ARIPIPRAZOLE

Aripiprazole is an atypical antipsychotic API widely used in the treatment of schizophrenia, bipolar disorder, major depressive disorder, and autism-related irritability.
It acts as a partial agonist at dopamine D2 and serotonin 5-HT1A receptors and an antagonist at 5-HT2A receptors, offering a unique pharmacological profile with fewer side effects than typical antipsychotics.

At Bluepill Express, Aripiprazole is manufactured under WHO-GMP and cGMP-certified facilities, ensuring superior purity, precise particle size distribution, and global regulatory compliance.

Therapeutic Category

Antipsychotic (Atypical)
Mood Stabilizer
Antidepressant Adjunct

Mechanism of Action

Aripiprazole works by modulating dopamine and serotonin activity in the brain.
It functions as a dopamine-serotonin system stabilizer, balancing neurotransmission to alleviate symptoms such as hallucinations, delusions, mood swings, and depression. This mechanism results in effective symptom control with minimal extrapyramidal side effects.

Chemical Information

Parameter	Details
Chemical Name	7-[4-[4-(2,3-Dichlorophenyl)-1-piperazinyl]butoxy]-3,4-dihydrocarbostyril
Molecular Formula	C23H27Cl2N3O2
Molecular Weight	448.38 g/mol
CAS Number	129722-12-9
Therapeutic Category	Antipsychotic
Pharmacopoeial Status	USP / EP / IP Compliant

Physical & Chemical Properties

Property	Specification
Appearance	White to off-white crystalline powder
Solubility	Insoluble in water, freely soluble in chloroform and methanol
Melting Point	139°C – 144°C
Optical Rotation	Neutral
Storage	Store below 25°C, in a dry and dark place
Odor	Odorless

Technical Specifications (Typical Bluepill Express Standard)

Parameter	Specification
Identification	Positive by IR/UV
Assay (Purity)	≥ 99.0% (HPLC)
Related Substances	≤ 0.3% individual impurity
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Particle Size	D90 < 50 µm (Micronized grade available)
pH (1% solution)	6.0 – 7.5

Pharmacological Applications

Schizophrenia: Reduces positive and negative symptoms with lower sedation and metabolic side effects.
Bipolar Disorder: Stabilizes mood swings and prevents manic or depressive episodes.
Major Depressive Disorder (Adjunct): Enhances antidepressant efficacy when used with SSRIs or SNRIs.
Autism Spectrum Disorder: Helps control irritability, aggression, and repetitive behavior.

Packaging & Export Details

Detail	Description
Available Packs	1 kg / 5 kg / 10 kg / 25 kg HDPE or Fiber Drums with double poly liner
Labeling	Product name, batch number, MFG/EXP date, storage conditions
Shelf Life	3–5 years (under controlled conditions)
Export Markets	Africa, Middle East, CIS, South America, and Asia Pacific