Propranolol Hydrochloride

In today’s world, where cardiovascular diseases and stress-related disorders are increasing at a global level, Propranolol Hydrochloride continues to be a cornerstone in the management of several cardiovascular and neurological conditions. As a non-selective beta-adrenergic receptor blocker, Propranolol has decades of clinical use and remains one of the most prescribed medications for treating hypertension, anxiety, angina, migraine, arrhythmias, and various other conditions.

At BluepillExpress, we offer premium-quality third-party manufacturing of Propranolol Hydrochloride in multiple dosage forms and strengths. Backed by a WHO-GMP-compliant facility, stringent quality controls, and robust export infrastructure, we support pharmaceutical companies and healthcare providers globally in sourcing reliable, affordable, and regulatory-compliant beta-blocker formulations.

About BluepillExpress

BluepillExpress is a globally recognized name in pharmaceutical third-party manufacturing and international contract manufacturing services. With a strong footprint across Asia, Africa, the Middle East, CIS, and Latin America, we support private labels, hospitals, pharmacies, and marketing companies with customized product development, scalable batch production, and global logistics support.

Our capabilities extend to:

• WHO-GMP-certified manufacturing
• ISO 9001:2015 quality systems
• Product development and R&D
• Dossier and regulatory documentation
• Custom branding and private labeling
• Bulk and small-batch capabilities

Whether you are launching a new product or expanding an existing portfolio, BluepillExpress is your trusted partner for quality-centric pharmaceutical manufacturing.

Product Overview: Propranolol Hydrochloride

Propranolol Hydrochloride is a non-selective beta-adrenergic blocking agent that acts by blocking both β1 and β2 receptors. This action results in reduced heart rate, myocardial contractility, and blood pressure. Additionally, it decreases renin secretion and helps in controlling arrhythmic conditions and anxiety symptoms related to excessive sympathetic stimulation.

Propranolol is indicated for the treatment of:

• Hypertension (high blood pressure)
• Angina pectoris (chest pain)
• Cardiac arrhythmias (especially supraventricular tachycardia)
• Myocardial infarction (to prevent recurrence)
• Migraine prophylaxis
• Essential tremor
• Hyperthyroidism-related symptoms
• Anxiety and performance-related stress
• Portal hypertension and esophageal varices (off-label use)

Its long-standing safety profile and versatility across therapeutic categories make it an essential product in both primary and specialized care.

Mechanism of Action

Propranolol Hydrochloride acts by competitively blocking beta-1 and beta-2 adrenergic receptors. This results in:

• Decreased heart rate and cardiac output
• Lowered blood pressure
• Inhibition of renin release from the kidneys
• Reduced oxygen demand of the heart
• Blunting of the physical symptoms of anxiety

Due to its ability to cross the blood-brain barrier, Propranolol is also effective in managing migraine prophylaxis, essential tremors, and generalized anxiety disorders, particularly performance anxiety.

Available Dosage Forms

BluepillExpress manufactures Propranolol Hydrochloride in various oral dosage forms, ensuring high bioavailability, dose precision, and compliance:

1. Propranolol Hydrochloride Tablets

• 10 mg
• 20 mg
• 40 mg
• 80 mg
• 160 mg (on request)
• Film-coated, uncoated, or dispersible options available

2. Propranolol Hydrochloride Extended Release (ER) Capsules

• 60 mg
• 80 mg
• 120 mg
• 160 mg

3. Propranolol Oral Solution or Syrup (customizable for pediatric/geriatric use)

• 5 mg/ml or 10 mg/ml
• Sugar-free and flavored variants available

All products comply with IP, BP, USP, and Ph. Eur. standards as required by destination markets.

Packaging Formats

We offer flexible and export-compliant packaging solutions to suit different regional regulations and branding needs:

For Tablets:

• Blister packs (PVC/Alu or Alu-Alu)
• Strip packaging (1×10, 10×10, or 1×15)
• Bulk tablet packs for institutional supply
• Mono-cartons with or without inserts

For Extended-Release Capsules:

• HDPE containers or blister strips
• Child-resistant closures available
• Calendar packs for better compliance

For Oral Solutions:

• Amber or white HDPE bottles with child-proof caps
• Dosing spoon, cup, or oral syringe included
• Multilingual labeling options

All packaging is compliant with FDA, EMA, and local country-specific regulations.

Manufacturing Facilities and Infrastructure

Our Propranolol Hydrochloride formulations are manufactured in WHO-GMP-certified plants equipped with:

• Advanced blending, granulation, and tablet compression units
• Fluid bed processors for controlled-release formulations
• In-process quality control checkpoints
• Automatic capsule filling lines
• Oral solution filling and labeling systems
• HVAC-controlled cleanrooms
• In-house purified water systems (USP/BP compliant)
• State-of-the-art microbiology and analytical testing labs

We ensure that every batch undergoes stringent quality checks and meets international compliance standards.

Quality Control and Compliance

Quality is the foundation of our manufacturing philosophy. Our Quality Assurance (QA) and Quality Control (QC) teams ensure that each formulation meets safety, efficacy, and consistency standards.

Our QC protocol for Propranolol includes:

• Raw material identity and assay
• In-process and finished product testing
• Dissolution and disintegration analysis
• Stability studies (real-time and accelerated)
• Microbial limit testing
• Container-closure integrity testing

Certifications and compliance benchmarks include:

• WHO-GMP
• ISO 9001:2015
• GLP (Good Laboratory Practices)
• FSSAI (for applicable dosage forms)
• EU-GMP and USFDA (available for select plants)

Regulatory Documentation Support

We provide comprehensive regulatory documentation for both domestic and international product registrations, including:

• Certificate of Pharmaceutical Product (CoPP)
• Certificate of Analysis (CoA)
• Drug Master File (DMF) or Common Technical Document (CTD) dossiers
• Stability data and validation reports
• Free Sale Certificate
• Manufacturing License and GMP certification
• Product labels, inserts, and packaging samples
• Material Safety Data Sheet (MSDS)

Our dedicated regulatory team supports pharmaceutical companies, importers, and government entities in obtaining product registration across regulated, semi-regulated, and developing markets.

Export Market and Logistics Support

With exports to over 25+ countries, BluepillExpress has a proven track record in handling international distribution and customs compliance. Our major export destinations include:

• Africa: Nigeria, Kenya, Ghana, Uganda, South Africa
• Asia: Vietnam, Myanmar, Sri Lanka, Philippines, Bangladesh
• Middle East: Iraq, UAE, Saudi Arabia, Jordan, Oman
• CIS: Kazakhstan, Uzbekistan, Georgia
• Latin America: Bolivia, Peru, Dominican Republic

We offer:

• International logistics support (sea and air freight)
• Export documentation (invoice, packing list, CoA, etc.)
• Country-specific labeling and barcoding
• Regulatory approval and customs clearance assistance
• Temperature-controlled shipping (on request)

Target Customers and Applications

Our Propranolol Hydrochloride formulations are ideal for:

• Branded and generic pharmaceutical companies
• Government tender suppliers and NGOs
• Hospitals and multispecialty clinics
• Cardiology and neurology specialists
• Online pharmacy platforms and digital health providers
• Public health institutions and procurement agencies

We offer low MOQs, scalable production, and tailored private labeling, making our services ideal for both startups and large-scale distributors.

Why Choose BluepillExpress?

1. WHO-GMP and ISO-Certified Manufacturing
   Assuring global standard quality and regulatory acceptance.
2. Custom Branding and Labeling
   Personalized packaging and brand identity creation for global markets.
3. Complete Regulatory Support
   Dossier preparation, artwork approval, CoPP, CoA, and more.
4. Competitive Pricing and Scalable Production
   Cost-effective solutions for all order volumes—small batches to bulk supply.
5. Reliable Global Export and Logistics
   End-to-end management of documentation, customs, and delivery.
6. Proven Track Record in Beta-Blocker Manufacturing
   Decades of experience in cardiovascular formulation manufacturing.

Conclusion

Propranolol Hydrochloride remains a cornerstone therapy for a wide range of cardiovascular and neuro-psychiatric disorders. With its expanding indications and increasing demand in both developed and developing markets, it is a valuable asset for any pharmaceutical brand or distributor.

At BluepillExpress, we combine pharmaceutical expertise, regulatory strength, and international logistics to provide world-class third-party manufacturing solutions. Whether your goal is domestic distribution or global export, we deliver quality you can trust—every time.