Cyproheptadine Hydrochloride

Cyproheptadine Hydrochloride is a first-generation antihistamine with antiserotonergic, anticholinergic, and appetite-stimulating properties. It is used widely in the treatment of allergic reactions, seasonal rhinitis, urticaria, and also as an appetite stimulant in underweight individuals or patients with poor appetite due to chronic illness.

At BluepillExpress, we offer comprehensive third-party manufacturing services for Cyproheptadine Hydrochloride across various dosage forms and strengths. As a WHO-GMP certified and ISO 9001:2015 accredited pharmaceutical manufacturer, we uphold the highest standards of quality, safety, and compliance, providing scalable, timely, and customized production for pharmaceutical companies, hospitals, and distributors worldwide.

Product Profile: Cyproheptadine Hydrochloride

Cyproheptadine Hydrochloride is a histamine H1 receptor antagonist and also a serotonin antagonist. It helps alleviate symptoms of allergy and also stimulates appetite by antagonizing serotonin receptors in the hypothalamus.

Pharmacological Properties:

• Antihistaminic: Relieves symptoms of allergic rhinitis, hay fever, and urticaria
• Antiserotonergic: Useful in conditions like serotonin syndrome and vascular headaches
• Appetite stimulant: Commonly used in cachexia, anorexia nervosa, and malnutrition
• Sedative effect: Beneficial in nighttime allergic conditions

Therapeutic Applications

Our third-party manufactured Cyproheptadine Hydrochloride formulations are designed to meet the needs of both allergic disorders and nutritional support therapy.

Indications:

• Allergic rhinitis (seasonal and perennial)
• Vasomotor rhinitis
• Allergic conjunctivitis
• Chronic urticaria
• Cold-induced urticaria
• Dermatographism
• Appetite stimulation in adults and children
• Migraines and cluster headaches (off-label use)
• Cushing’s syndrome (supportive use)
• Serotonin syndrome (off-label)

We cater to a variety of healthcare sectors, including general practice, pediatrics, internal medicine, and nutrition therapy.

Why Partner with BluepillExpress for Cyproheptadine Hydrochloride Manufacturing?

BluepillExpress is a global leader in custom pharmaceutical manufacturing, offering full-service support from product development to final export. With a client-centric approach, we provide:

• WHO-GMP certified manufacturing with cGMP protocols
• Customizable strengths, dosage forms, and packaging
• High-quality raw material sourcing and validation
• Dedicated support for brand owners and institutional buyers
• End-to-end regulatory and dossier preparation services
• International market registration assistance
• Competitive pricing and flexible batch sizes

Our capacity allows us to serve pharmaceutical marketing companies, hospitals, government tenders, and overseas distributors with precision and reliability.

Available Formulations

We manufacture Cyproheptadine Hydrochloride in various forms tailored to market demand, including pediatric-friendly and export-ready formats.

1. Cyproheptadine Hydrochloride Tablets 4 mg

• Indication: Allergic reactions, appetite stimulation
• Dosage Form: Oral tablet
• Packaging: 10×10 strip/blister packs
• Shelf Life: 24–36 months
• Color: Custom color approved by regulatory guidelines

2. Cyproheptadine Hydrochloride Syrup (2 mg/5 ml)

• Target Group: Pediatric use and appetite stimulation
• Flavor: Fruity flavors like orange, pineapple, strawberry (customizable)
• Bottle Sizes: 100 ml, 150 ml, 200 ml
• Inclusions: Measuring cap, patient leaflet
• Packaging: Amber PET/HDPE bottles with cartons

3. Cyproheptadine HCl Oral Drops (For infants)

• Concentration: 0.4 mg/ml (customizable)
• Packaging: 15 ml dropper bottles
• Preservative-free option available
• Intended Use: Infant appetite stimulation

4. Cyproheptadine Combinations (on request)

• Cyproheptadine + Multivitamins
• Cyproheptadine + Tricholine Citrate (for liver and appetite support)
• Custom FDCs based on regulatory clearance

All formulations conform to IP/BP/USP/EP pharmacopeial standards and are available for domestic and international distribution.

Manufacturing Infrastructure

Our production plant integrates advanced pharmaceutical technology and validated protocols to ensure consistent quality and safety.

Facility Highlights:

• WHO-GMP compliant facility with cleanroom infrastructure
• Dedicated areas for liquid and solid oral formulations
• SS316L contact parts to prevent contamination
• Automated granulation, blending, and tablet compression
• Liquid syrup section with emulsification and homogenization systems
• Automatic filling, labeling, and packaging lines
• HVAC and HEPA filtration to maintain sterility and temperature control

All processes are documented with Standard Operating Procedures (SOPs) and monitored for continuous improvement.

Quality Control and Quality Assurance

BluepillExpress adheres to stringent QA/QC procedures across all stages of production. We use analytical instruments and microbiological labs for thorough batch testing.

Quality Testing Parameters:

• Active ingredient assay and content uniformity
• pH and specific gravity (for syrup formulations)
• Viscosity, flavor stability, and color retention
• Dissolution and disintegration for tablets
• Microbial load and preservative efficacy
• Stability studies (accelerated and long-term as per ICH)
• Packaging integrity and leak testing

Documentation Provided:

• Certificate of Analysis (COA)
• Certificate of Origin (COO)
• Batch Manufacturing Record (BMR)
• Material Safety Data Sheet (MSDS)
• Method of Analysis (MOA)
• Stability data and shelf-life declaration
• Product specification sheet

Regulatory Support and Dossier Services

BluepillExpress offers a full range of regulatory assistance for registering Cyproheptadine Hydrochloride in your target market.

Our Services Include:

• CTD/eCTD/ACTD dossier preparation
• WHO-GMP Certificate
• Free Sale Certificate (FSC)
• Certificate of Pharmaceutical Product (CoPP)
• Site Master File (SMF)
• Toxicology and Stability reports
• Product samples and packaging mockups
• Audit and regulatory inspection readiness

We have successfully assisted clients in registering Cyproheptadine across Africa, CIS, Southeast Asia, LATAM, and Middle Eastern territories.

Packaging and Branding Options

Proper packaging ensures product stability, compliance, and consumer appeal. We offer customizable packaging to align with your branding and regulatory needs.

Packaging Types:

• Blister packs (PVC/Alu or Alu-Alu)
• Strip packs with foil coating
• PET and HDPE bottles with pilfer-proof caps
• Outer cartons with artwork in multiple languages
• Serialization and barcoding for traceability
• Tamper-evident seals and shrink-wrap packaging

Our in-house design team provides labeling and branding services, helping private label clients stand out in the market.

Private Label and White Label Solutions

BluepillExpress is a preferred manufacturing partner for companies looking to launch their own brand in the allergy and appetite management category.

Services Include:

• Custom brand name and packaging
• Market-specific labeling in multiple languages
• Regulatory-compliant design
• Fast-track production with low MOQ
• NDA protection and brand confidentiality
• Sample packs and promotional literature (optional)

Whether you’re a new market entrant or a large distributor, we’ll support your private label journey from idea to execution.

Export Capabilities

BluepillExpress is a global exporter of Cyproheptadine Hydrochloride to over 30 countries across Africa, Asia, CIS, and the Middle East. We are experienced in meeting both public procurement and retail market needs.

Export Services Include:

• Air and sea freight with EXW, FOB, CIF, DDP terms
• Product registration support in importing countries
• Temperature-controlled shipping (on request)
• Tender documentation and NGO supply chain coordination
• Import clearance assistance and freight forwarding
• Regulatory updates and ongoing market support

We specialize in multi-market compliance, supporting clients in regulatory filings, product launches, and recurring supply contracts.

Minimum Order Quantities (MOQ)

We understand that different clients have different scale requirements. That’s why we offer flexible MOQs, such as:

• Small trial batches for product testing or registration
• Mid-size orders for hospital supply or distribution
• Bulk production for national tenders or retail chains
• Repeat contracts with periodic dispatch options

MOQ depends on dosage form, customization level, and regulatory requirements.

Client Testimonials

“BluepillExpress helped us launch our pediatric appetite syrup in record time. Excellent product quality and reliable service.”
— Pediatric Pharma Company, East Africa

“We’ve sourced Cyproheptadine tablets from BluepillExpress for three consecutive tenders. Product quality, documentation, and logistics were impeccable.”
— Government Supplier, Southeast Asia

“Their private label team created a complete solution for our pharmacy chain. We’re now the leading Cyproheptadine brand in our region.”
— Pharma Retail Brand, Middle East

Conclusion

Cyproheptadine Hydrochloride is a clinically versatile molecule with applications in both therapeutic allergy management and nutritional support. Its global demand is steady and rising, particularly in developing markets, pediatric care, and dietary support programs.

At BluepillExpress, we deliver more than just a product—we deliver a trusted partnership with quality, compliance, and reliability. Whether you need Cyproheptadine tablets, syrups, oral drops, or customized FDCs, we are equipped to manufacture, brand, and ship your products worldwide.