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Metoclopramide Hydrochloride is a dopamine D2 receptor antagonist widely used as an antiemetic and prokinetic agent in the treatment of nausea, vomiting, gastroesophageal reflux disease (GERD), and gastroparesis. It enhances gastric emptying and increases the tone of the lower esophageal sphincter, thereby preventing acid reflux and improving digestive motility.
At Bluepill Express, we manufacture and export pharmaceutical-grade Metoclopramide Hydrochloride API that complies with IP, BP, USP, and EP pharmacopeial standards. Our product is produced under WHO-GMP, ISO 9001:2015, and cGMP-certified facilities, ensuring purity, potency, and consistent particle size distribution for optimal formulation performance in tablets, injections, and oral solutions.
Bluepill Express is recognized for its high-quality APIs and strict adherence to international regulatory and documentation standards, making it a trusted name among global pharmaceutical manufacturers.
Pharmacological Information:
- Therapeutic Class: Antiemetic / Gastroprokinetic
- Pharmacological Category: Dopamine (D2) Receptor Antagonist
- CAS Number: 364-62-5
- Molecular Formula: C14H22ClN3O2
- Molecular Weight: 299.80 g/mol
- Appearance: White to off-white crystalline powder
- Solubility: Freely soluble in water, slightly soluble in alcohol
- Melting Point: 183°C – 186°C
- Storage: Store in a tightly closed container, below 25°C, in a cool, dry, dark place
Mode of Action:
Metoclopramide Hydrochloride works by blocking dopamine D2 receptors in the chemoreceptor trigger zone (CTZ) of the central nervous system and the gastrointestinal tract. This inhibits the vomiting reflex and stimulates gastric motility without increasing gastric secretions. Additionally, it enhances acetylcholine release, improving intestinal movement and coordination.
Applications and Uses:
- Treatment of Nausea & Vomiting (including postoperative, migraine, and chemotherapy-induced)
- Gastroesophageal Reflux Disease (GERD) – Improves lower esophageal sphincter tone
- Diabetic Gastroparesis – Enhances gastric emptying in diabetic patients
- Adjunct in Migraine Therapy – Improves absorption of oral analgesics
- Diagnostic Procedures – Promotes gastric emptying before radiologic exams
Technical Specifications:
- Assay (Purity): ≥ 99.5%
- Identification: IR spectrum matches reference standard
- Loss on Drying: ≤ 0.5%
- Residue on Ignition: ≤ 0.1%
- Heavy Metals: ≤ 10 ppm
- Specific Optical Rotation: +20° to +25°
- Related Substances: ≤ 0.1% (individual impurity)
- Microbial Limits: Complies with pharmacopeial specifications
Manufacturing & Quality Assurance – Bluepill Express:
- Produced under WHO-GMP and ISO-certified facilities
- Micronized powder ensures uniformity and dissolution
- COA, MSDS, and TDS provided with each batch
- Pharmacopeial compliance: IP / BP / USP / EP
- HPLC-tested for purity and stability
- Suitable for tablet, injection, and oral solution formulations
Packaging & Export Details:
- Available Packs: 1 kg, 5 kg, 10 kg, 25 kg HDPE drums with inner liner
- Shelf Life: 36 months from manufacturing date
- Labeling: As per export and pharmacopeial standards
- Export Markets: Africa, Europe, Asia, Middle East, and Latin America
- Documentation Provided:
- Certificate of Analysis (COA)
- Material Safety Data Sheet (MSDS)
- Technical Data Sheet (TDS)
- Non-GMO & Allergen-Free Declaration
- Stability & Residual Solvent Data (on request)
