Cefoperazone & Sulbactam

As antibiotic resistance continues to pose a significant challenge to global healthcare, the need for powerful and broad-spectrum antimicrobial agents has never been more critical. Among the most effective combinations in the fight against multidrug-resistant infections is Cefoperazone and Sulbactam. This synergistic beta-lactam/beta-lactamase inhibitor combination has demonstrated high efficacy against a wide range of gram-positive and gram-negative pathogens.

BluepillExpress is proud to offer third-party manufacturing of Cefoperazone & Sulbactam injections, adhering to the highest standards of pharmaceutical manufacturing, quality control, and regulatory compliance. With global certifications and robust infrastructure, we support healthcare providers, distributors, and pharmaceutical companies in launching or expanding their portfolio of injectable antibiotics.

About BluepillExpress

BluepillExpress is an internationally recognized pharmaceutical third-party manufacturer and global exporter, committed to delivering quality-focused, evidence-based pharmaceutical products across Asia, Africa, the Middle East, CIS countries, and Latin America.

With WHO-GMP, ISO 9001:2015, and EU-GMP (select units) certifications, we cater to a broad spectrum of clients, ranging from multinational companies to hospital chains, government agencies, and private label distributors. We provide comprehensive third-party manufacturing services—from formulation development and packaging to regulatory documentation and international shipping.

Product Overview: Cefoperazone & Sulbactam Injection

Cefoperazone and Sulbactam is a combination antibiotic that provides broad-spectrum coverage for the treatment of serious bacterial infections. Cefoperazone, a third-generation cephalosporin, is active against a wide range of gram-negative and some gram-positive bacteria. Sulbactam, a beta-lactamase inhibitor, extends Cefoperazone’s activity by inhibiting bacterial enzymes that would otherwise degrade the antibiotic.

This combination is commonly used to treat infections such as:

• Lower respiratory tract infections
• Urinary tract infections
• Intra-abdominal infections
• Septicemia
• Skin and soft tissue infections
• Gynecological infections
• Bone and joint infections

Mechanism of Action

• Cefoperazone interferes with bacterial cell wall synthesis, leading to lysis and death of the organism.
• Sulbactam binds irreversibly to beta-lactamase enzymes produced by resistant bacteria, protecting Cefoperazone from degradation and allowing it to exert its antimicrobial effects.

Together, the combination offers superior efficacy, especially in healthcare-associated and hospital-acquired infections caused by resistant strains.

Available Strengths and Compositions

BluepillExpress manufactures Cefoperazone & Sulbactam Injections in the following strengths:

• 1.5g (Cefoperazone 1000 mg + Sulbactam 500 mg)
• 2g (Cefoperazone 1000 mg + Sulbactam 1000 mg)

Other customized strengths and compositions are available upon client request.

Dosage Form and Packaging

Our standard dosage form is:

• Sterile dry powder for injection
• Packed in glass vials with flip-off seals
• Available with sterile water for injection (WFI) as needed

Packaging options include:

• Single vial with or without WFI
• Mono-carton with leaflet
• Hospital bulk packs

All packaging is compliant with export and regulatory guidelines, designed to maintain product stability, safety, and sterility.

Manufacturing Infrastructure

Our Cefoperazone & Sulbactam injections are manufactured in a dedicated sterile manufacturing facility equipped with:

• Class 100 sterile areas
• Automated vial filling and sealing systems
• Lyophilization (Freeze Drying) Units (if applicable)
• High-efficiency HVAC systems and HEPA filters
• Automated autoclaves and sterilization tunnels
• Dedicated QA/QC laboratories

Each production stage is conducted under strict aseptic conditions, ensuring zero contamination and consistent product quality.

Quality Control and Certifications

BluepillExpress follows stringent quality assurance protocols throughout the production lifecycle. Each batch of Cefoperazone & Sulbactam undergoes rigorous testing for:

• Potency
• Sterility
• Particulate Matter
• pH and Appearance
• Water content (Karl Fischer Method)
• Bacterial Endotoxins
• Compatibility with diluents

All products comply with international pharmacopeial standards including:

• United States Pharmacopeia (USP)
• British Pharmacopeia (BP)
• Indian Pharmacopeia (IP)

Certifications available:

• WHO-GMP
• ISO 9001:2015
• EU-GMP (select units)
• FSSAI (for nutraceutical lines)
• Halal and Kosher certifications (on request)

Regulatory and Documentation Support

BluepillExpress provides full regulatory support and documentation required for product registration and marketing in both regulated and semi-regulated markets. Documents include:

• Certificate of Pharmaceutical Product (COPP)
• Certificate of Analysis (COA)
• Stability Data
• Batch Manufacturing Records
• Product Master File (PMF)
• Material Safety Data Sheet (MSDS)
• Free Sale Certificate
• Manufacturing License and GMP Certificate
• Export documentation with barcoding, country-specific labeling, and traceability

Customization and Private Label Services

As a third-party manufacturer, BluepillExpress offers full-service private labeling and customization, including:

• Your brand name and logo
• Multilingual packaging and labeling
• Country-specific regulatory adaptations
• Flexible batch sizes
• Assistance with artwork and design files

Whether you are a hospital, government tender supplier, or a branded pharmaceutical firm, we offer scalable and customized solutions that meet your business objectives.

Export and Logistics Capabilities

With robust supply chain management and global logistics experience, we ensure:

• Timely dispatch of goods
• Packaging suited for long-distance and temperature-sensitive transport
• Customs clearance and export documentation support
• Cold chain management (if required)

We currently export to:

• Africa (Nigeria, Kenya, Ghana, South Africa)
• CIS countries
• Southeast Asia (Vietnam, Philippines, Myanmar)
• Middle East (UAE, Saudi Arabia, Oman)
• South America
• Caribbean and LATAM markets

Target Clients and Use Cases

We cater to a diverse range of clients:

• Government health departments
• Hospital chains
• Private pharmaceutical distributors
• Generic product exporters
• Branded marketing companies
• Contract manufacturers

Our Cefoperazone & Sulbactam product is highly suitable for hospital formularies, public health programs, emergency medicine kits, and high-dependency care units.

Why Choose BluepillExpress?

1. Global Export Reach
   Extensive experience in international compliance, logistics, and client servicing.
2. WHO-GMP Certified Manufacturing
   Facilities equipped for large-scale sterile production with global quality standards.
3. Customizable and Scalable Solutions
   Private label services, flexible batch sizes, and tailored packaging options.
4. Advanced Quality Control
   Full in-house testing ensures product safety, efficacy, and stability.
5. Regulatory Support
   End-to-end documentation assistance for fast-track product registration.
6. Reliable Delivery Timelines
   Well-coordinated supply chain and logistics partners ensure timely delivery worldwide.

Conclusion

As resistant infections continue to challenge modern medicine, Cefoperazone & Sulbactam offers a proven and reliable solution for broad-spectrum bacterial coverage. With its dual mechanism of action, this combination is increasingly becoming the preferred choice in intensive care settings, emergency rooms, and high-risk treatment protocols.

At BluepillExpress, we are proud to support global healthcare through safe, effective, and globally compliant third-party manufacturing of Cefoperazone & Sulbactam injections. Whether you’re looking to expand your injectables portfolio or launch a trusted antibiotic brand, we provide the expertise, infrastructure, and regulatory support you need to succeed.