, Iraq, Jordan, Yemen)
• CIS (Uzbekistan, Armenia, Tajikistan)
• Southeast Asia (Vietnam, Cambodia, Philippines)
• Latin America (Bolivia, Paraguay, Dominican Republic)

We manage:

• International freight (sea/air/courier)
• EXW, FOB, CIF, DDP shipping terms
• Cold chain logistics (if required)
• Export clearance and documentation
• Track-and-trace enabled shipping
• Warehousing and bonded zone access (on request)

Minimum Order Quantities (MOQ)

BluepillExpress supports clients of all sizes with flexible MOQs, such as:

• Pilot batches for testing and registration
• Medium batches for hospitals or local tenders
• Large production runs for national or multi-country supply
• Institutional contracts with staggered delivery options

MOQ varies by dosage form, regulatory requirement, and market destination.

Client Testimonials

“BluepillExpress was instrumental in helping us launch our neurology division. Their Levodopa & Carbidopa tablets were of top-tier quality and fully compliant with our country’s requirements.”
— Pharmaceutical Company, East Africa

“Their CTD dossier for Levodopa & Carbidopa passed regulatory review with minimal queries. Great packaging, prompt shipment, and transparent process.”
— Regulatory Officer, Southeast Asia

“We needed a dependable private label manufacturer for Parkinson’s medications. BluepillExpress exceeded expectations with their manufacturing precision and branding support.”
— Hospital Procurement Manager, Middle East

Conclusion

Levodopa & Carbidopa remains one of the most effective and widely prescribed medications for managing Parkinson’s disease and related disorders. As the demand for neurological therapies rises worldwide, the need for a reliable, high-quality manufacturing partner is greater than ever.

At BluepillExpress, we bring together science, compliance, and scalability to help our partners deliver therapeutic excellence. Whether you’re looking to expand your neurology portfolio, enter new international markets, or serve public health needs, we’re here to help you succeed.