Hydrochlorothiazide API is a thiazide diuretic active pharmaceutical ingredient widely used in the formulation of medications that manage hypertension (high blood pressure) and edema (fluid retention) associated with heart failure, kidney disorders, and liver cirrhosis. It works by increasing the excretion of sodium and water through the kidneys, effectively reducing blood volume and controlling blood pressure.
Hydrochlorothiazide (HCTZ) is one of the most trusted and time-tested diuretic agents used globally, both as a standalone medication and in combination therapy with antihypertensive drugs such as Losartan, Lisinopril, and Valsartan. Its reliable pharmacological profile, excellent safety record, and proven therapeutic benefits make it an essential API in cardiovascular and renal care formulations.
At Bluepill Express, Hydrochlorothiazide API is manufactured under WHO-GMP, ISO, and cGMP certified facilities, ensuring superior quality, high purity, and consistent assay performance. Every batch is validated using HPLC, IR spectroscopy, and impurity profiling to meet USP / BP / IP pharmacopoeial specifications.
Therapeutic Applications:
- Management of essential hypertension (high blood pressure)
- Treatment of edema due to heart failure, kidney, or liver diseases
- Reduces risk of stroke, heart attack, and kidney complications
- Used in fixed-dose combination therapies for blood pressure control
- Enhances sodium and chloride excretion to maintain electrolyte balance
Technical Specifications:
- Chemical Name: Hydrochlorothiazide
- Molecular Formula: C₇H₈ClN₃O₄S₂
- Molecular Weight: 297.74 g/mol
- CAS Number: 58-93-5
- Appearance: White or almost white crystalline powder
- Solubility: Slightly soluble in water; freely soluble in sodium hydroxide solution
- Assay (on dried basis): NLT 99.0%
- Storage Conditions: Store in a cool, dry place below 30°C, protected from light and moisture.
Pharmacological Action:
Hydrochlorothiazide acts on the distal convoluted tubules of the kidneys, inhibiting the Na⁺/Cl⁻ co-transporter, leading to increased excretion of sodium, chloride, and water. This diuretic action lowers plasma volume, reduces cardiac output, and stabilizes blood pressure. The drug also enhances calcium reabsorption, making it useful in certain cases of calcium nephrolithiasis (kidney stones).
Manufacturing & Quality Assurance (by Bluepill Express):
- Produced in WHO-GMP and ISO-certified manufacturing facilities
- Supported with COA, MSDS, and DMF documentation for international registrations
- Complies with USP / BP / IP pharmacopoeial standards
- Ensures high assay value, low impurity profile, and long-term stability
- Supplied to regulated and semi-regulated markets worldwide
