Acetazolamide

Acetazolamide is a potent carbonic anhydrase inhibitor used in the treatment of various medical conditions, including glaucoma, epilepsy, altitude sickness, diuretic-induced metabolic alkalosis, and congestive heart failure-associated edema. Its multifaceted mechanism of action and broad clinical applications make Acetazolamide a valuable pharmaceutical product across both emergency and chronic care segments.

At BluepillExpress, we specialize in the third-party manufacturing of Acetazolamide and its derivatives, providing pharmaceutical companies, hospital chains, government bodies, and global exporters with reliable, high-quality formulations compliant with international regulatory standards. With a world-class infrastructure, a commitment to innovation, and a global export reach, BluepillExpress is the trusted partner for businesses seeking superior manufacturing services for Acetazolamide.

About Acetazolamide

Acetazolamide is classified as a carbonic anhydrase inhibitor. By inhibiting the enzyme carbonic anhydrase, it reduces the formation of hydrogen and bicarbonate ions from carbon dioxide and water, leading to decreased aqueous humor production in the eye and increased excretion of bicarbonate in the kidneys.

The medication is used for various indications including:

• Glaucoma: To reduce intraocular pressure
• Altitude Sickness (Acute Mountain Sickness): As a prophylactic and treatment agent
• Epilepsy: As an adjunctive therapy in specific types of seizures
• Periodic Paralysis: In the treatment of both hypokalemic and hyperkalemic periodic paralysis
• Edema: Associated with heart failure or drug-induced fluid retention
• Pseudotumor Cerebri: To decrease cerebrospinal fluid (CSF) pressure

Its unique ability to cross the blood-brain barrier and its prompt action make it essential in both hospital and outpatient settings. Acetazolamide is listed on the World Health Organization’s List of Essential Medicines, underscoring its global clinical relevance.

Why Choose BluepillExpress for Acetazolamide Manufacturing?

BluepillExpress provides end-to-end third-party and contract manufacturing services for Acetazolamide, offering unparalleled product quality, scalability, and regulatory support. With our manufacturing facilities adhering to WHO-GMP, ISO 9001:2015, and FSSAI standards, clients can trust us to deliver fully compliant and market-ready Acetazolamide formulations.

Our offerings include:

• High-volume batch production
• Private label and white label manufacturing
• Custom formulations as per country-specific regulations
• Full regulatory documentation support (CTD/eCTD format)
• Global export and logistics coordination

We pride ourselves on being a flexible and responsive manufacturing partner, able to support both large pharmaceutical corporations and emerging healthcare brands.

Dosage Forms and Strengths Offered

BluepillExpress manufactures Acetazolamide in a range of dosage forms and strengths, meeting global therapeutic standards and patient preferences.

1. Acetazolamide Tablets

• Strengths: 125 mg, 250 mg, 500 mg
• Dosage Form: Oral tablets (film-coated or uncoated)
• Indications: Glaucoma, epilepsy, edema, altitude sickness
• Packaging Options: Blister packs, alu-alu packs, strip packs
• Shelf Life: 24–36 months depending on packaging and formulation

2. Acetazolamide Sustained Release Tablets or Capsules

• Strengths: 500 mg
• Format: Extended-release capsules or tablets for once-daily dosing
• Target Market: Patients requiring long-term intraocular pressure control or altitude sickness prevention

3. Acetazolamide Injectable (available on request)

• Strength: 500 mg/vial (lyophilized powder for IV use)
• Use: Emergency settings for intracranial hypertension and glaucoma
• Packaging: Glass vials with sterile water for injection
• Stability: Requires special storage and handling

Each product is developed with strict adherence to pharmacopeial standards (USP/BP/IP/EP), ensuring quality and therapeutic consistency.

Manufacturing Infrastructure

Our state-of-the-art manufacturing facilities are equipped to handle the production of complex small-molecule drugs like Acetazolamide. Key features of our infrastructure include:

• Separate production areas for oral solid dosage and sterile injectable forms
• High-speed tablet compression machines
• Blending, granulation, drying, and coating systems
• Strip and blister packaging lines with serialization support
• Cleanroom environments with Class 100,000 and 10,000 zones
• HVAC-controlled facilities for dust and humidity control
• Water systems (RO + WFI) meeting pharmacopeial purity requirements

Every batch of Acetazolamide manufactured at BluepillExpress undergoes a comprehensive set of quality checks to ensure compliance with international standards.

Quality Assurance & Control

Quality is the cornerstone of our operations. At BluepillExpress, we maintain a multi-level QA/QC system, involving rigorous testing protocols and compliance with current Good Manufacturing Practices (cGMP).

Our Quality Control measures include:

• Raw material verification and assay testing
• In-process controls at every manufacturing stage
• Finished product analysis (dissolution, disintegration, weight variation, etc.)
• Microbial contamination checks
• Stability testing under ICH guidelines (Zone I–IV)
• Impurity profiling and residual solvent testing
• Batch traceability with full documentation

Every batch is released with a Certificate of Analysis (CoA), Batch Manufacturing Record (BMR), and Material Safety Data Sheet (MSDS).

Custom Packaging Solutions

We offer a variety of customizable packaging options to cater to different markets, branding needs, and regulatory requirements.

Packaging Options Include:

• Blister packs (PVC, PVDC, Alu-Alu)
• Strip packs (aluminum foil)
• HDPE bottles (for large-scale institutional packaging)
• Individual sachets (where applicable)
• Child-resistant and senior-friendly closures
• QR codes, holographic seals, and serialization (track & trace)

All packaging is conducted in a controlled environment to ensure product stability and compliance with labeling and pharmacovigilance regulations.

Regulatory Support and Documentation

BluepillExpress provides comprehensive regulatory support for domestic and international product registrations. Our dedicated regulatory affairs team prepares all technical and legal documents to facilitate seamless market entry.

Documents and services offered include:

• WHO-GMP Certificate
• Certificate of Pharmaceutical Product (CoPP)
• Free Sale Certificate (FSC)
• Certificate of Origin (CoO)
• Site Master File
• Product Dossier in CTD / ACTD / eCTD formats
• Bioequivalence support data (where applicable)
• Stability studies (real-time and accelerated)

We also offer guidance on health authority submissions in countries including India, Nigeria, Kenya, Ghana, Vietnam, Philippines, Myanmar, Bolivia, and more.

Private Label and White Label Manufacturing

BluepillExpress empowers pharmaceutical entrepreneurs, retailers, and marketing agencies to launch their own brand of Acetazolamide through private label or white label manufacturing.

Our Private Label Services Include:

• Brand name registration and product design
• Custom artwork and packaging development
• Prototype samples for market testing
• NDA-based confidentiality agreements
• Quick turnaround time for first batch production
• Competitive pricing with scalable volume plans

We also stock white-label-ready formulations for clients looking for fast time-to-market under their own branding.

Export and Global Logistics

As a reputed pharmaceutical exporter, BluepillExpress ensures that our Acetazolamide formulations reach global clients on time and in optimal condition.

We manage:

• Freight forwarding (air and sea shipments)
• Incoterms: EXW, FOB, CIF, DDP as per client need
• Temperature-controlled supply chain (as needed)
• International customs clearance
• Supply chain tracking and batch visibility
• Export documentation and regulatory assistance

We have active export channels to more than 30 countries across Africa, Asia, the Middle East, CIS, and Latin America.

Minimum Order Quantities (MOQs)

We offer flexible MOQs designed to accommodate:

• Startups and brand launches
• Institutional and hospital procurement
• Government tenders and NGOs
• Large-scale B2B export orders

Custom MOQs are available based on packaging, formulation, and registration needs. We also provide pilot batches and small sample runs for stability and market evaluation purposes.

Client Testimonials

“We were able to launch our high-altitude sickness kit with Acetazolamide thanks to BluepillExpress’ fast documentation and reliable quality.”
— Travel Medicine Company, Nepal

“Excellent pricing, professional packaging, and transparent operations. Their Acetazolamide tablets were quickly approved by our local health authority.”
— Distributor, Middle East

“Their team was proactive in assisting us with dossier preparation and sample shipment. Product quality and delivery were exactly as promised.”
— Regulatory Manager, East Africa

Conclusion

Acetazolamide is a clinically essential drug with broad applications in ophthalmology, neurology, nephrology, and general medicine. Its effectiveness and versatility make it a high-demand molecule in both developed and developing healthcare markets.

At BluepillExpress, we combine pharmaceutical expertise, advanced infrastructure, and regulatory excellence to deliver Acetazolamide formulations that meet the highest standards of safety, quality, and efficacy. Whether you’re a startup seeking private label support or an established pharmaceutical company requiring bulk third-party production, we are your ideal partner.