Cinnarizine

Cinnarizine is a well-known antihistamine and calcium channel blocker commonly used for the treatment of vertigo, motion sickness, and vestibular disorders. It also finds applications in addressing cerebral circulatory disturbances and vascular-related conditions, making it a versatile medication in neurology and ENT practice. With its proven efficacy in managing dizziness, nausea, and balance disorders, Cinnarizine remains an essential medication in global healthcare systems.

BluepillExpress is proud to offer comprehensive third-party manufacturing services for Cinnarizine, meeting the rising global demand with WHO-GMP certified production, flexible dosage forms, and complete regulatory support. Our capabilities make us a reliable partner for private label brands, government supply programs, and institutional buyers around the world.

About BluepillExpress

BluepillExpress is a globally reputed pharmaceutical manufacturer and exporter, offering third-party manufacturing solutions to over 25 countries across Asia, Africa, CIS, Latin America, and the Middle East. With manufacturing facilities certified by WHO-GMP, ISO 9001:2015, and GLP, we specialize in the large-scale production of generic formulations backed by scientific excellence and regulatory compliance.

Our services include:

• Custom formulation and dosage design
• Private label manufacturing and bulk supply
• Regulatory documentation and CTD dossier support
• Packaging and branding as per country-specific guidelines
• Seamless export logistics and after-sales support

We offer end-to-end solutions for clients looking to expand their product line with reliable and quality-assured Cinnarizine formulations.

Product Overview: Cinnarizine

Cinnarizine is a piperazine derivative with potent antihistaminic and vasodilatory effects. It is widely used in the management of motion sickness, nausea, vomiting, tinnitus, Meniere’s disease, and other conditions associated with the inner ear and balance system.

Key Therapeutic Indications:

• Vertigo and balance disorders
• Motion sickness (prophylaxis and treatment)
• Meniere’s disease and tinnitus
• Nausea and vomiting of vestibular origin
• Cerebrovascular insufficiency
• Peripheral circulatory disorders (off-label)

Due to its central action on the vestibular system, Cinnarizine is especially beneficial for elderly patients prone to balance issues, as well as travelers and individuals susceptible to motion-induced nausea.

Mechanism of Action

Cinnarizine works by:

• Blocking histamine H1 receptors in the vestibular nuclei of the brain
• Inhibiting calcium influx into vascular smooth muscle, leading to vasodilation
• Reducing vestibular stimulation and dampening labyrinthine excitability
• Improving microcirculation in the inner ear and brain

This combined antihistaminic and vasodilatory action makes Cinnarizine effective in treating both neurological and vascular symptoms associated with vertigo and dizziness.

Available Dosage Forms

BluepillExpress manufactures Cinnarizine in a variety of standard dosage forms suitable for adult and geriatric use, compliant with IP, BP, USP, and Ph. Eur. standards.

1. Cinnarizine Tablets

• 25 mg
• 75 mg (for once-daily extended relief or fixed-dose combinations)
• Film-coated for easy swallowing
• Blister, strip, or bulk pack options available

2. Cinnarizine Chewable Tablets (on request)

• Flavored variants (orange, mint, lemon) for motion sickness
• Ideal for pediatric and travel-related use

3. Fixed-Dose Combinations (on client request)

• Cinnarizine + Dimenhydrinate (for enhanced anti-vertigo effect)
• Cinnarizine + Piracetam (for cognitive and vascular synergy)
• Cinnarizine + Domperidone (for nausea control)

All formulations are developed using pharmaceutical-grade APIs, with stability and performance tested under real and accelerated conditions.

Packaging Options

We provide export-compliant, customizable packaging that aligns with your branding, regulatory requirements, and market preferences.

Tablet Packaging:

• Blister packs (PVC/Alu, Alu-Alu)
• Strip packs (paper, foil, or poly)
• Outer cartons with multilingual labeling
• Bulk packs for institutional or hospital supply

Custom Branding Support:

• Logo printing and box design
• Regulatory text integration (warnings, usage, storage)
• Country-specific barcoding and serialization (where required)

Packaging is tested for moisture protection, seal integrity, and light resistance to maintain product stability and shelf-life during transport and storage.

Manufacturing Infrastructure

Our manufacturing facilities are fully equipped to produce solid oral formulations, adhering to stringent GMP protocols and environmental controls. Highlights include:

• Granulation, compression, and film-coating equipment
• HVAC-controlled cleanrooms (ISO class)
• In-house water purification and waste management systems
• High-speed blister/strip packing lines
• Automatic tablet inspection and metal detection
• Validated SOPs and batch tracking systems

All operations are digitally tracked through electronic batch manufacturing records (eBMRs), ensuring transparency and traceability.

Quality Control and Assurance

At BluepillExpress, quality assurance is built into every step of the manufacturing process. Our fully equipped laboratories and experienced QA/QC team ensure that Cinnarizine formulations meet global quality benchmarks.

Our Quality Systems Include:

• Raw material analysis (identity, purity, microbial load)
• In-process quality checks (weight variation, hardness, friability, disintegration)
• Final product testing:
  • Assay of active ingredients
  • Dissolution and uniformity
  • Stability (accelerated and long-term)
  • Packaging and labeling verification
  • Microbial testing

All quality protocols are in compliance with ICH Q10, ISO 9001:2015, and Good Laboratory Practices (GLP). Batch-wise Certificate of Analysis (CoA) and Certificate of Compliance (CoC) are provided with every consignment.

Regulatory Documentation and Support

We offer complete regulatory support and documentation packages to ensure smooth market entry and product registration.

Our standard documentation includes:

• Certificate of Pharmaceutical Product (CoPP)
• Certificate of Analysis (CoA)
• Free Sale Certificate
• WHO-GMP certificate
• Stability data and shelf-life report
• Master Formula Record and Batch Manufacturing Record
• CTD or ACTD dossiers for global registration
• Material Safety Data Sheet (MSDS)

Our regulatory team also provides guidance for country-specific registrations, including support for tenders, private brand approvals, and public health programs.

Export and Global Logistics

BluepillExpress has a strong global export network and offers door-to-port and door-to-door delivery services for all Cinnarizine formulations.

Our export services include:

• Multilingual artwork and carton printing
• Air and sea freight with full documentation
• Customs clearance and handling at destination
• Serialization and tamper-evidence for traceability
• Cold chain solutions (if required for related drugs)

We have successfully delivered pharmaceutical products to clients in:

• Africa: Nigeria, Kenya, Uganda, Ghana, South Africa
• Middle East: Iraq, UAE, Jordan, Yemen
• CIS: Uzbekistan, Kazakhstan, Tajikistan
• Asia: Bangladesh, Myanmar, Sri Lanka, Philippines
• Latin America: Peru, Bolivia, Dominican Republic

Target Clients and Applications

Our Cinnarizine third-party manufacturing services cater to:

• Generic pharmaceutical companies
• OTC and travel health product marketers
• Hospital and institutional suppliers
• NGOs and health agencies in vertigo treatment programs
• Retail pharmacy chains and online supplement sellers
• Exporters focused on neurology and ENT formulations

We also assist startup brands and new market entrants with low minimum order quantities (MOQs) and flexible branding support.

Why Choose BluepillExpress?

1. WHO-GMP Certified Facilities
   Trusted globally for excellence in pharmaceutical manufacturing.
2. Comprehensive Product Portfolio
   Cinnarizine in multiple strengths and combinations to suit market needs.
3. Custom Branding and Low MOQs
   Helping you grow your brand with small batches and customized packaging.
4. Complete Regulatory Support
   CTD dossiers, CoPPs, and assistance with registration in any country.
5. Global Export Capability
   Proven logistics and documentation for over 25 countries.
6. Batch-to-Batch Consistency and Quality Assurance
   Validated processes and full transparency from start to finish.

Conclusion

Cinnarizine is an effective and trusted treatment for vertigo, nausea, and motion-related disorders. Its long-standing safety record and widespread clinical use make it a mainstay in ENT, neurology, and travel medicine segments worldwide.

At BluepillExpress, we combine scientific expertise with regulatory know-how and global supply experience to deliver world-class third-party manufacturing services. Whether you are an established brand or an emerging distributor, we are ready to help you launch and scale your Cinnarizine products with confidence.