Cefpodoxime Proxetil

The increasing prevalence of bacterial infections and rising antimicrobial resistance have led to the growing demand for safe, effective, and broad-spectrum oral antibiotics. Among the most trusted options in this category is Cefpodoxime Proxetil, a third-generation cephalosporin antibiotic widely prescribed for its broad antimicrobial coverage, excellent tolerability, and favorable pharmacokinetic profile.

At BluepillExpress, we specialize in third-party and contract manufacturing of high-quality Cefpodoxime Proxetil formulations for global pharmaceutical partners. With a WHO-GMP certified infrastructure, advanced R&D, and comprehensive regulatory support, we deliver effective, stable, and market-ready antibiotic products that meet international compliance and therapeutic efficacy standards.

About BluepillExpress

BluepillExpress is a globally recognized pharmaceutical manufacturer and third-party contract partner, providing comprehensive solutions for manufacturing, packaging, labeling, and exporting pharmaceutical and nutraceutical products. Headquartered in India, we operate with a vision to offer cost-effective, innovative, and high-quality medicines to clients across 30+ countries, including regions in Asia, Africa, Latin America, the Middle East, and the CIS.

With internationally certified manufacturing facilities (WHO-GMP, ISO 9001:2015, FSSAI), BluepillExpress is fully equipped to produce high-quality antibiotic formulations like Cefpodoxime Proxetil, available in multiple strengths and dosage forms.

Product Overview: Cefpodoxime Proxetil

Cefpodoxime Proxetil is an oral, third-generation cephalosporin antibiotic that exhibits strong bactericidal activity against a wide range of Gram-positive and Gram-negative bacteria. It is a prodrug that, upon ingestion, is hydrolyzed in the gastrointestinal tract to release the active compound, Cefpodoxime, which exerts its antibacterial effects by inhibiting bacterial cell wall synthesis.

Therapeutic Classification:

Third-generation cephalosporin (Beta-lactam antibiotic)

Mechanism of Action

Cefpodoxime binds to penicillin-binding proteins (PBPs) located inside the bacterial cell wall. This binding inhibits the final transpeptidation step of peptidoglycan synthesis in bacterial cell walls, ultimately leading to cell lysis and death. Its bactericidal activity and resistance to many beta-lactamases make it an effective choice for both uncomplicated and complicated bacterial infections.

Available Strengths and Dosage Forms

At BluepillExpress, we offer Cefpodoxime Proxetil in various dosage strengths and formats, customizable according to the client’s market demand:

• Tablets: 100 mg, 200 mg
• Dry Syrup (for pediatric use): Cefpodoxime Proxetil 50 mg/5 ml (reconstitutable powder)
• Dispersible Tablets: 100 mg, 200 mg
• Capsules (optional based on custom development)

All dosage forms are manufactured using high-purity active ingredients, stable excipients, and pharmaceutical-grade packaging to ensure optimal bioavailability, safety, and patient compliance.

Therapeutic Indications

Cefpodoxime Proxetil is widely prescribed for treating mild to moderate infections, including:

• Upper respiratory tract infections (e.g., pharyngitis, tonsillitis)
• Lower respiratory tract infections (e.g., bronchitis, mild pneumonia)
• Urinary tract infections (e.g., cystitis, urethritis)
• Skin and soft tissue infections
• Otitis media (especially in pediatric patients)
• Sinusitis
• Gonorrhea (uncomplicated cases)
• Community-acquired pneumonia
• Typhoid and enteric fever (as part of combination therapy)

Pharmacokinetics

• Bioavailability: Approximately 50% after oral administration
• Peak Plasma Time: 2 to 3 hours post-administration
• Elimination Half-Life: 2 to 3 hours
• Excretion: Primarily via urine
• Food Effect: Absorption enhanced with food intake

Key Advantages of Cefpodoxime Proxetil

• Broad-spectrum antibacterial coverage
• Suitable for both adults and children
• Beta-lactamase stable antibiotic
• Excellent gastrointestinal tolerance
• Convenient twice-daily dosing
• High compliance rate due to minimal side effects
• Safe for long-term outpatient treatment

Manufacturing Excellence at BluepillExpress

At BluepillExpress, the production of Cefpodoxime Proxetil adheres strictly to Good Manufacturing Practices (GMP) and international regulatory norms. Our advanced manufacturing facilities include:

• Dedicated Antibiotic Production Zones: Segregated areas for beta-lactam and cephalosporin products to avoid cross-contamination
• Cleanroom Environments: ISO Class 7 and Class 8 clean areas for granulation, blending, compression, and packaging
• Modern Equipment: Fluid bed dryers, rapid mixers, tablet compression machines, automatic syrup filling and sealing machines
• In-house QC Laboratories: Equipped with HPLC, UV Spectrophotometers, Dissolution Testers, and Stability Chambers

Packaging & Labeling Options

We offer customizable packaging solutions tailored to the specific regulatory requirements and branding needs of our partners:

• Tablets/Capsules:
  • Blister packs (Alu-Alu, Alu-PVC)
  • Strip packs
  • HDPE bottles for bulk packaging
• Dry Syrup:
  • Amber or white HDPE bottles with child-resistant caps
  • Reconstitution instructions and calibrated measuring spoons
  • Outer monocartons with multilingual labels
• Labeling Support:
  • Custom design and printing services
  • Regulatory-compliant label content
  • Tamper-evident packaging options
  • QR code/barcode traceability (optional)

Quality Control and Assurance

BluepillExpress places quality at the core of every manufacturing step. Our QA/QC protocols ensure the highest safety, efficacy, and consistency across batches:

• Raw Material Testing: Identity, potency, microbial limits
• In-process Quality Control: Granulation parameters, weight variation, uniformity of content, dissolution
• Finished Product Testing: Assay, microbial contamination, stability, appearance, packaging integrity
• Documentation: Certificate of Analysis (CoA), Batch Manufacturing Records (BMR), Standard Operating Procedures (SOPs)

All testing is conducted as per Pharmacopeial Standards (IP, USP, BP) using validated analytical methods.

Stability and Shelf Life

Our Cefpodoxime Proxetil formulations undergo accelerated and real-time stability testing to ensure efficacy throughout the product lifecycle:

• Dry Syrup Shelf Life: 18–24 months (unreconstituted)
• Tablets/Capsules Shelf Life: 24–36 months
• Packaging Compatibility Studies: Conducted to maintain chemical and microbiological stability

Regulatory and Export Support

As a global supplier, BluepillExpress provides full regulatory assistance and export documentation, including:

• Certificate of Pharmaceutical Product (COPP)
• Certificate of Analysis (CoA)
• GMP Certificate
• Stability Data
• CTD/ACTD Dossiers for product registration
• Free Sale Certificate
• Material Safety Data Sheet (MSDS)
• WHO Prequalification Documentation (if required)

Private Label & Customization Services

We offer comprehensive private labeling services and tailored manufacturing solutions:

• Custom formulation support
• Unique flavoring for pediatric syrups
• Brand identity creation (logo, label, leaflet)
• Low minimum order quantities for startups
• Full confidentiality and IP protection

Logistics and Export Capabilities

Our logistics team ensures prompt, secure, and compliant global delivery:

• Bulk and finished packaging export-ready
• Air, sea, and courier freight support
• Multilingual documentation and labeling
• Cold chain management (if required)
• Coordination with freight forwarders and customs agents

Target Partners and Markets

• Branded generic pharmaceutical companies
• Hospital procurement groups
• Tender suppliers and institutional buyers
• Pediatric formulation marketers
• Distributors in Africa, Asia, Middle East, and Latin America
• Government and NGO procurement channels

Why Partner with BluepillExpress?

• WHO-GMP, ISO, and FSSAI certified facilities
• Robust manufacturing capacity for oral antibiotics
• Regulatory expertise for global markets
• Flexible production volumes and batch sizes
• Consistent product quality and documentation
• Full-spectrum service—from formulation to packaging and export
• Trusted by clients in over 30 countries

Conclusion

The growing demand for safe, broad-spectrum oral antibiotics like Cefpodoxime Proxetil offers tremendous opportunities for global pharmaceutical businesses. At BluepillExpress, we stand as a reliable partner for the third-party manufacturing of this essential antibiotic—combining scientific precision, international compliance, and tailored services to ensure our clients deliver high-quality, effective medications to their target markets.

With our experience, regulatory readiness, and commitment to excellence, we are ready to manufacture Cefpodoxime Proxetil products that meet global expectations and healthcare needs.