Metoclopramide

Metoclopramide is a well-established medication used in the treatment of gastrointestinal motility disorders and nausea-related conditions. Recognized by the World Health Organization (WHO) as an essential medicine, Metoclopramide plays a vital role in both outpatient and inpatient care for indications such as gastroparesis, reflux disease, and chemotherapy-induced nausea. With widespread clinical applications and global demand, the need for high-quality, GMP-compliant Metoclopramide manufacturing has never been greater.

At BluepillExpress, we offer specialized third-party manufacturing services for Metoclopramide, ensuring pharmaceutical partners across the globe receive safe, effective, and regulatory-compliant products. Backed by WHO-GMP certifications, robust infrastructure, and a focus on quality and scalability, BluepillExpress is your trusted manufacturer for Metoclopramide in oral and injectable forms.

About BluepillExpress

BluepillExpress is a global pharmaceutical manufacturing company with a strong foothold in contract and third-party manufacturing of essential medicines. With a client base across Asia, Africa, the Middle East, CIS, and Latin America, we support private brands, government health programs, and international non-governmental organizations.

Key Capabilities:

• WHO-GMP and ISO 9001:2015 certified facilities
• Extensive portfolio of APIs and finished formulations
• End-to-end support: formulation, manufacturing, packaging, documentation, and logistics
• Customizable dosage forms, packaging, and private-label solutions
• Proven expertise in regulatory submissions and international compliance

Our approach combines modern pharmaceutical practices with efficient production timelines to meet the evolving needs of our partners.

Product Overview: Metoclopramide

Metoclopramide is a dopamine D2 receptor antagonist with prokinetic and antiemetic properties. It enhances gastrointestinal motility and is commonly prescribed for conditions associated with delayed gastric emptying or nausea and vomiting.

Pharmacological Class: Antiemetic, Gastroprokinetic Agent
Mechanism of Action: Blocks dopamine receptors in the chemoreceptor trigger zone and increases the tone and amplitude of gastric contractions while relaxing the pyloric sphincter and duodenal bulb

Therapeutic Uses:

• Nausea and vomiting (including chemotherapy and post-operative)
• Gastroesophageal reflux disease (GERD)
• Diabetic gastroparesis
• Functional dyspepsia
• Pre-radiological procedures involving the GI tract
• Prevention of nausea during anesthesia

Available Dosage Forms and Strengths

BluepillExpress offers Metoclopramide in various forms to address both chronic and acute indications:

• Metoclopramide Hydrochloride 10 mg Tablets
• Metoclopramide Hydrochloride 5 mg/5 ml Oral Solution/Syrup
• Metoclopramide Injection 5 mg/ml (2 ml ampoules)
• Metoclopramide 10 mg Dispersible or Orally Disintegrating Tablets (available upon request)
• Modified-release tablets for extended prokinetic effect (on request)

All formulations are manufactured using pharmacopoeial-grade raw materials compliant with IP, BP, or USP standards.

Clinical Advantages of Metoclopramide

• Dual action: Combines antiemetic and prokinetic properties
• Rapid onset of relief in both acute and chronic cases
• Effective for short-term management of nausea and gastroparesis
• Available in both oral and parenteral routes for varied clinical settings
• Safe for use in children and adults, under medical supervision
• Included in the WHO Essential Medicines List

Manufacturing Infrastructure at BluepillExpress

BluepillExpress maintains state-of-the-art manufacturing facilities for both oral and injectable pharmaceuticals. Our infrastructure supports scalable production of Metoclopramide formulations with precision, safety, and consistency.

Core Manufacturing Capabilities:

• Automated tablet compression and coating units
• Liquid filling lines for oral syrups
• Ampoule washing, filling, and sealing machines for injectables
• Cleanroom facilities adhering to Class 100,000 environments
• HEPA-filtered air handling units with HVAC systems
• Compliance with GMP standards for sterile and non-sterile products

We have a dedicated line for antimotility and gastrointestinal drugs, ensuring minimal cross-contamination and efficient process validation.

Quality Assurance & Control

At BluepillExpress, quality is integrated into every step of the production process. We adhere to strict QA/QC protocols that meet international benchmarks.

Quality Measures Include:

• Analytical testing of raw materials and excipients
• In-process quality control (IPQC) including disintegration, hardness, and uniformity checks
• Finished product testing: assay, dissolution, pH, microbial limits
• Stability studies under accelerated and long-term ICH conditions
• Impurity profiling and microbial load assessments
• Certificate of Analysis (CoA) and Batch Manufacturing Records (BMR) for every batch

We ensure complete traceability and transparency from procurement to dispatch.

Shelf Life and Storage Recommendations

• Tablets/Syrup: 24 to 36 months depending on packaging and market regulations
• Injections: 24 months in light-protective ampoules
• Storage Conditions: Below 25–30°C; avoid direct sunlight and excess humidity
• Stability-Compliant Packaging: Designed for tropical, humid climates in Asia and Africa

Our packaging materials are chosen to preserve product stability in the most challenging environmental conditions.

Packaging and Private Label Options

BluepillExpress offers customized packaging solutions for both retail and institutional use:

Tablets:

• Blister Packs: 10×10, 10×15, 1×10
• Alu-Alu and Alu-PVC configurations

Syrup:

• Bottles: 60 ml, 100 ml, 120 ml (PET or Amber Glass)
• Child-proof caps and calibrated dosing spoons/cups

Injectables:

• 2 ml ampoules (box of 5 or 10)
• Printed ampoules with colored snap-off rings
• Flip-off seal and tamper-evident packaging

Labeling Services Include:

• Multilingual packs and inserts
• Barcoding and serialization support
• Country-specific regulatory text and warnings
• Support for OTC, Rx, and hospital-use packaging

Private label branding is available for all dosage forms.

Regulatory Support and Documentation

We provide comprehensive support for drug registration and regulatory submission in various global markets.

Documents Provided:

• WHO-GMP Certificate
• Certificate of Pharmaceutical Product (COPP)
• Free Sale Certificate
• Dossiers in CTD/ACTD format
• CoA and MSDS
• Stability data and packaging specifications
• Product Leaflets and Artwork Templates

Our regulatory affairs team assists in filing, follow-ups, and variation responses, ensuring smooth and efficient approvals.

Export & Logistics Expertise

BluepillExpress offers reliable and compliant export logistics for international delivery of Metoclopramide formulations.

Key Export Services:

• Air, sea, and land freight shipping
• Temperature-controlled packaging (for injectables)
• Pre-shipment inspections (SGS, Bureau Veritas, Intertek)
• Consolidated shipping for multi-product orders
• Export documentation: Invoice, Packing List, CoA, COO, and more

We currently supply to government health departments, institutional buyers, humanitarian organizations, and private distributors in over 30 countries.

Target Market and Applications

Our Metoclopramide manufacturing is ideal for:

• Government and public sector healthcare procurement
• Hospitals and clinics for inpatient and emergency use
• NGOs and international medical supply programs
• Private pharmaceutical companies launching branded generics
• Pharmacies and e-commerce medicine platforms

Whether for tender participation or branded market entry, we support our clients with a complete turnkey solution.

Why Choose BluepillExpress for Metoclopramide Manufacturing?

• WHO-GMP certified facilities and global export capabilities
• End-to-end third-party manufacturing solutions
• Flexible dosage forms, packaging, and private labeling
• Full regulatory support with CTD/ACTD dossiers
• Dedicated infrastructure for antiemetic and GI drugs
• Competitive pricing and timely delivery
• Experience across 30+ regulated and semi-regulated markets

Our commitment is to provide not only a product but a complete pharmaceutical partnership, ensuring consistent quality, transparency, and mutual growth.

Conclusion

As the demand for effective, fast-acting antiemetic and prokinetic agents continues to rise, Metoclopramide remains a cornerstone medication in healthcare systems worldwide. At BluepillExpress, we are proud to manufacture and supply Metoclopramide to meet the needs of patients, healthcare providers, and institutions across the globe.

With a focus on quality, compliance, affordability, and customization, BluepillExpress delivers trusted third-party manufacturing solutions for Metoclopramide, supporting health outcomes while empowering our partners’ business success.