Neomycin, bacitracin & sulphacetamide

Neomycin, Bacitracin, and Sulphacetamide are three potent antibacterial agents that are often combined in topical or ophthalmic formulations to provide broad-spectrum antimicrobial coverage. These triple-combination therapies are extensively used to treat skin infections, eye infections, wounds, and post-operative inflammation caused by a wide range of gram-positive and gram-negative bacteria.

At BluepillExpress, we specialize in the third-party manufacturing of this highly effective triple antibiotic combination, offering global clients WHO-GMP-certified production, precise formulation, and complete regulatory documentation for various dosage forms. Whether for dermatological use or ophthalmic application, we are equipped to deliver scalable solutions tailored to diverse market requirements.

About BluepillExpress

BluepillExpress is a globally recognized name in the field of pharmaceutical contract manufacturing and exports. With certified manufacturing units and a reputation for timely delivery, quality assurance, and regulatory compliance, we support pharmaceutical brands, government agencies, and health institutions in over 25 countries, including regions in Africa, Asia, CIS, Latin America, and the Middle East.

Our services include:

• Contract and third-party manufacturing
• Formulation development and customization
• Regulatory filing and documentation support
• Flexible packaging and private label solutions
• Export logistics and distribution support

We adhere to international quality standards, including WHO-GMP, ISO 9001:2015, and GLP, offering high-quality pharmaceutical products across therapeutic segments.

Product Overview: Neomycin, Bacitracin & Sulphacetamide Combination

This triple antibiotic formulation is a synergistic combination of three powerful antimicrobials:

• Neomycin: An aminoglycoside antibiotic that inhibits protein synthesis in bacteria, effective against a wide range of gram-negative organisms.
• Bacitracin: A peptide antibiotic active mainly against gram-positive bacteria, particularly Staphylococcus aureus and Streptococcus pyogenes.
• Sulphacetamide (Sulfacetamide): A sulfonamide antibiotic that inhibits folic acid synthesis, providing additional coverage against Haemophilus influenzae, E. coli, and other susceptible organisms.

The combination is frequently prescribed in dermatology and ophthalmology to treat bacterial conjunctivitis, blepharitis, infected wounds, minor burns, abrasions, and surgical wounds.

Mechanism of Action

Each active ingredient in the combination plays a unique role in disrupting bacterial viability:

• Neomycin binds to the 30S subunit of bacterial ribosomes, halting protein synthesis.
• Bacitracin inhibits bacterial cell wall synthesis, primarily affecting gram-positive organisms.
• Sulphacetamide blocks the conversion of PABA to dihydrofolic acid, hindering folate metabolism essential for bacterial growth.

The combined effect creates a broad-spectrum antimicrobial shield, minimizing resistance development and enhancing therapeutic outcomes.

Therapeutic Indications

Dermatological Uses:

• Infected wounds and cuts
• Minor burns
• Impetigo and folliculitis
• Post-surgical wound care
• Skin ulcers and abrasions

Ophthalmic Uses (when formulated for eye application):

• Bacterial conjunctivitis
• Blepharitis and blepharoconjunctivitis
• Post-operative prophylaxis (e.g., cataract surgery)
• External ocular infections

Ear Formulations (if applicable):

• Bacterial otitis externa (ear drops or ointment)

Available Dosage Forms

At BluepillExpress, we offer a variety of dosage forms for the Neomycin, Bacitracin, and Sulphacetamide combination. Each product is manufactured with adherence to USP, BP, IP, and Ph. Eur. standards.

1. Topical Ointment

• Neomycin (5 mg/g) + Bacitracin (500 IU/g) + Sulphacetamide (100 mg/g)
• Available in 5 g, 10 g, 15 g, and 30 g aluminum tubes
• Applied to skin infections or minor wounds

2. Ophthalmic Ointment

• Sterile formulation for external ocular use
• Neomycin Sulphate + Bacitracin Zinc + Sulfacetamide Sodium
• Packaged in 3.5 g ophthalmic tubes
• Designed for ease of application with nozzle tip

3. Ophthalmic Solution or Drops (on request)

• Water-based, sterile eye drops
• Buffered pH to match ocular fluid
• Preserved with benzalkonium chloride or preservative-free (if required)

All formulations are developed with low-irritant bases, ensuring patient comfort and high therapeutic efficacy.

Manufacturing Infrastructure

BluepillExpress operates world-class manufacturing facilities that conform to Good Manufacturing Practices (GMP). Our infrastructure includes:

• Dedicated production lines for ointments and sterile ophthalmics
• Tube filling and crimping lines for semi-solids
• Class 100 sterile zones for ophthalmic manufacturing
• HEPA-filtered air handling systems
• Validated purified water systems for injection-grade requirements
• Automated labeling, packing, and serialization systems

Our facilities support both bulk production and custom batches, meeting the varying demands of hospital supply chains, retail pharmaceutical markets, and public health procurements.

Quality Assurance and Control

We maintain a stringent Quality Management System (QMS) that ensures consistent product quality and regulatory compliance.

Our QA/QC Capabilities Include:

• Raw material identification and assay
• In-process checks: uniformity, viscosity, pH, particulate matter
• Sterility testing for ophthalmic and topical formulations
• Microbial limit testing
• Finished product testing for potency and shelf-life
• Real-time and accelerated stability studies as per ICH guidelines

Every batch is accompanied by a Certificate of Analysis (CoA) and meets the defined specifications for content uniformity, purity, and microbial safety.

Packaging and Private Labeling

We offer customized packaging services to align with client branding, market regulations, and end-user preferences.

Packaging Formats Include:

• Aluminum collapsible tubes (for ointments)
• LDPE/HDPE ophthalmic tubes with dropper tips
• Sterile blister or pouch packing
• Multilingual labeling for global distribution
• Outer cartons with package inserts

Our design team supports custom artwork, logo integration, and product naming, ensuring that your product stands out on the shelf while meeting regulatory compliance.

Regulatory Documentation Support

BluepillExpress provides a comprehensive set of documents required for product registration and regulatory approvals in international markets:

• WHO-GMP Certificate
• Certificate of Pharmaceutical Product (CoPP)
• Free Sale Certificate
• Certificate of Analysis (CoA)
• Batch Manufacturing Records (BMR)
• Product Master Files and stability data
• Common Technical Documents (CTD/eCTD)
• Material Safety Data Sheets (MSDS)

We provide support for compliance with NAFDAC, FDA, TGA, ANVISA, PPB, and other regional regulatory authorities.

Global Export and Logistics Support

Our extensive export network ensures smooth product delivery to various global regions with full compliance and documentation.

Logistics and Export Services Include:

• Country-specific labeling and barcoding
• Assistance with import permits and registration
• Freight forwarding via air and sea
• Cold chain supply (if required for ophthalmics)
• Pre-shipment inspection and third-party certifications
• Timely dispatch and real-time shipment tracking

We are active in pharmaceutical exports to:

• Africa: Ghana, Nigeria, Kenya, Ethiopia, South Africa
• Asia: Sri Lanka, Bangladesh, Vietnam, Myanmar
• CIS: Uzbekistan, Georgia, Tajikistan
• Middle East: UAE, Iraq, Saudi Arabia
• Latin America: Peru, Bolivia, Guatemala

Ideal Clients and Applications

Our third-party manufacturing services are tailored for:

• Generic pharmaceutical companies
• Ophthalmic and dermatology product distributors
• Government healthcare procurement agencies
• NGOs and health missions
• E-commerce and telehealth platforms
• Private-label cosmetic and first-aid brands

We cater to clients of all sizes — from startups seeking small batches to large companies requiring bulk production.

Why Choose BluepillExpress?

1. WHO-GMP Certified Manufacturing
   Our facilities meet the highest global standards for quality and hygiene.
2. End-to-End Manufacturing and Export Solutions
   From raw material sourcing to finished product delivery, we manage it all.
3. Wide Range of Dosage Forms
   Ointments, ophthalmic drops, sterile creams – all under one roof.
4. Custom Formulations and Branding
   We help you launch your product under your own brand name.
5. Global Documentation Expertise
   Our regulatory team supports seamless product registration across markets.
6. Reliable Supply Chain and Competitive Pricing
   We ensure consistent product availability with transparent pricing.
7. Dedicated Support Team
   Our technical, regulatory, and commercial teams are always ready to assist.

Conclusion

The combination of Neomycin, Bacitracin, and Sulphacetamide is a powerful, broad-spectrum treatment for bacterial infections affecting the skin and eyes. Its effectiveness, safety, and wide range of applications make it a valuable addition to any pharmaceutical portfolio.

With BluepillExpress as your third-party manufacturing partner, you gain access to high-quality production, global regulatory expertise, private-label flexibility, and a proven export infrastructure. Our commitment to excellence ensures that your brand reaches healthcare providers and patients with the trust it deserves.