Prazosin Hydrochloride

Prazosin Hydrochloride is an alpha-1 adrenergic receptor blocker used in the management of hypertension, benign prostatic hyperplasia (BPH), and post-traumatic stress disorder (PTSD)-associated nightmares. As a well-established antihypertensive agent with additional urological and psychiatric benefits, Prazosin Hydrochloride has secured a significant position in essential drug lists globally.

BluepillExpress, a leading pharmaceutical manufacturer and exporter, offers third-party and contract manufacturing services for Prazosin Hydrochloride across various strengths and dosage forms. Our world-class infrastructure, stringent regulatory compliance, and commitment to quality make us a reliable partner for global pharmaceutical brands, hospitals, government tenders, and institutional buyers.

Product Overview

Product Name: Prazosin Hydrochloride
Therapeutic Class: Alpha-1 Adrenergic Receptor Blocker (Antihypertensive/Urological Agent)
Available Dosage Forms:

• Tablets: 1 mg, 2 mg, 5 mg
• Extended-release tablets or capsules (custom development available upon request)

Route of Administration: Oral
Packaging Options:

• Blister packs (PVC/Alu or Alu-Alu), typically 10×10 or 1×10 format
• Bottle packs (HDPE/PET bottles for institutional supply)
• Mono-cartons with product insert (as per regulatory requirements)

Mechanism of Action

Prazosin Hydrochloride works by selectively blocking postsynaptic alpha-1-adrenergic receptors, leading to vasodilation of both arteries and veins. This results in a decrease in peripheral vascular resistance, thereby lowering blood pressure.

In the context of benign prostatic hyperplasia, the drug relaxes smooth muscle in the bladder neck and prostate, improving urine flow. In patients with PTSD, the drug is believed to mitigate hyperarousal and reduce trauma-related nightmares, though its exact mechanism in this indication is not fully established.

Indications

Prazosin Hydrochloride is indicated for:

• Essential Hypertension: Alone or in combination with other antihypertensives
• Benign Prostatic Hyperplasia (BPH): For symptomatic relief of urinary obstruction
• PTSD-related Nightmares and Sleep Disturbances
• Congestive Heart Failure (CHF): As adjunct therapy
• Raynaud’s Phenomenon and other off-label indications (as per regional clinical practices)

The drug’s versatility across cardiovascular, urological, and psychiatric domains broadens its market appeal and therapeutic demand.

Pharmacokinetics and Dosing Considerations

• Absorption: Rapid following oral administration
• Bioavailability: Approximately 60–70%
• Onset of Action: Within 2–4 hours
• Half-life: 2–4 hours (short-acting); extended-release formulations are available
• Excretion: Primarily via feces and urine

Initial dosing is critical due to the risk of first-dose hypotension. Most regimens begin with 1 mg at bedtime and are titrated based on patient response.

Why Choose BluepillExpress for Prazosin Hydrochloride Manufacturing?

1. WHO-GMP and ISO-Certified Production Facilities

BluepillExpress operates from WHO-GMP, ISO 9001:2015, and FSSAI-approved facilities with segregated zones for cardiovascular drug production. Our tablet manufacturing lines utilize advanced equipment for granulation, compression, coating, and blistering, ensuring uniform quality and regulatory compliance.

2. Regulatory Compliance and Global Documentation

We support full regulatory documentation for domestic and international product registrations. Available documents include:

• Certificate of Analysis (CoA)
• Batch Manufacturing Records (BMR)
• Stability Data (Accelerated & Long-term)
• Method of Analysis (MoA)
• Product Specifications & MSDS
• Certificate of Origin & Free Sale Certificate
• CTD/ACTD Dossier (available upon request)
• Pharmacopoeial compliance (IP/USP/BP/EP)

Our formulations are accepted in markets across Asia, Africa, CIS, Latin America, and the Middle East.

Dosage Formulations and Customization

We provide complete flexibility in formulation development, including:

• Standard immediate-release tablets (1 mg, 2 mg, 5 mg)
• Extended-release tablets or capsules for once-daily dosing (optional)
• Scored tablets for accurate dose titration
• Film-coated tablets for improved swallowing and appearance
• Sugar-free, colorant-free, or lactose-free variants upon request

Our team also supports bioequivalence studies and BE-ready formulations for markets with higher regulatory demands.

Packaging and Private Labeling Services

We offer packaging services tailored to private labeling and global distribution needs:

• Multilingual packaging options for export markets
• Custom-designed blister cards or bottle labels
• Brand name printing and batch/expiry coding
• Serialization and QR codes (compliant with US DSCSA and EU FMD)
• Tamper-evident mono-cartons and patient leaflets

We assist clients in artwork development, regulatory mock-ups, and packaging validation, helping you deliver a brand-ready product with minimal lead time.

Quality Assurance and Testing

Our QA/QC protocols ensure that each batch of Prazosin Hydrochloride meets global pharmacopeial standards. In-house labs are equipped for:

• Assay and content uniformity
• Dissolution and disintegration testing
• Impurity profiling and residual solvent analysis
• Microbiological testing
• Stability studies under ICH guidelines
• Moisture content, friability, and hardness testing
• Packaging integrity and shelf-life validation

All tests are conducted per validated protocols and reviewed by qualified QA professionals before product release.

Global Export and Tender Supply

BluepillExpress has an established global export network, serving pharmaceutical distributors, government health ministries, and procurement agencies in over 35 countries.

Our international trade team ensures:

• Country-specific registration and compliance assistance
• Export documentation: Invoice, Packing List, CoA, COO, Free Sale Certificate
• Third-party inspection support (SGS, Intertek, Bureau Veritas)
• Cold-chain logistics or controlled room-temperature shipping (as needed)
• Project-based fulfillment for institutional or NGO supplies

We are experienced in working with WHO, UN organizations, government tenders, and public health contracts.

Third-Party Manufacturing Workflow

Our well-structured third-party manufacturing process ensures transparency, speed, and quality. The typical steps include:

1. Product Requirement Finalization
   • Dosage form, strength, packaging, regulatory scope
2. Commercial Agreement and Quotation
   • Pricing, MOQ, lead time, IP protection agreement
3. Formulation Customization (if required)
   • Optional R&D support for new variants or formulations
4. Production and In-Process QC
   • Manufacturing under GMP-compliant conditions
5. Packaging and Labeling
   • Customized as per market-specific norms
6. Documentation and Dispatch
   • Export coordination with all necessary paperwork

Standard turnaround time: 30–40 working days (may vary based on order size and customization).

Client Profiles and Target Markets

Our Prazosin Hydrochloride products are well-suited for:

• Pharmaceutical distributors and marketing companies
• Hospital chains and healthcare procurement bodies
• Government medical supply agencies and tenders
• NGOs and public health organizations
• Wholesalers and contract buyers in regulated and semi-regulated markets

The demand for Prazosin continues to grow with its increasing usage in both primary hypertension and evolving psychiatric indications like PTSD. We cater to both retail and institutional demand models.

Key Advantages of Partnering with BluepillExpress

• WHO-GMP-compliant production of cardiovascular medicines
• Full-spectrum support for regulatory filings and market entry
• High-speed execution of third-party/private label manufacturing
• Competitive pricing and scalable order fulfillment
• Responsive after-sales and pharmacovigilance support
• Transparent operations and confidential client engagement

Whether you’re entering a new market or expanding your current portfolio, we provide you with a robust manufacturing backbone to build long-term success.

Conclusion

Prazosin Hydrochloride offers a unique position in cardiovascular, urological, and psychiatric care, making it a multifaceted product with stable market demand. With increasing global focus on non-communicable diseases and mental health disorders, this drug remains a vital therapeutic option.

At BluepillExpress, we combine technical precision, regulatory excellence, and customized service to deliver Prazosin Hydrochloride formulations that align with your branding and compliance needs. From formulation to final packaging and global delivery, we ensure a seamless, compliant, and reliable manufacturing partnership.