Betamethasone & Clioquinol

Skin infections, inflammatory dermatoses, and mixed microbial skin conditions are among the most frequently encountered issues in dermatological practice. Effective management often requires a combination of anti-inflammatory and antimicrobial agents. The formulation of Betamethasone and Clioquinol is widely used for treating eczema, dermatitis, and fungal or bacterial skin infections, offering both rapid relief and therapeutic action.

BluepillExpress, a WHO-GMP certified pharmaceutical manufacturing company, offers high-quality, customized third-party manufacturing of Betamethasone & Clioquinol topical formulations. Our services cater to hospitals, dermatology brands, generic companies, government procurement agencies, and international distributors. We specialize in delivering formulations that are compliant, effective, scalable, and tailored to global standards.

What is Betamethasone & Clioquinol?

Betamethasone is a potent corticosteroid with anti-inflammatory, antipruritic, and vasoconstrictive properties. It reduces redness, swelling, itching, and inflammation associated with various dermatological conditions by suppressing the migration of polymorphonuclear leukocytes and reversing capillary permeability.

Clioquinol, also known as iodochlorhydroxyquin, is an antifungal and antibacterial agent. It works against Gram-positive bacteria and dermatophytes by interfering with microbial DNA replication and metabolic processes. The combination is especially effective in treating superficial skin infections with inflammatory components.

Together, they form a topical therapy for mixed infections—both infectious and inflammatory in origin—with a fast onset of action and excellent patient tolerability.

Therapeutic Class

• Topical Corticosteroid (Betamethasone)
• Topical Antifungal and Antibacterial (Clioquinol)
• Dermatological Combination Therapy

Key Benefits of Betamethasone & Clioquinol

1. Powerful Anti-Inflammatory Action

Betamethasone effectively reduces swelling, itching, and erythema, bringing relief in inflammatory skin conditions such as eczema, dermatitis, and psoriasis.

2. Broad-Spectrum Antimicrobial Activity

Clioquinol acts against a wide range of fungi (e.g., dermatophytes) and bacteria, making it suitable for secondary infections and infected dermatoses.

3. Combination Effectiveness

The combination addresses both the symptomatic inflammation and underlying infection, making it ideal for mixed etiologies often seen in clinical dermatology.

4. Well-Tolerated Topical Use

When used appropriately, the formulation is safe for short-term therapy with minimal systemic absorption and adverse effects.

5. Multiple Formulation Options

BluepillExpress manufactures the combination in various forms including creams, ointments, and lotions, giving physicians and patients flexibility in use.

Indications

Betamethasone & Clioquinol is indicated for the treatment of:

• Eczematous dermatoses (with or without secondary infection)
• Atopic dermatitis and seborrheic dermatitis
• Contact dermatitis
• Psoriasis with secondary infection
• Tinea corporis, cruris, and pedis (fungal infections)
• Infected insect bites, intertrigo, and minor cuts
• Chronic pruritic conditions with microbial colonization
• Otitis externa (in lotion form, with medical guidance)

It is generally prescribed for short-term topical use under the supervision of a healthcare provider.

Available Formulations and Strengths

BluepillExpress offers a wide range of topical formulations of Betamethasone + Clioquinol, customized as per client needs and regulatory requirements:

Topical Cream

• Betamethasone Dipropionate 0.05% w/w + Clioquinol 1% w/w

Topical Ointment

• Betamethasone Valerate 0.1% w/w + Clioquinol 3% w/w

Topical Lotion (on request)

• Ideal for use in scalp or hairy regions
• Customized strengths available on demand

Each product is manufactured using pharma-grade excipients, with optimized pH balance, skin absorption, and shelf stability. Packaging is designed for extended shelf life, patient safety, and brand visibility.

Dosage and Administration

• Apply a thin layer of the cream, ointment, or lotion to the affected area once or twice daily, depending on the severity of the condition and physician’s recommendation.
• Do not exceed the prescribed duration (typically not beyond 7–14 days) to avoid potential corticosteroid-related side effects such as skin thinning.

Cautions:

• Avoid contact with eyes and mucous membranes.
• Not suitable for use in deep or systemic fungal infections.
• Should not be used under occlusive dressings unless advised.
• Pediatric use should be limited and supervised.

Pharmacological Profile

Betamethasone:

• Class: Potent topical corticosteroid
• Mechanism: Reduces inflammation by suppressing inflammatory mediators and immune response
• Onset: Rapid relief within 1–3 days of use
• Systemic Absorption: Minimal when used topically and as directed

Clioquinol:

• Class: Halogenated hydroxyquinoline derivative
• Mechanism: Disrupts microbial enzyme systems and DNA replication
• Active Against: Dermatophytes, Candida, and Gram-positive bacteria
• Resistance: Low potential; used widely for superficial infections

Together, they provide both symptomatic relief and microbiological cure, minimizing recurrence and improving skin health outcomes.

Manufacturing Capabilities

At BluepillExpress, we use advanced manufacturing equipment and validated processes to ensure consistency, safety, and quality.

Facilities and Capacity:

• Dedicated dermatology manufacturing suites
• Cleanroom-compliant filling and sealing lines
• Cream and ointment manufacturing with homogenizers and mixers
• Automatic tube filling (laminated and aluminum options)
• High-speed labeling and cartoning units

We support low, medium, and high-volume production with flexibility for:

• Private-label branding
• Institutional packaging
• Bulk export orders

Packaging and Design

Our topical products are packaged to maintain efficacy, stability, and hygiene, while also enhancing brand visibility.

Primary Packaging:

• Aluminum tubes (5g, 15g, 30g sizes)
• Laminated tubes for high moisture protection
• HDPE bottles (for lotion formulations)

Secondary Packaging:

• Custom monocartons with foil stamping or spot UV options
• Multilingual printing and country-specific artwork
• Batch number, Mfg/Exp, and labeling as per local regulations
• Tamper-proof seals and patient inserts included

We offer custom design support, or work with client-provided branding elements for full-service OEM solutions.

Quality Assurance and Regulatory Compliance

Our products are developed and manufactured in line with international pharmaceutical standards:

Certifications:

• WHO-GMP
• ISO 22000:2018
• FSSAI (where applicable)
• FDA India Manufacturing License
• Regulatory dossier support for ROW and semi-regulated markets

QA & QC Measures:

• In-process checks (homogeneity, fill weight, pH, viscosity)
• Microbial testing (TAMC, TYMC)
• Assay of active ingredients
• Stability studies under ICH Zone II & IVB
• Final product review and batch release documentation

Each product is backed by Certificate of Analysis (CoA) and full technical files for international registration.

Documentation and Export Support

We offer full documentation and regulatory assistance to enable fast market entry and tender participation.

Documents Provided:

• Certificate of Analysis (CoA)
• Certificate of Pharmaceutical Product (COPP)
• Free Sale Certificate (FSC)
• Certificate of Origin (COO)
• MSDS (Material Safety Data Sheet)
• CTD/ACTD format dossiers (Modules 1–5)
• Stability data
• Product image and artwork files

Our dedicated export team ensures efficient documentation preparation, customs clearance, and compliance with import norms.

Shipping and Global Reach

We serve clients across Asia, Africa, Latin America, CIS, and the Middle East, and can handle both commercial and humanitarian supplies.

Shipping Options:

• Incoterms: EXW, FOB, CIF, DDP
• Logistics support by air or sea freight
• Cold chain (if required for specific formulations)
• Shrink-wrapped, palletized consignments
• Real-time tracking and export compliance assistance

MOQ and Production Lead Times

Product Type	Minimum Order Quantity	Lead Time
Betamethasone + Clioquinol Cream	50,000 tubes	20–25 working days
Betamethasone + Clioquinol Ointment	50,000 tubes	20–25 working days
Sample Development	20–50 tubes	7–10 working days

Lead times may vary based on packaging customization, regulatory approvals, and labeling requirements.

Market Demand and Opportunities

The combination of Betamethasone & Clioquinol is highly relevant in markets with:

• High incidence of dermatophytosis and secondary skin infections
• Demand for affordable topical anti-inflammatory/antimicrobial agents
• Inclusion in essential medicine lists and public health tenders
• OTC and prescription market potential in dermatology

With increased awareness of skin hygiene and fast-acting topical remedies, this product offers great opportunities in private label and institutional supply segments.

Ideal Partners

We partner with:

• Dermatology-focused pharmaceutical marketers
• Generic pharma exporters
• Hospital procurement agencies
• Retail skincare brands and OTC providers
• Public health distributors and NGOs
• Government and institutional tender suppliers

We provide turnkey solutions, from product development to regulatory documentation and shipment logistics.

Why Choose BluepillExpress?

• WHO-GMP certified and export-ready manufacturing
• Proven experience in dermatological formulation manufacturing
• End-to-end support for private label and international registrations
• Consistent quality, affordable pricing, and timely delivery
• Scalable production model tailored to your growth

Conclusion

The Betamethasone & Clioquinol combination is a time-tested, effective, and patient-friendly solution for various skin conditions marked by inflammation and infection. Whether for private label brands or institutional supply, this formulation remains a key therapeutic offering in global dermatology.

With BluepillExpress as your trusted third-party manufacturing partner, you gain access to high-quality products, regulatory expertise, and global distribution support—all under one roof.