Magnesium Hydroxide, Aluminium Hydroxide and Simethicone tablets

Digestive discomfort such as acidity, indigestion, heartburn, and gas is one of the most commonly reported health concerns globally, affecting people of all age groups and lifestyles. To provide rapid and sustained relief from such symptoms, combination formulations of Magnesium Hydroxide, Aluminium Hydroxide, and Simethicone are widely used. This time-tested triple-action formula provides a synergistic antacid and anti-flatulent effect, making it an essential component of over-the-counter (OTC) and prescription gastrointestinal therapy.

BluepillExpress, a WHO-GMP certified pharmaceutical manufacturer, is a trusted provider of third-party manufacturing solutions for this widely prescribed gastrointestinal formulation. Our advanced manufacturing capabilities, commitment to regulatory compliance, and ability to meet custom branding requirements make us a preferred manufacturing partner for pharmaceutical companies, OTC product marketers, hospital procurement units, and global export clients.

What is Magnesium Hydroxide, Aluminium Hydroxide & Simethicone?

This combination of antacids and anti-flatulent agents is used for the symptomatic treatment of acid indigestion, gastric discomfort, flatulence, and hyperacidity.

• Magnesium Hydroxide: A fast-acting antacid that neutralizes stomach acid and exerts a mild laxative effect, helping relieve constipation that may occur due to other antacids.
• Aluminium Hydroxide: A slower-acting antacid that neutralizes gastric acid and also binds phosphate in the gastrointestinal tract. It offers prolonged acid-neutralizing action and has a constipating effect, which is balanced by magnesium.
• Simethicone: A defoaming agent that reduces bloating and discomfort caused by gas. It works by reducing the surface tension of gas bubbles, allowing them to coalesce and be expelled more easily.

Together, these three ingredients create a well-balanced formulation that addresses multiple gastrointestinal symptoms with minimal side effects.

Therapeutic Class

• Antacid (Magnesium Hydroxide + Aluminium Hydroxide)
• Anti-Flatulent (Simethicone)
• Gastrointestinal Support

Key Benefits

1. Rapid Neutralization of Stomach Acid

Magnesium Hydroxide offers quick symptomatic relief by neutralizing excess hydrochloric acid in the stomach within minutes.

2. Sustained Relief from Heartburn and Indigestion

Aluminium Hydroxide acts more slowly and provides long-lasting relief, especially helpful in chronic gastritis and hyperacidity.

3. Relieves Gas and Bloating

Simethicone reduces surface tension of gas bubbles trapped in the stomach and intestines, making it easier for the body to expel them naturally.

4. Balanced Laxative and Constipating Effects

The opposing effects of magnesium and aluminium compounds create a neutral balance, avoiding unwanted constipation or diarrhea.

5. Well-Tolerated and Safe for Long-Term Use

Suitable for OTC and prescription use, this combination has a low side effect profile and is safe for most adults and elderly patients.

Indications

Magnesium Hydroxide + Aluminium Hydroxide + Simethicone tablets are indicated for the treatment and symptomatic relief of:

• Acid indigestion
• Gastric hyperacidity
• Heartburn and sour stomach
• Flatulence (gas)
• Functional dyspepsia
• Gastritis
• Bloating and abdominal discomfort

It may also be prescribed as adjunctive therapy in peptic ulcer disease or GERD (Gastroesophageal Reflux Disease), and for patients using NSAIDs, which can cause acid-related gastrointestinal discomfort.

Available Dosage and Strengths

BluepillExpress manufactures this triple-action gastrointestinal formulation in a variety of tablet strengths and formats:

Standard Formulation (Per Tablet):

• Magnesium Hydroxide – 250 mg
• Aluminium Hydroxide – 250 mg
• Simethicone – 50 mg

We can manufacture custom strength formulations based on client specifications and market needs.

Form Options:

• Chewable tablets (flavored, sugar-free available)
• Swallowable tablets with film coating
• Effervescent tablets (on request)
• Combination packs with antacids in liquid or powder form (on demand)

Our tablets are manufactured using pharma-grade raw materials, and all ingredients are compliant with USP, BP, or IP standards.

Dosage and Administration

General Adult Dosage:

• 1–2 tablets chewed or swallowed after meals and at bedtime, or as directed by a physician

Maximum Dose:

• Not more than 8 tablets in 24 hours unless advised

Pediatric Use:

• Not recommended without physician supervision

Note: Tablets should not be taken for more than 2 weeks continuously without medical evaluation, especially in cases of persistent symptoms.

Pharmacokinetics

• Onset of Action: Within 5–15 minutes
• Duration of Action: 1 to 3 hours depending on dosage and gastric contents
• Excretion: Primarily via feces (unabsorbed) and kidneys
• Absorption: Minimal systemic absorption unless taken in high doses

Simethicone is not absorbed and is excreted unchanged in feces.

Manufacturing Capabilities

At BluepillExpress, we have the infrastructure and expertise to produce large quantities of high-quality gastrointestinal formulations with assured consistency and safety.

Infrastructure Includes:

• High-speed tablet compression machines
• Dedicated lines for antacid and chewable formulations
• GMP-certified coating and granulation systems
• Tablet polishing and de-dusting equipment
• In-house analytical labs for real-time QC testing

We support private labeling, institutional supply, and bulk manufacturing models, serving clients across India and global markets.

Packaging and Labeling

Packaging is designed to ensure product stability, ease of use, and compliance with regulatory guidelines.

Primary Packaging Options:

• Alu-Alu or PVC blister strips
• HDPE bottles (30, 60, 100 tablets)
• Unit dose pouches (for hospitals or travel kits)

Secondary Packaging Options:

• Customized mono cartons with or without leaflets
• Multi-lingual labeling for export markets
• QR codes, barcodes, and serialization (if required)
• Shelf-ready retail packaging available

All packaging materials are moisture and light-resistant, ensuring product integrity throughout shelf life.

Quality and Compliance

Each batch of Magnesium Hydroxide + Aluminium Hydroxide + Simethicone tablets is produced under strict quality controls with full documentation and compliance to pharmacopeial standards.

Certifications:

• WHO-GMP
• ISO 22000:2018
• FSSAI License (if syrup versions are added)
• FDA India Manufacturing License

Quality Tests:

• Assay of active ingredients
• Disintegration and dissolution
• Uniformity of weight
• Microbial load testing
• Stability testing under ICH guidelines

Each batch is released with a Certificate of Analysis (CoA) and a Batch Manufacturing Record (BMR).

Regulatory and Documentation Support

BluepillExpress provides complete support for product registration and export compliance:

Available Documentation:

• Certificate of Pharmaceutical Product (COPP)
• Free Sale Certificate (FSC)
• Certificate of Origin (COO)
• CTD or ACTD-format Dossiers (Modules 1–5)
• MSDS (Material Safety Data Sheet)
• Manufacturing License and WHO-GMP certificate
• Label artwork files and promotional material (on request)

We assist with customized regulatory submissions for markets across Asia, Africa, Latin America, CIS, and the Middle East.

Export and Logistics Support

We provide end-to-end export and logistics services including:

• Sea, air, and land freight arrangements
• EXW, FOB, CIF, and DDP shipping terms
• Export documentation and customs coordination
• Batch-wise palletization and protective packing
• Dedicated support for NGO and government tenders

Our team ensures on-time delivery, global reach, and smooth order execution.

Minimum Order Quantities and Lead Times

Product Type	Minimum Order Quantity	Lead Time
Chewable/Swallowable Tablets	100,000 tablets	20–25 working days
Custom Formulations	50,000 tablets	25–30 working days
Sample / Pilot Batch	20–50 units	7–10 working days

MOQ may vary depending on packaging format, regulatory requirements, and custom labeling needs.

Market Demand and Applications

This triple-action tablet is a staple in:

• OTC pharmacy chains
• Generic product portfolios
• Hospital formularies and outpatient kits
• Travel medicine packages
• Public health tenders for GI treatment kits

Its affordability and broad efficacy make it suitable for both urban and rural healthcare systems, with strong demand across Asia, Africa, and Latin America.

Ideal Business Partners

We work with:

• OTC and generic pharmaceutical companies
• Institutional procurement teams
• Government and NGO tender suppliers
• Hospital and retail pharmacy chains
• Exporters seeking ready-to-register GI formulations
• E-commerce and telehealth platforms

We offer flexible solutions for branded generics, white-label supply, and international registrations.

Why Choose BluepillExpress?

• WHO-GMP certified facilities and global reach
• Competitive pricing for bulk volumes
• Full support from formulation to delivery
• End-to-end regulatory and export documentation
• Fast, reliable lead times and high product consistency
• Trusted by clients in over 30 countries

Conclusion

The combination of Magnesium Hydroxide, Aluminium Hydroxide, and Simethicone has stood the test of time as one of the most reliable, effective, and safe treatments for acidity, gas, and indigestion. Its broad applicability across age groups and its OTC availability make it an indispensable part of every pharmaceutical portfolio.

BluepillExpress is your ideal third-party manufacturing partner for this essential gastrointestinal formulation—delivering quality, scale, and global compliance, backed by decades of expertise.