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Helicobacter pylori (H. pylori) infections are among the leading causes of chronic gastritis, peptic ulcers, and even gastric cancer. To effectively eradicate this bacterium and prevent relapse, medical science has long relied on triple therapy regimens, with a combination of two antibiotics and a proton pump inhibitor (PPI). One of the most clinically proven combinations for this purpose is Amoxicillin + Clarithromycin + Esomeprazole.
At BluepillExpress, we offer reliable, high-quality third-party manufacturing of this triple therapy formulation in multiple dosage forms and customized strengths. Backed by WHO-GMP certifications, modern infrastructure, and regulatory expertise, we empower pharmaceutical companies, healthcare institutions, and distributors to introduce or expand their own branded versions of this combination therapy across global markets.
About BluepillExpress
BluepillExpress is a globally respected name in the field of pharmaceutical third-party manufacturing and international export. With a strong foundation in quality manufacturing practices, we support a wide range of clients in launching formulations across categories such as antibiotics, antacids, cardiovascular medicines, antidiabetics, and gastrointestinal treatments.
Our operations are guided by international benchmarks such as WHO-GMP, ISO 9001:2015, and EU-GMP (select facilities). We provide end-to-end contract manufacturing solutions, including product development, quality assurance, packaging, labeling, regulatory documentation, and global shipment.
Product Overview: Amoxicillin + Clarithromycin + Esomeprazole
This triple-drug therapy is primarily used in the eradication of H. pylori infections in patients suffering from:
- Peptic ulcers
- Gastric ulcers
- Duodenal ulcers
- Gastroesophageal reflux disease (GERD) with H. pylori
- Chronic gastritis and dyspepsia related to H. pylori
Each of the components plays a specific role:
- Amoxicillin, a broad-spectrum penicillin antibiotic, disrupts bacterial cell wall synthesis.
- Clarithromycin, a macrolide antibiotic, inhibits bacterial protein synthesis and enhances Amoxicillin’s effect.
- Esomeprazole, a proton pump inhibitor, reduces gastric acid secretion to enhance antibiotic stability and promote ulcer healing.
Standard Composition
Our standard triple therapy kits may include:
- Amoxicillin 1000 mg – twice daily
- Clarithromycin 500 mg – twice daily
- Esomeprazole 20 mg or 40 mg – once or twice daily
We also manufacture custom dosage strengths, pack sizes, and schedules upon client request.
Dosage Forms Offered
BluepillExpress manufactures Amoxicillin + Clarithromycin + Esomeprazole in various forms:
- Capsules (hard gelatin or HPMC-based)
- Tablets (film-coated, enteric-coated, or dispersible)
- Kit Packs (daily dose blister strips or box packs containing all three components)
- Sachets or powder formulations (on request for pediatric or geriatric use)
Each form is designed to ensure stability, bioavailability, and ease of administration.
Kit Packaging Options
We offer customizable kit packaging solutions, ideal for patient compliance and hospital protocols:
- Alu-Alu blister packs with calendar labeling
- Mono-carton boxes containing 7-day or 14-day course
- Multilingual printed inserts and dosing charts
- Tamper-proof, export-grade packaging material
We can customize packaging design and branding as per the client’s regulatory and marketing requirements.
Indications and Therapeutic Uses
The Amoxicillin + Clarithromycin + Esomeprazole combination is prescribed for:
- Eradication of H. pylori in peptic ulcer disease
- Adjunctive therapy for GERD with H. pylori
- Post-endoscopic eradication therapy for ulcers
- Preventing ulcer recurrence
- Combination therapy for gastric mucosa protection
It is considered first-line therapy for H. pylori by most gastroenterological associations globally.
Manufacturing Infrastructure
Our pharmaceutical manufacturing units meet stringent international standards, and include:
- Automated tablet compression and capsule filling units
- Dedicated antibiotic manufacturing zones
- HVAC-controlled cleanrooms
- High-precision blister packing machines
- Water purification systems conforming to pharmacopeial standards
- On-site quality control (QC) and microbiology laboratories
Each product batch is manufactured under hygienic, validated, and monitored conditions to ensure product integrity, sterility, and patient safety.
Quality Control and Compliance
At BluepillExpress, quality is paramount. All our products, including the Amoxicillin + Clarithromycin + Esomeprazole kit, undergo multiple layers of quality checks:
- Raw material testing
- In-process quality control (IPQC)
- Finished product testing
- Stability and shelf-life analysis
- Microbiological and dissolution studies
We manufacture as per the latest IP/BP/USP/Ph. Eur. standards, supported by:
- WHO-GMP Certification
- ISO 9001:2015 Accreditation
- GLP (Good Laboratory Practice) Standards
- FSSAI (for applicable formulations)
- USFDA (select manufacturing facilities)
Regulatory Support and Documentation
We assist clients with full regulatory documentation and product registration support for local and international markets, including:
- Certificate of Pharmaceutical Product (CoPP)
- Certificate of Analysis (CoA)
- Stability data and shelf-life report
- Drug Master File (DMF) / Product Dossier
- Manufacturing License and GMP Compliance
- Free Sale Certificate
- Import/export documentation and barcoding
- Pharmacovigilance and labeling compliance
This allows our clients to register and launch products efficiently in both regulated and semi-regulated markets.
Export Capabilities
BluepillExpress has an established footprint across 25+ countries, including:
- Asia: India, Vietnam, Sri Lanka, Bangladesh
- Africa: Kenya, Nigeria, Ghana, South Africa
- Middle East: UAE, Iraq, Jordan, Oman
- CIS Countries: Uzbekistan, Kazakhstan
- Latin America and Caribbean Nations
- Europe and UK (select certifications required)
We ensure product labeling and registration compliance for destination countries, including customs documentation, logistics support, and multi-language pack options.
Target Market and Clients
Our Amoxicillin + Clarithromycin + Esomeprazole combination is ideal for:
- Pharmaceutical marketing companies
- Hospital supply chains and tender bidders
- Generic product exporters
- Clinical research and institutional distributors
- Telehealth and digital pharmacy providers
The product is highly suitable for primary care, gastroenterology clinics, emergency settings, and general physician use.
Advantages of Partnering with BluepillExpress
- WHO-GMP Certified Manufacturing Facilities
Ensuring high quality, consistency, and regulatory acceptance globally. - Flexible MOQ and Batch Sizes
Suitable for startups, government tenders, and multinational expansions. - End-to-End Private Labeling Support
From brand design to export packaging and marketing aids. - Quick Turnaround Time and Global Logistics
Seamless production timelines and reliable international dispatch. - Technical and Regulatory Expertise
Assistance with dossier preparation, bioequivalence references, and compliance. - Quality You Can Trust
Each formulation backed by rigorous analytical testing, scientific validation, and international benchmarks.
Conclusion
The triple combination of Amoxicillin, Clarithromycin, and Esomeprazole remains a cornerstone of H. pylori eradication and gastrointestinal healing protocols. With rising cases of antibiotic resistance and recurring peptic ulcers, the demand for ready-to-administer therapy kits is increasing rapidly across the globe.
At BluepillExpress, we take pride in delivering clinically relevant, export-ready, and GMP-compliant triple therapy solutions. Whether you’re looking to launch your own brand, supply hospitals, or expand your product offerings in the gastrointestinal therapeutics segment, our third-party manufacturing solutions provide you with the tools and expertise needed for global success.
