Piroxicam

Piroxicam is a potent, long-acting non-steroidal anti-inflammatory drug (NSAID) used in the treatment of various inflammatory conditions, particularly osteoarthritis, rheumatoid arthritis, musculoskeletal pain, and post-operative inflammation. As a member of the oxicam class of NSAIDs, Piroxicam offers a unique advantage of once-daily dosing due to its long half-life, making it a popular choice in chronic pain and arthritis management.

At BluepillExpress, we specialize in the third-party manufacturing of Piroxicam formulations in various dosage forms, providing international clients with WHO-GMP certified, export-ready pharmaceuticals. With decades of expertise in anti-inflammatory product development and a robust global supply chain, BluepillExpress serves as a trusted partner for brands seeking high-quality, affordable, and compliant pharmaceutical solutions.

About BluepillExpress

BluepillExpress is a distinguished name in pharmaceutical third-party manufacturing and global exporting, providing complete formulation, production, packaging, and documentation support to healthcare companies worldwide. We operate with full compliance to WHO-GMP, ISO 9001:2015, and GLP certifications, manufacturing a wide range of pharmaceutical dosage forms including tablets, capsules, injectables, gels, and suspensions.

Our footprint spans across Africa, Asia, CIS, the Middle East, and Latin America, where we serve:

• Generic pharmaceutical companies
• Private-label healthcare brands
• Hospital procurement organizations
• Government health ministries and NGOs
• Distributors and contract marketing firms

We offer low MOQs for emerging brands and bulk manufacturing solutions for large-scale tenders and supply contracts.

Product Overview: Piroxicam

Piroxicam is a non-selective COX inhibitor that works by inhibiting the cyclooxygenase (COX) enzymes responsible for prostaglandin synthesis. This action helps reduce inflammation, pain, stiffness, and swelling associated with acute and chronic musculoskeletal and rheumatic conditions.

Piroxicam’s distinct pharmacokinetics—including a long plasma half-life of approximately 50 hours—allow for once-daily dosing, improving patient compliance in long-term therapy.

Mechanism of Action

Piroxicam exerts its effects by:

• Inhibiting COX-1 and COX-2 enzymes, thereby reducing prostaglandin synthesis.
• Decreasing inflammation, edema, and tissue degradation in inflammatory states.
• Reducing pain by blocking peripheral and central sensitization mechanisms.

This dual analgesic and anti-inflammatory effect makes it effective for arthritis, joint pain, soft tissue injuries, and post-surgical pain.

Therapeutic Indications

• Osteoarthritis
• Rheumatoid arthritis
• Ankylosing spondylitis
• Musculoskeletal disorders
• Postoperative and post-traumatic inflammation
• Tendinitis, bursitis, and backache
• Gout (acute episodes)
• Dental and orthopedic surgery pain

Piroxicam is also used off-label in some regions for dysmenorrhea and migraine-related pain, depending on regulatory approvals.

Available Dosage Forms and Strengths

BluepillExpress manufactures Piroxicam in several dosage forms to accommodate both oral and parenteral administration needs.

1. Oral Tablets / Capsules

• Piroxicam 10 mg
• Piroxicam 20 mg
• Film-coated for ease of swallowing
• Available in blister packs (10×10) or bottle packaging

2. Injectable Form (on request)

• Piroxicam 20 mg/mL in 1 mL ampoules
• For intramuscular use
• Used in acute pain episodes or post-operative settings

3. Topical Gel / Ointment (on request)

• Piroxicam 0.5% or 1% w/w
• Applied locally to relieve joint or muscle pain

All formulations adhere to IP, BP, USP, or Ph. Eur. specifications and are available in branded or generic presentations.

Manufacturing Infrastructure

Our cutting-edge pharmaceutical manufacturing facilities are equipped with automated, validated equipment for oral solid dosage forms and sterile injectables.

Key Infrastructure Capabilities:

• High-speed tablet compression and capsule filling lines
• Auto-coaters for film coating and stability enhancement
• Injectable ampoule filling and sealing lines (GMP Class 100 areas)
• Tube-filling lines for topical formulations
• Quality control labs equipped with HPLC, UV, IR, and microbiology setups
• Validated HVAC and water purification systems

Every manufacturing process follows stringent GMP protocols, with full traceability and batch integrity documentation.

Quality Assurance and Control

At BluepillExpress, quality is embedded at every level of our operation. Our Quality Management System (QMS) is compliant with ICH, GMP, and international pharmacopeial requirements.

Key Quality Control Procedures:

• Raw Material Testing: Identification, assay, and impurity profiling
• In-Process Testing: Granule uniformity, tablet hardness, dissolution
• Finished Product Testing: Assay, content uniformity, microbial limits, disintegration, pH (for gels)
• Stability Studies: As per ICH guidelines (real-time and accelerated)
• Sterility Testing for injectables
• Certificate of Analysis (CoA) and Batch Manufacturing Records (BMR) provided for every lot

All products are released only after complete analytical and microbiological clearance.

Packaging Solutions

We provide custom and standardized packaging options to ensure product stability, compliance, and brand recognition.

Packaging Options:

• Blister Packs: Alu-Alu or PVC-Alu (10×10, 10×15, 1×10)
• HDPE Bottles: For hospital and retail supply
• Ampoules: Packed in cartons with 5 or 10 units
• Tubes: Laminated or aluminum for topical gels

Multilingual printing and private label branding are available for country-specific requirements. All packaging is compliant with international guidelines on labeling, traceability, and tamper evidence.

Regulatory and Documentation Support

We provide complete regulatory assistance to help clients with product registrations, tenders, and market access.

Documentation Includes:

• WHO-GMP Certificate
• Certificate of Pharmaceutical Product (CoPP)
• Free Sale Certificate
• Certificate of Analysis (CoA)
• Stability Data (Zone II & IVB)
• Batch Manufacturing Records (BMR)
• CTD/ACTD Dossiers for product registration
• Product Artwork & Labeling Support
• Material Safety Data Sheet (MSDS)

Our dedicated regulatory team supports dossiers for submission in regions governed by NAFDAC, TGA, PPB, FDA, ANVISA, and others.

Global Export Services

BluepillExpress has a well-established global logistics network for fast, secure, and compliant export of pharmaceutical products.

Export Capabilities Include:

• Sea and air freight options
• Cold chain or ambient shipping (as required)
• Country-specific documentation
• Serialization, barcoding, and regulatory label support
• Export inspection and third-party verification services

We serve clients in:

• Africa: Nigeria, Kenya, Uganda, Ethiopia, South Africa
• Asia: Myanmar, Vietnam, Sri Lanka, Bangladesh
• CIS: Georgia, Uzbekistan, Kazakhstan
• Middle East: Iraq, UAE, Jordan, Yemen
• Latin America: Peru, Bolivia, Ecuador

We ensure compliance with all import and customs regulations, helping our clients navigate complex documentation and logistics with ease.

Ideal Clients and Use Cases

BluepillExpress supports the following client profiles:

• Generic medicine companies seeking branded or generic Piroxicam
• Hospitals and medical institutions needing bulk NSAID supply
• Government health departments procuring pain management drugs
• NGOs and international health missions
• Distributors and wholesalers across regulated and semi-regulated markets
• E-commerce platforms and OTC brands in the pain-relief category

We provide low MOQs for emerging businesses and bulk production for tenders and public supply programs.

Why Choose BluepillExpress?

1. WHO-GMP Certified Manufacturing
   Internationally accepted production standards
2. Complete Dossier Support
   CTD/ACTD files for seamless registration
3. Flexible Dosage and Packaging Options
   IR tablets, injectables, gels – tailored to your market
4. Global Export Logistics
   Documentation, customs clearance, and delivery
5. Consistent Quality and Compliance
   In-house labs and validated methods for every batch
6. Private Label and Branding Support
   Launch under your brand with full design assistance
7. Customer-Centric Approach
   Transparent pricing, reliable timelines, and dedicated support

Conclusion

As the demand for reliable, affordable anti-inflammatory agents grows globally, Piroxicam remains a cornerstone of pain management therapy, offering long-acting relief for millions of patients with chronic and acute inflammatory conditions.

With BluepillExpress as your third-party manufacturing partner, you gain a trusted ally committed to excellence in quality, compliance, and supply chain efficiency. Whether you are launching a new brand or fulfilling a government contract, we provide the infrastructure, documentation, and expertise to make your Piroxicam product a success.