Nebivolol

Hypertension and heart-related conditions remain critical health issues affecting millions of individuals globally. With the increasing emphasis on cardio-selective beta-blockers that offer high efficacy with minimal side effects, Nebivolol has emerged as a preferred choice among healthcare professionals. As a third-generation beta-blocker with vasodilatory properties, Nebivolol offers a unique dual mechanism for blood pressure control and heart rate regulation.

At BluepillExpress, we offer world-class third-party manufacturing services for Nebivolol formulations, engineered to meet global demand and comply with the highest standards of pharmaceutical excellence. With a strong focus on innovation, compliance, and quality, we manufacture Nebivolol products tailored to the evolving needs of our partners and their target markets.

About BluepillExpress

BluepillExpress is a globally trusted third-party pharmaceutical manufacturing company, committed to delivering world-class medicines at cost-effective rates. With a network spanning 30+ countries across Asia, Africa, the Middle East, CIS, and Latin America, we specialize in:

• Contract and third-party manufacturing of pharmaceuticals and nutraceuticals
• WHO-GMP, ISO 9001:2015 certified production facilities
• Regulatory-compliant packaging and documentation
• Customizable private label and export-ready solutions
• R&D-backed formulation development

Our manufacturing infrastructure and operational capabilities are designed to serve large-scale pharmaceutical distributors, hospitals, public tenders, and private brands globally.

Product Overview: Nebivolol

Nebivolol is a cardioselective beta-1 adrenergic receptor blocker with vasodilatory properties mediated by nitric oxide release. It is particularly effective in reducing peripheral vascular resistance and improving cardiac output without significantly impacting pulmonary or metabolic functions, making it ideal for hypertensive patients with comorbidities.

Therapeutic Class: Beta-Blocker (Beta-1 Selective Adrenergic Antagonist)
Pharmacological Action: Beta-1 receptor blockade with nitric oxide-mediated vasodilation

Dosage Strengths Offered:

• Nebivolol 2.5 mg
• Nebivolol 5 mg
• Nebivolol 10 mg

Available Forms:

• Oral Tablets (film-coated or plain tablets)

Customized formulations and combination therapies (e.g., Nebivolol + Hydrochlorothiazide) are available upon request.

Mechanism of Action

Nebivolol reduces blood pressure by two synergistic mechanisms:

1. Beta-1 receptor blockade: Reduces heart rate and myocardial contractility, lowering cardiac output.
2. Endothelium-mediated vasodilation: Enhances nitric oxide release, improving vascular tone and decreasing peripheral resistance.

This dual mechanism results in better blood pressure control, enhanced tolerability, and improved long-term cardiovascular outcomes.

Therapeutic Indications

Nebivolol is widely prescribed for:

• Hypertension (primary and essential)
• Chronic heart failure (mild to moderate severity)
• Angina pectoris (adjunctive treatment)
• Post-myocardial infarction (long-term maintenance therapy)
• Atrial fibrillation or tachycardia (off-label uses)

Its selective profile and nitric oxide-based action make it especially suitable for elderly patients or those with diabetes and metabolic syndrome.

Key Advantages of Nebivolol

• Cardioselective with minimal impact on respiratory function
• Nitric oxide-mediated vasodilation offers better endothelial protection
• Superior tolerability with fewer central nervous system side effects
• Lower incidence of fatigue, depression, and sexual dysfunction compared to older beta-blockers
• Once-daily dosing with long half-life
• Ideal for monotherapy or combination therapy in complex hypertensive cases

Manufacturing Capabilities at BluepillExpress

BluepillExpress operates a WHO-GMP compliant, ISO-certified facility with specialized lines for cardiovascular medications. We ensure that every Nebivolol tablet is produced with precision, consistency, and safety:

• Granulation and Blending Units for uniform active ingredient dispersion
• High-Speed Compression Machines for optimal tablet weight and hardness
• Film-Coating Units for enhanced tablet stability and palatability
• De-dusting and Metal Detection Systems for added safety assurance
• Air-Handling Units (AHUs) to control humidity and prevent cross-contamination

Our automated and semi-automated machinery allows both high-volume and small-batch production, making us suitable for startups and large-scale distributors alike.

Packaging & Presentation Options

We offer customized packaging formats to meet specific branding, compliance, and market preferences:

Tablet Packaging:

• Alu-Alu blister packs (10×10, 10×15, 10×6)
• Alu-PVC blister strips
• HDPE bottles with desiccants for institutional and hospital supply

Labeling & Branding:

• Private label branding with client-provided artwork
• Multilingual inserts and dosage instructions
• Tamper-evident seals and optional holographic features
• Barcoding and serialization as per track & trace mandates

All packaging is tested for moisture resistance, light protection, and tamper-proof integrity.

Quality Assurance & Control

Our Quality Control (QC) and Quality Assurance (QA) teams ensure that every batch of Nebivolol meets international standards of efficacy and safety:

• Raw Material Analysis: Identity, purity, assay, microbial limits
• In-Process Testing: Weight variation, content uniformity, hardness, friability
• Finished Product Testing: Assay, dissolution, disintegration, microbial load
• Stability Studies: Conducted under ICH guidelines (Zone II and IV conditions)
• Documentation: Batch Manufacturing Record (BMR), Certificate of Analysis (CoA), Material Safety Data Sheet (MSDS)

Products comply with IP/USP/BP/EP standards based on client requirements.

Shelf Life and Storage Conditions

• Shelf Life: 24 to 36 months
• Storage Conditions: Store below 30°C, protected from light and moisture
• Coated tablets offer better environmental stability in tropical and temperate zones

Regulatory and Export Documentation

BluepillExpress supports clients with comprehensive regulatory documentation to facilitate market entry across global territories:

• Certificate of Pharmaceutical Product (COPP)
• Free Sale Certificate
• GMP Certificate
• Certificate of Analysis (CoA)
• CTD/ACTD Dossier support
• Stability and Bioequivalence data (on request)
• Product Artwork and Label Templates

We also assist with product registration, import licensing, and regulatory representation in key export markets.

Private Label & Customization Services

We empower pharmaceutical brands to launch or expand their cardiovascular portfolio under private label arrangements:

• Brand name and logo integration
• Custom artwork, carton, and label design
• Dosing leaflets in multiple languages
• Brand-specific marketing materials and samples
• Market exclusivity (on negotiated terms)

Minimum Order Quantities (MOQs) are flexible, allowing easy market testing for new entrants or product line extensions.

Global Logistics & Supply Chain Management

We deliver export-ready Nebivolol formulations with full support for international shipping and compliance:

• International air/sea/courier dispatch options
• Temperature and humidity-controlled logistics (as required)
• Coordination with certified freight forwarders
• Country-specific documentation and labeling standards
• Multi-modal packaging solutions for bulk and retail formats

We ensure timely delivery, real-time tracking, and full post-shipping support to all partners.

Target Customers & Ideal Partners

Our Nebivolol manufacturing solutions cater to:

• Generic and branded pharmaceutical companies
• Government and institutional suppliers
• Cardiovascular product portfolio marketers
• OTC and prescription drug distributors
• Tender-based procurement agencies
• Retail pharmacy and hospital chains

Why Choose BluepillExpress for Nebivolol Manufacturing?

• WHO-GMP and ISO-certified manufacturing excellence
• Proven track record in cardiovascular therapeutic manufacturing
• R&D expertise to support customization and combination therapies
• Regulatory documentation and dossier support for 30+ global markets
• Flexible production volumes and private label options
• Competitive pricing and reliable supply timelines
• End-to-end confidentiality and IP protection

Conclusion

Nebivolol continues to gain global acceptance as a safe, modern beta-blocker with superior cardiovascular and metabolic benefits. As a trusted partner in pharmaceutical manufacturing, BluepillExpress offers comprehensive third-party manufacturing for Nebivolol, combining scientific precision with international compliance to serve healthcare needs around the world.

With our advanced infrastructure, quality systems, and customer-first approach, BluepillExpress is your ideal manufacturing partner for Nebivolol — whether you’re entering new markets, scaling your portfolio, or seeking regulatory-ready, export-quality cardiovascular medications.